ID A0A384BXZ3_URSMA Unreviewed; 169 AA.
AC A0A384BXZ3;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Protein phosphatase 1 regulatory subunit 1B {ECO:0000256|ARBA:ARBA00020090};
DE AltName: Full=DARPP-32 {ECO:0000256|ARBA:ARBA00029874};
DE AltName: Full=Dopamine- and cAMP-regulated neuronal phosphoprotein {ECO:0000256|ARBA:ARBA00030254};
GN Name=PPP1R1B {ECO:0000313|Ensembl:ENSUMAP00000023847};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Ensembl:ENSUMAP00000023847};
RN [1] {ECO:0000313|Ensembl:ENSUMAP00000023847}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
CC -!- FUNCTION: Inhibitor of protein-phosphatase 1.
CC {ECO:0000256|ARBA:ARBA00002900}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the protein phosphatase inhibitor 1 family.
CC {ECO:0000256|ARBA:ARBA00007775}.
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DR RefSeq; XP_008687442.1; XM_008689220.1.
DR RefSeq; XP_008687446.1; XM_008689224.1.
DR RefSeq; XP_008687452.1; XM_008689230.1.
DR AlphaFoldDB; A0A384BXZ3; -.
DR STRING; 29073.ENSUMAP00000023847; -.
DR Ensembl; ENSUMAT00000028238.1; ENSUMAP00000023847.1; ENSUMAG00000017350.1.
DR Ensembl; ENSUMAT00000028242.1; ENSUMAP00000023851.1; ENSUMAG00000017350.1.
DR OMA; EDPCEGD; -.
DR OrthoDB; 4018581at2759; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:Ensembl.
DR GO; GO:0048148; P:behavioral response to cocaine; IEA:Ensembl.
DR GO; GO:0071314; P:cellular response to cocaine; IEA:Ensembl.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR GO; GO:0007621; P:negative regulation of female receptivity; IEA:Ensembl.
DR GO; GO:0001975; P:response to amphetamine; IEA:Ensembl.
DR GO; GO:0043278; P:response to morphine; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR GO; GO:0008542; P:visual learning; IEA:Ensembl.
DR InterPro; IPR008466; PPP1R1A/B/C.
DR PANTHER; PTHR15417:SF2; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 1B; 1.
DR PANTHER; PTHR15417; PROTEIN PHOSPHATASE INHIBITOR AND DOPAMINE- AND CAMP-REGULATED NEURONAL PHOSPHOPROTEIN; 1.
DR Pfam; PF05395; DARPP-32; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT REGION 1..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..31
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..63
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..103
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 169 AA; 18823 MW; 26C0ABFEB0B2324D CRC64;
MLFRLSEHSS PEEEASPHQR ASGEGHHLKS KRPNPCAYTP PSLKAVQRIA ESHLQSISNL
NENQASEEED ELGELRELGY PREEDEEEEE DDDEEEEEEE DSQAEVLKGC RGPAGQKTAC
GQGLEGPWER PPPLDEPQRD GSSKEQVEDP ALNEPGEEPQ RPAHPEPGT
//
