ID A0A384BUH3_URSMA Unreviewed; 5596 AA.
AC A0A384BUH3;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 03-AUG-2022, sequence version 2.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143, ECO:0000256|PIRNR:PIRNR010340};
GN Name=MDN1 {ECO:0000313|RefSeq:XP_008685805.2};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008685805.2};
RN [1] {ECO:0000313|RefSeq:XP_008685805.2}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008685805.2};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC of pre-60S ribosome subunits. {ECO:0000256|PIRNR:PIRNR010340}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the midasin family.
CC {ECO:0000256|ARBA:ARBA00007188, ECO:0000256|PIRNR:PIRNR010340}.
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DR RefSeq; XP_008685805.2; XM_008687583.2.
DR STRING; 29073.ENSUMAP00000015393; -.
DR KEGG; umr:103659982; -.
DR OrthoDB; 1221059at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0000027; P:ribosomal large subunit assembly; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR CDD; cd01460; vWA_midasin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR029317; KRBA1_rpt.
DR InterPro; IPR048617; MDN1_AAA_lid_4.
DR InterPro; IPR012099; Midasin.
DR InterPro; IPR041190; Midasin_AAA_lid_5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF07728; AAA_5; 8.
DR Pfam; PF17865; AAA_lid_5; 1.
DR Pfam; PF17867; AAA_lid_7; 3.
DR Pfam; PF21108; MDN1_4th; 1.
DR PIRSF; PIRSF010340; Midasin; 1.
DR SMART; SM00382; AAA; 6.
DR SMART; SM01258; KRBA1; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRNR:PIRNR010340};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR010340};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR010340};
KW Nucleus {ECO:0000256|PIRNR:PIRNR010340};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680}.
FT DOMAIN 5384..5583
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 514..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4314..4335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4523..4543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4691..5260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4691..4738
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4750..4773
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4774..4801
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4804..4893
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4901..4946
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4947..4963
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4964..4995
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5086..5104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5105..5130
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5186..5201
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5229..5260
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5596 AA; 631620 MW; 3B8C152013E201E2 CRC64;
MEHLFLEVAA TPLRLLAAKN EKSRSELGRF LAKQVWTPQD RQCILNTLAQ LLLDKDCTVL
VGRQLRPLLL DLLERNAEAI KAGGQVNHDL HERLCVSMSK LIGNHPDVLP FALRYFKDTS
PVFQRLFLES SDANPVRYGR RRMKLRDLME AAYKFLQQEQ SVFRELWDWS VCVPLLRSHD
TLVRWYTANC LALVTCMNEE HKLSFLKKIF NSEELIHFRL RLLEEAQLQD LEKALVLANP
ETSLWRKEKE LQYLQGHLVS ADLSSRVTAV CGVVLPGQQP VPGERASNRS SSREQELAFR
SYVLVDSICK NLQTLAMAVA SQNAVLLEGP IGCGKTSLVE HLGAMTGRRK PPELLKVQLG
DQTDSKMLLG MYRCTDVPGE FVWQPGTLTQ AATKGHWILL EDIDYAPLDV VSVLIPLLEN
GELLIPGRGD CLKVAPGFQF FATRRLLSCG GNWYRPLNSH ATLLDKYWTK IHMDSMDKTE
LNEVLQNRYP SLLAVTDHLL DIYIQLTGEK HLSQSDSSVT REQAPEEVSE ARRENKRLSL
EGRELSLRDL LNWCNRIVHC FDSLSSSASL NIFQEALDCF TAMLSKHTSK LKMAEIIGSK
LNISKKKAEF FCQLYKPEIV INELDVQVGR VRLLRKQSEA VHIQREKLTF APTRPSSVLI
EQLAVCVSKG EPVLLVGETG TGKTSTVQYL AHITGHRLRV VNMNQQSDTA DLLGGYKPVD
HKLIWLPLRE AFEELFAQTF SKKQNFTFLG HIQTCYRQKR WHDLLRLMQH VHKSAVNKDG
KESETGLLLK EKWEAFGLRL NHAQQQMKMT ENALLFAFVE GTLAQAVKKG EWILLDEINL
AAPETLECLS GLLEGSSGSL VLLDRGDTEP LVRHPDFRLF ACMNPATDVG KRNLPPGIRN
RFTELYVEEL ESKEDLQILI VDYLKGLSVN KTIVQGIISL YTALRKDSGT KLVDGTGHRP
HYSLRTLCRA LRFAASNPCS NIQRSLYEGF CLGFLTQLDR ASHPVVQKLI CQHIVSGNVK
SLLKQPIPEP KGGRLIQVEG YWISVGDKEP TIDETYILTS SVKLNLRDIV RVVSAGTYPV
LIQGETSVGK TSLIRWLAAA SGNHCVRINN HEHTDIQEYI GCYTSDSSGK LVFKEGVLID
AMRKGYWIIL DELNLAPTDV LEALNRLLDD NRELLITETQ EVVKAHPRFM LFATQNPPGL
YGGRKVLSRA FRNRFVELHF DELPSSELET ILHKRCSLPP SYCSKLVKVM LDLQSYRRSS
SVFAGKQGFI TLRDLFRWAE RYRLAEQTEK EYDWLQHLAN DGFMLLAGRV RKQEEIDVIQ
EVLEKHFKKK LCPQSLFSKE NVLKLLSKLS TQVSTLESTF SHIVWTEGMR RLAMLVGRAL
EFGEPVLLVG DTGCGKTTIC QVFAGLANQK LYSVNCHLHM ETSDFLGGLR PVRQKPKDKE
EIDTSRLFEW HDGPLVLAMK EDGFFLLDEI SLADDSVLER LNSVLEVEKS LVLAEKGSVE
DKDNEVELLT AGKKFRILAT MNPGGDFGKK ELSPALRNRF TEIWCPQSTN REDLIQVISH
NLRPGLSLGR IDHKGTDIAE VMLDFIDWLT HQEFGRRCVV SIRDILSWVN FMNTMGEEAA
LKRPETISTV TSFVHAACLV YIDGIGSGVT SSGFGTALLA RKECLKFLIK KLSKIVRLTE
CQKNELKIYD RLKAKEFTGM DNLWGIHPFF IPRGPVLHRN NIADYALSAG TTAMNAQRLL
RATKLNKPIL LEGSPGVGKT SLVGALAKAS GNILVRINLS EQTDITDLFG ADLPVEGGKG
GEFAWRDGPL LAALKAGHWV VLDELNLASQ SVLEGLNACF DHRGEIYVPE LGMSFQVQHE
KTKIFGCQNP FRQGGGRKGL PRSFLNRFTQ VFVDPLTVID MEFIASTLFP AIDKNIVKKM
VAFNNQIDHE VTVEKKWGQK GGPWEFNLRD LFRWCQLMLV DQSPGCYDPG QHVFLVYGER
MRTKEDKEKV IAVFKDVFNS SSNPYMGTRL FHITPYDVQL GYSVLSRGSY VPLLSRRPLS
LLHQSLRSLE SIMKCVQMSW MVILVGPASV GKTSLVQLLA HLTGHTLKIM AMNSAMDTTE
LLGGFEQVDL TRPWRQLLEK VEGTVRALLR DSLLISADDA EVVLRAWSHF LLTYKPKCLG
DGGKGITMEI VNKLEAVLLL MQRLNNKINS YSKTEFAKLV EEFRNFGVKL LQSTSGHSHG
TFEWVDSMLV QALKSGDWLL MDNVNFCNPS VLDRLNALLE PGGVLTLSER GMVDGSTPTI
TPNPNFRLFL SMDPLHGEIS RAMRNRGLEI YISGEGDGNI PDDLDLKVLL HSLGLVGDSV
CDSLLALHTE IQSTIVGSPT SSISTLIQTA LLIVQYLQRG LSLDKAFSEV CWEAYVCSQH
SPANQKLVKT LLEKHVSSLR AHETWGNSIL AMGLWPDSLP SALFATEDSH LSIVRSDGQI
LVYCLNRMSM KTSSWARIQP LTLPDLEKIM QSSNPESLKF SSVEVDTYWI DEPDVLAMAV
KLLIERATNQ DWMLRVKWLY HLAKNIPQGL ESIQIHLEAN AASLRNFYSN SLSAGVSNVI
KILQPNITDE FVIPLDPRWN MQALDIIRNS MDFDPQMDQP EQLFALLESV ANKTIIYLDR
EKRIFTEANL VSVGGKKLRN SVLRMSFEFH KDPESYHSLP HEIVVNLAAF FEFCDALILL
WVQSSQGMVS DASVIEILES LRWRDRLWTV ADTVKVDAPG LALLALHWHW VLKHLVRQIP
QLLVNHEDKY FKEVQTVSEH IQNCLGSPTG GFTGIKKLQK FLGRPFPFKN KLVVECFSQL
KVLNKVLAIR ERMPALGESG WCEDINRLQV VASEWTLKKS LLQAWGLVLR ANVLEDANPD
ELKNLVNAHC LELKAKGISL GFLEKKHNEA SSLFQLDFTS LIQLTRNVQL WPAMEYLAML
WQYKVTADFM TQACLRRSSK NQQPQIDEEI SHHITFCLKH TPVAPQELRD LWFLLHCKKV
STEEVISLWS DLFHSAFMSF WSSTVTTNPE YWLMWSPLPG VQQREVPKSL LDSTLKGPGS
LSRAVFSKCC FEVLTSSCRA SPWDVSGFPI LSSSHVTLGE WVERALQLRD ISLVLWTNMA
VPSVAEFRRT DSQLQGLVLC RHLAGLAELL PESQRQEYMQ NCEQLLLGDS QAFQHVGQTL
GDMAGQEALP KELLCLLLTS LRHFGEGDSK RDLPEPACRG SLWVSLGLLQ IQTWLPQARF
DPAVKREYKL KYAKEELHQL QCEWKTRNLS SQLLTGRDLE DEVIIHYSHP HIRLLRQRID
HLENLICSLS KKQAFRPQVP VYESLVQEIH HYVTSIAKAP AVQDLLTRLL QALHMDGPRS
AQVAQNLLKE EASWQQSHHQ FRKRLAEEYA LYPDSVAPLQ ASILQLQHGM RLVASEVYAS
FQRSVVCADR LGTLATSLLA FPSVGPAFPT YYAHADALCS VKSEEVLRGL GRLILKRSGG
KELEGKAQRP CPTREQLLMN ALLYLRSHVL CKGELDQRAL QLFRHVCQEI INEWDEQERI
AQEKAEQESS LYRCRSRNSR TALSEEEEEE REFRKQFPLH EKDFADILVE PTLEEKKGAS
DGQEEGATTD PALLSQSSMQ AVMLIHQQLC LSFARSLWYQ QTVPPHETKH YLGLFLSCYQ
TGASLVTHFY PLMGAELNDQ LLGSQLLACT LSHNTLFGEA VSDLMVKPDG PYDFYQHPNV
PEARHCQPVL QGFSEAVSQL LQDWPEHPAL EQLLVVMNRI RSFPLSSPIS KFLNGLEILL
AKAQDWEENA SRALSLRKHL DLVSQMIIRW RKLELNCWSM SLDNTMKRHT EKSTKHWFSI
YQMLEKHMQE QTEEQEDDKQ MTLMLLVSTL QAFIEGSSLG EFHVRLQMLL VFHCHVLLMP
QVEGKDALCS VLWNLYHYYK QFFDRVQAKI VELRSPLEKE LKEFVKISKW SDVSFWSIKQ
SVEKTHRTLF KFMKKFEAVL SEPCRSSLVE SDKEEQPDFL SWPAATSEAS PVQSLNKALK
ETLLARPAAA QAVIPEQCQG APFSSEGELL RRLPKLMKRM RKMCLTLMKE SRLPHLVEGL
DHFTGEVISC VSELQSLKVE PSAEKEKQRS EAKHILLRKQ RALADLFQQL AKTGLSYRKG
LAWARSKNPQ EMLHLHPLEI RSALSIVSST QEADSGLLTE ISSSWDGCQK YFFRSLARHA
RLSAALAAPA KELGMSNVER CRGFSAHLMK MLIRQRRSLT TLTEQWILLR NLLGCVQEIH
GRLTGPLVYP VAFPPQDGVQ QWTERLQHLA MQSQVLLEQL SWFLQCCPCA GPTPGQGEAQ
AQGQPSAPYP EGPELTKGWL SGAAQDLIPS ELSYPSPVPR NQLPSGCRMR KQDQLWQQST
TRLTEMLKTI KTVKADVDKI RQQSCETLFH SWKDFEVCSS GLSCLSQMSV HLQGLESLFV
IPGREVKQTD QQMALVQSLE YLRGEINKAT DEFTAWKTHL LALGSQGGNQ MLEEGFVEDF
SERVEAAIRA ILCAIQNLAE RNSKKTEENT DQTGPREEDE AAGCERLQSG HLTKLLEDDL
WADVSALHVQ KIISAVSELL ERLKSYGEDG IAAKNTVFSQ SCCLLVRLVP MLSRYSDLVL
FFLTMSLATH RSTAKLLSVL AQVFTELAQE GFCLPKEFME DSAGEGATEF HDYEGGGIGE
GEGVKDVSDQ IEHEDQAEDT FQKGQEKDKE DPDSKSDIKG EDNAIEMSED FDGKMHDGEL
EEQEEDDGKS DSEGRDLDKQ MGDLNGEEAD KLDERLWGDD DEEEDEEEED SKTEETGPGM
DEEDCGLVAK DDNLDAGKSN RDKNQDKKEE KEEAEVADDG QGQDKINEQI DEREYDENEV
DPYHGNQEKL PEPEALDLPD DLNLDSEDKN GSEDTDHEEG EENPLEIKEK PMDTEEAGRE
AEEIKEEIEA DHSEGQSQHE AEEGSSEEEK GEGEEEMDTG ADDQDKDTAE HPEENSDDEW
QSLEDKDKEA SEDSAENGVP VDQGLQPQKQ EEEEGGENSD PEEQVPEATE RKEHASCGQT
GVESVQSAQA VELAGTAPEK EQGKEEHGSG AADANQAEGH ESSFIARLAS QKQTRKNTQS
FKRKPGQADN ERSVGDHNEH VHKRLRTVDV ESQAEQGPAQ PPARVEDADA FEHVKEGSGP
YDAQTYDVAS KEQQQSAKDS SRDQEEEIED TFADVEEEEL RAADVEQLKP EVVTSGTTAS
PGLDEMEVET QAVKTEDQDP RTNLSHEETE KEKPERSRDS TIHTAHQFLM DTVFQPFLKD
IGELRQELER QLEMWQPHES GNPEEEKAAA EMWQSYLALT APLSQQLCEQ LRLILEPTQA
AKLKGDYRTG KRLNMRKVIP YVASQFRKDK IWLRRTKPSK RQYQICLAID DSSSMVDNHT
KQLAFESLAV IGNALALLEA GQIAVCSFGE SVKLLHPFHE QFSDSSGSQI LRLCKFQQKK
TKIAQFLESV ARMFAAAQQP SQNASPETAQ LLLVVSDGRG LFLEGKDRVL AAVRAARNAN
IFVIFVVLDN PSSRDSILDI KVPIFKGPGE MPEIRSYMEE FPFPFYIILR DVNALPETLS
DALRQWFELV AASDHP
//