ID A0A384BUF1_URSMA Unreviewed; 82 AA.
AC A0A384BUF1;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Heat shock factor-binding protein 1 {ECO:0000256|ARBA:ARBA00039223};
GN Name=LOC103659967 {ECO:0000313|RefSeq:XP_008685785.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008685785.1};
RN [1] {ECO:0000313|RefSeq:XP_008685785.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008685785.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Negative regulator of the heat shock response. Negatively
CC affects HSF1 DNA-binding activity. May have a role in the suppression
CC of the activation of the stress response during the aging process.
CC {ECO:0000256|ARBA:ARBA00037689}.
CC -!- SUBUNIT: Homohexamer. Associates with heptad repeats of HSF1 trimers
CC and probably also HSF1 monomers, and with HSP70. Association with HSF1
CC trimers and HSP70 coincides with attenuation of heat shock response and
CC the conversion of HSF1 trimer to monomer.
CC {ECO:0000256|ARBA:ARBA00038772}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the HSBP1 family.
CC {ECO:0000256|ARBA:ARBA00006349}.
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DR RefSeq; XP_008685785.1; XM_008687563.2.
DR AlphaFoldDB; A0A384BUF1; -.
DR STRING; 29073.ENSUMAP00000032383; -.
DR GeneID; 103659967; -.
DR KEGG; umr:103659967; -.
DR OrthoDB; 11594at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR Gene3D; 1.20.5.430; -; 1.
DR InterPro; IPR009643; HS1-bd.
DR PANTHER; PTHR19424; HEAT SHOCK FACTOR BINDING PROTEIN 1; 1.
DR PANTHER; PTHR19424:SF3; HEAT SHOCK FACTOR-BINDING PROTEIN 1; 1.
DR Pfam; PF06825; HSBP1; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Stress response {ECO:0000313|RefSeq:XP_008685785.1}.
SQ SEQUENCE 82 AA; 9213 MW; 18752EFC2D85A962 CRC64;
MAETDPKTMQ DLTLVVQTVL QQMQDKFQTM SDQIIGRIDD MNSCIGDLEK NIADLMTQAG
VEELESENKI SATPELKMVN LH
//
