GenomeNet

Database: UniProt
Entry: A0A384BUH3_URSMA
LinkDB: A0A384BUH3_URSMA
Original site: A0A384BUH3_URSMA 
ID   A0A384BUH3_URSMA        Unreviewed;      5596 AA.
AC   A0A384BUH3;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   03-AUG-2022, sequence version 2.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143, ECO:0000256|PIRNR:PIRNR010340};
GN   Name=MDN1 {ECO:0000313|RefSeq:XP_008685805.2};
OS   Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008685805.2};
RN   [1] {ECO:0000313|RefSeq:XP_008685805.2}
RP   IDENTIFICATION.
RC   TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008685805.2};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC       of pre-60S ribosome subunits. {ECO:0000256|PIRNR:PIRNR010340}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC       {ECO:0000256|ARBA:ARBA00004642}.
CC   -!- SIMILARITY: Belongs to the midasin family.
CC       {ECO:0000256|ARBA:ARBA00007188, ECO:0000256|PIRNR:PIRNR010340}.
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DR   RefSeq; XP_008685805.2; XM_008687583.2.
DR   STRING; 29073.ENSUMAP00000015393; -.
DR   KEGG; umr:103659982; -.
DR   OrthoDB; 1221059at2759; -.
DR   Proteomes; UP000261680; Unplaced.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0000027; P:ribosomal large subunit assembly; IEA:InterPro.
DR   CDD; cd00009; AAA; 1.
DR   CDD; cd01460; vWA_midasin; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR040848; AAA_lid_7.
DR   InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR   InterPro; IPR029317; KRBA1_rpt.
DR   InterPro; IPR048617; MDN1_AAA_lid_4.
DR   InterPro; IPR012099; Midasin.
DR   InterPro; IPR041190; Midasin_AAA_lid_5.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR   PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR   Pfam; PF07728; AAA_5; 8.
DR   Pfam; PF17865; AAA_lid_5; 1.
DR   Pfam; PF17867; AAA_lid_7; 3.
DR   Pfam; PF21108; MDN1_4th; 1.
DR   PIRSF; PIRSF010340; Midasin; 1.
DR   SMART; SM00382; AAA; 6.
DR   SMART; SM01258; KRBA1; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRNR:PIRNR010340};
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR010340};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR010340};
KW   Nucleus {ECO:0000256|PIRNR:PIRNR010340};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261680}.
FT   DOMAIN          5384..5583
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          514..535
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4314..4335
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4523..4543
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4691..5260
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4691..4738
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4750..4773
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4774..4801
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4804..4893
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4901..4946
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4947..4963
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4964..4995
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        5086..5104
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        5105..5130
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        5186..5201
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        5229..5260
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   5596 AA;  631620 MW;  3B8C152013E201E2 CRC64;
     MEHLFLEVAA TPLRLLAAKN EKSRSELGRF LAKQVWTPQD RQCILNTLAQ LLLDKDCTVL
     VGRQLRPLLL DLLERNAEAI KAGGQVNHDL HERLCVSMSK LIGNHPDVLP FALRYFKDTS
     PVFQRLFLES SDANPVRYGR RRMKLRDLME AAYKFLQQEQ SVFRELWDWS VCVPLLRSHD
     TLVRWYTANC LALVTCMNEE HKLSFLKKIF NSEELIHFRL RLLEEAQLQD LEKALVLANP
     ETSLWRKEKE LQYLQGHLVS ADLSSRVTAV CGVVLPGQQP VPGERASNRS SSREQELAFR
     SYVLVDSICK NLQTLAMAVA SQNAVLLEGP IGCGKTSLVE HLGAMTGRRK PPELLKVQLG
     DQTDSKMLLG MYRCTDVPGE FVWQPGTLTQ AATKGHWILL EDIDYAPLDV VSVLIPLLEN
     GELLIPGRGD CLKVAPGFQF FATRRLLSCG GNWYRPLNSH ATLLDKYWTK IHMDSMDKTE
     LNEVLQNRYP SLLAVTDHLL DIYIQLTGEK HLSQSDSSVT REQAPEEVSE ARRENKRLSL
     EGRELSLRDL LNWCNRIVHC FDSLSSSASL NIFQEALDCF TAMLSKHTSK LKMAEIIGSK
     LNISKKKAEF FCQLYKPEIV INELDVQVGR VRLLRKQSEA VHIQREKLTF APTRPSSVLI
     EQLAVCVSKG EPVLLVGETG TGKTSTVQYL AHITGHRLRV VNMNQQSDTA DLLGGYKPVD
     HKLIWLPLRE AFEELFAQTF SKKQNFTFLG HIQTCYRQKR WHDLLRLMQH VHKSAVNKDG
     KESETGLLLK EKWEAFGLRL NHAQQQMKMT ENALLFAFVE GTLAQAVKKG EWILLDEINL
     AAPETLECLS GLLEGSSGSL VLLDRGDTEP LVRHPDFRLF ACMNPATDVG KRNLPPGIRN
     RFTELYVEEL ESKEDLQILI VDYLKGLSVN KTIVQGIISL YTALRKDSGT KLVDGTGHRP
     HYSLRTLCRA LRFAASNPCS NIQRSLYEGF CLGFLTQLDR ASHPVVQKLI CQHIVSGNVK
     SLLKQPIPEP KGGRLIQVEG YWISVGDKEP TIDETYILTS SVKLNLRDIV RVVSAGTYPV
     LIQGETSVGK TSLIRWLAAA SGNHCVRINN HEHTDIQEYI GCYTSDSSGK LVFKEGVLID
     AMRKGYWIIL DELNLAPTDV LEALNRLLDD NRELLITETQ EVVKAHPRFM LFATQNPPGL
     YGGRKVLSRA FRNRFVELHF DELPSSELET ILHKRCSLPP SYCSKLVKVM LDLQSYRRSS
     SVFAGKQGFI TLRDLFRWAE RYRLAEQTEK EYDWLQHLAN DGFMLLAGRV RKQEEIDVIQ
     EVLEKHFKKK LCPQSLFSKE NVLKLLSKLS TQVSTLESTF SHIVWTEGMR RLAMLVGRAL
     EFGEPVLLVG DTGCGKTTIC QVFAGLANQK LYSVNCHLHM ETSDFLGGLR PVRQKPKDKE
     EIDTSRLFEW HDGPLVLAMK EDGFFLLDEI SLADDSVLER LNSVLEVEKS LVLAEKGSVE
     DKDNEVELLT AGKKFRILAT MNPGGDFGKK ELSPALRNRF TEIWCPQSTN REDLIQVISH
     NLRPGLSLGR IDHKGTDIAE VMLDFIDWLT HQEFGRRCVV SIRDILSWVN FMNTMGEEAA
     LKRPETISTV TSFVHAACLV YIDGIGSGVT SSGFGTALLA RKECLKFLIK KLSKIVRLTE
     CQKNELKIYD RLKAKEFTGM DNLWGIHPFF IPRGPVLHRN NIADYALSAG TTAMNAQRLL
     RATKLNKPIL LEGSPGVGKT SLVGALAKAS GNILVRINLS EQTDITDLFG ADLPVEGGKG
     GEFAWRDGPL LAALKAGHWV VLDELNLASQ SVLEGLNACF DHRGEIYVPE LGMSFQVQHE
     KTKIFGCQNP FRQGGGRKGL PRSFLNRFTQ VFVDPLTVID MEFIASTLFP AIDKNIVKKM
     VAFNNQIDHE VTVEKKWGQK GGPWEFNLRD LFRWCQLMLV DQSPGCYDPG QHVFLVYGER
     MRTKEDKEKV IAVFKDVFNS SSNPYMGTRL FHITPYDVQL GYSVLSRGSY VPLLSRRPLS
     LLHQSLRSLE SIMKCVQMSW MVILVGPASV GKTSLVQLLA HLTGHTLKIM AMNSAMDTTE
     LLGGFEQVDL TRPWRQLLEK VEGTVRALLR DSLLISADDA EVVLRAWSHF LLTYKPKCLG
     DGGKGITMEI VNKLEAVLLL MQRLNNKINS YSKTEFAKLV EEFRNFGVKL LQSTSGHSHG
     TFEWVDSMLV QALKSGDWLL MDNVNFCNPS VLDRLNALLE PGGVLTLSER GMVDGSTPTI
     TPNPNFRLFL SMDPLHGEIS RAMRNRGLEI YISGEGDGNI PDDLDLKVLL HSLGLVGDSV
     CDSLLALHTE IQSTIVGSPT SSISTLIQTA LLIVQYLQRG LSLDKAFSEV CWEAYVCSQH
     SPANQKLVKT LLEKHVSSLR AHETWGNSIL AMGLWPDSLP SALFATEDSH LSIVRSDGQI
     LVYCLNRMSM KTSSWARIQP LTLPDLEKIM QSSNPESLKF SSVEVDTYWI DEPDVLAMAV
     KLLIERATNQ DWMLRVKWLY HLAKNIPQGL ESIQIHLEAN AASLRNFYSN SLSAGVSNVI
     KILQPNITDE FVIPLDPRWN MQALDIIRNS MDFDPQMDQP EQLFALLESV ANKTIIYLDR
     EKRIFTEANL VSVGGKKLRN SVLRMSFEFH KDPESYHSLP HEIVVNLAAF FEFCDALILL
     WVQSSQGMVS DASVIEILES LRWRDRLWTV ADTVKVDAPG LALLALHWHW VLKHLVRQIP
     QLLVNHEDKY FKEVQTVSEH IQNCLGSPTG GFTGIKKLQK FLGRPFPFKN KLVVECFSQL
     KVLNKVLAIR ERMPALGESG WCEDINRLQV VASEWTLKKS LLQAWGLVLR ANVLEDANPD
     ELKNLVNAHC LELKAKGISL GFLEKKHNEA SSLFQLDFTS LIQLTRNVQL WPAMEYLAML
     WQYKVTADFM TQACLRRSSK NQQPQIDEEI SHHITFCLKH TPVAPQELRD LWFLLHCKKV
     STEEVISLWS DLFHSAFMSF WSSTVTTNPE YWLMWSPLPG VQQREVPKSL LDSTLKGPGS
     LSRAVFSKCC FEVLTSSCRA SPWDVSGFPI LSSSHVTLGE WVERALQLRD ISLVLWTNMA
     VPSVAEFRRT DSQLQGLVLC RHLAGLAELL PESQRQEYMQ NCEQLLLGDS QAFQHVGQTL
     GDMAGQEALP KELLCLLLTS LRHFGEGDSK RDLPEPACRG SLWVSLGLLQ IQTWLPQARF
     DPAVKREYKL KYAKEELHQL QCEWKTRNLS SQLLTGRDLE DEVIIHYSHP HIRLLRQRID
     HLENLICSLS KKQAFRPQVP VYESLVQEIH HYVTSIAKAP AVQDLLTRLL QALHMDGPRS
     AQVAQNLLKE EASWQQSHHQ FRKRLAEEYA LYPDSVAPLQ ASILQLQHGM RLVASEVYAS
     FQRSVVCADR LGTLATSLLA FPSVGPAFPT YYAHADALCS VKSEEVLRGL GRLILKRSGG
     KELEGKAQRP CPTREQLLMN ALLYLRSHVL CKGELDQRAL QLFRHVCQEI INEWDEQERI
     AQEKAEQESS LYRCRSRNSR TALSEEEEEE REFRKQFPLH EKDFADILVE PTLEEKKGAS
     DGQEEGATTD PALLSQSSMQ AVMLIHQQLC LSFARSLWYQ QTVPPHETKH YLGLFLSCYQ
     TGASLVTHFY PLMGAELNDQ LLGSQLLACT LSHNTLFGEA VSDLMVKPDG PYDFYQHPNV
     PEARHCQPVL QGFSEAVSQL LQDWPEHPAL EQLLVVMNRI RSFPLSSPIS KFLNGLEILL
     AKAQDWEENA SRALSLRKHL DLVSQMIIRW RKLELNCWSM SLDNTMKRHT EKSTKHWFSI
     YQMLEKHMQE QTEEQEDDKQ MTLMLLVSTL QAFIEGSSLG EFHVRLQMLL VFHCHVLLMP
     QVEGKDALCS VLWNLYHYYK QFFDRVQAKI VELRSPLEKE LKEFVKISKW SDVSFWSIKQ
     SVEKTHRTLF KFMKKFEAVL SEPCRSSLVE SDKEEQPDFL SWPAATSEAS PVQSLNKALK
     ETLLARPAAA QAVIPEQCQG APFSSEGELL RRLPKLMKRM RKMCLTLMKE SRLPHLVEGL
     DHFTGEVISC VSELQSLKVE PSAEKEKQRS EAKHILLRKQ RALADLFQQL AKTGLSYRKG
     LAWARSKNPQ EMLHLHPLEI RSALSIVSST QEADSGLLTE ISSSWDGCQK YFFRSLARHA
     RLSAALAAPA KELGMSNVER CRGFSAHLMK MLIRQRRSLT TLTEQWILLR NLLGCVQEIH
     GRLTGPLVYP VAFPPQDGVQ QWTERLQHLA MQSQVLLEQL SWFLQCCPCA GPTPGQGEAQ
     AQGQPSAPYP EGPELTKGWL SGAAQDLIPS ELSYPSPVPR NQLPSGCRMR KQDQLWQQST
     TRLTEMLKTI KTVKADVDKI RQQSCETLFH SWKDFEVCSS GLSCLSQMSV HLQGLESLFV
     IPGREVKQTD QQMALVQSLE YLRGEINKAT DEFTAWKTHL LALGSQGGNQ MLEEGFVEDF
     SERVEAAIRA ILCAIQNLAE RNSKKTEENT DQTGPREEDE AAGCERLQSG HLTKLLEDDL
     WADVSALHVQ KIISAVSELL ERLKSYGEDG IAAKNTVFSQ SCCLLVRLVP MLSRYSDLVL
     FFLTMSLATH RSTAKLLSVL AQVFTELAQE GFCLPKEFME DSAGEGATEF HDYEGGGIGE
     GEGVKDVSDQ IEHEDQAEDT FQKGQEKDKE DPDSKSDIKG EDNAIEMSED FDGKMHDGEL
     EEQEEDDGKS DSEGRDLDKQ MGDLNGEEAD KLDERLWGDD DEEEDEEEED SKTEETGPGM
     DEEDCGLVAK DDNLDAGKSN RDKNQDKKEE KEEAEVADDG QGQDKINEQI DEREYDENEV
     DPYHGNQEKL PEPEALDLPD DLNLDSEDKN GSEDTDHEEG EENPLEIKEK PMDTEEAGRE
     AEEIKEEIEA DHSEGQSQHE AEEGSSEEEK GEGEEEMDTG ADDQDKDTAE HPEENSDDEW
     QSLEDKDKEA SEDSAENGVP VDQGLQPQKQ EEEEGGENSD PEEQVPEATE RKEHASCGQT
     GVESVQSAQA VELAGTAPEK EQGKEEHGSG AADANQAEGH ESSFIARLAS QKQTRKNTQS
     FKRKPGQADN ERSVGDHNEH VHKRLRTVDV ESQAEQGPAQ PPARVEDADA FEHVKEGSGP
     YDAQTYDVAS KEQQQSAKDS SRDQEEEIED TFADVEEEEL RAADVEQLKP EVVTSGTTAS
     PGLDEMEVET QAVKTEDQDP RTNLSHEETE KEKPERSRDS TIHTAHQFLM DTVFQPFLKD
     IGELRQELER QLEMWQPHES GNPEEEKAAA EMWQSYLALT APLSQQLCEQ LRLILEPTQA
     AKLKGDYRTG KRLNMRKVIP YVASQFRKDK IWLRRTKPSK RQYQICLAID DSSSMVDNHT
     KQLAFESLAV IGNALALLEA GQIAVCSFGE SVKLLHPFHE QFSDSSGSQI LRLCKFQQKK
     TKIAQFLESV ARMFAAAQQP SQNASPETAQ LLLVVSDGRG LFLEGKDRVL AAVRAARNAN
     IFVIFVVLDN PSSRDSILDI KVPIFKGPGE MPEIRSYMEE FPFPFYIILR DVNALPETLS
     DALRQWFELV AASDHP
//
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