ID A0A384BYY1_URSMA Unreviewed; 270 AA.
AC A0A384BYY1;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Dickkopf WNT signaling pathway inhibitor 1 {ECO:0000313|Ensembl:ENSUMAP00000014930};
DE SubName: Full=Dickkopf-related protein 1 {ECO:0000313|RefSeq:XP_008687801.1};
GN Name=DKK1 {ECO:0000313|Ensembl:ENSUMAP00000014930,
GN ECO:0000313|RefSeq:XP_008687801.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008687801.1};
RN [1] {ECO:0000313|Ensembl:ENSUMAP00000014930}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008687801.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008687801.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the dickkopf family.
CC {ECO:0000256|ARBA:ARBA00010842}.
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DR RefSeq; XP_008687801.1; XM_008689579.2.
DR STRING; 29073.ENSUMAP00000014930; -.
DR Ensembl; ENSUMAT00000017685.1; ENSUMAP00000014930.1; ENSUMAG00000010974.1.
DR GeneID; 103661909; -.
DR KEGG; umr:103661909; -.
DR CTD; 22943; -.
DR OMA; LDNYQPY; -.
DR OrthoDB; 4329885at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0039706; F:co-receptor binding; IEA:Ensembl.
DR GO; GO:0050750; F:low-density lipoprotein particle receptor binding; IEA:Ensembl.
DR GO; GO:0048019; F:receptor antagonist activity; IEA:Ensembl.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:2000726; P:negative regulation of cardiac muscle cell differentiation; IEA:Ensembl.
DR GO; GO:0042662; P:negative regulation of mesodermal cell fate specification; IEA:Ensembl.
DR GO; GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
DR GO; GO:0060392; P:negative regulation of SMAD protein signal transduction; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:1904723; P:negative regulation of Wnt-Frizzled-LRP5/6 complex assembly; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR GO; GO:0042663; P:regulation of endodermal cell fate specification; IEA:Ensembl.
DR GO; GO:0002090; P:regulation of receptor internalization; IEA:Ensembl.
DR CDD; cd23272; Dkk1_Cys2; 1.
DR CDD; cd23026; Dkk1_N_Cys1; 1.
DR Gene3D; 2.10.80.10; Lipase, subunit A; 1.
DR InterPro; IPR006796; Dickkopf_N.
DR InterPro; IPR048500; DIKK1/2/4_C-subdom1.
DR InterPro; IPR048499; DIKK1/2/4_C-subdom2.
DR InterPro; IPR039863; DKK1-4.
DR InterPro; IPR047304; Dkk1_Cys2.
DR InterPro; IPR047305; Dkk1_N.
DR PANTHER; PTHR12113:SF11; DICKKOPF-RELATED PROTEIN 1; 1.
DR PANTHER; PTHR12113; DICKKOPF3-LIKE 3; 1.
DR Pfam; PF04706; Dickkopf_N; 1.
DR Pfam; PF21481; DIKK1-2-4_C-subdom1; 1.
DR Pfam; PF21479; DIKK1-2-4_C-subdom2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..270
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041072171"
FT DOMAIN 86..142
FT /note="Dickkopf N-terminal cysteine-rich"
FT /evidence="ECO:0000259|Pfam:PF04706"
FT DOMAIN 189..218
FT /note="Dickkopf-related protein 1/2/4 C-terminal subdomain
FT 1"
FT /evidence="ECO:0000259|Pfam:PF21481"
FT DOMAIN 221..270
FT /note="Dickkopf-related protein 1/2/4 C-terminal subdomain
FT 2"
FT /evidence="ECO:0000259|Pfam:PF21479"
SQ SEQUENCE 270 AA; 29019 MW; 9EC152F1124A1B3B CRC64;
MTALGAVGAA RVLAALIAVA LCGHLQLGVS ATLNSVLVNS NAIKNLPPAL GGAAGHLGSA
VSASPGIPYE GGNKYQTFDN DPPYPCAEDE ECSTEEYCAS PSRGGGAGAG AQICLACRKR
RKRCMRHAMC CPGNYCKNGI CMPSDHNHFH REEIEETILE SVGNDHSTVD GYSRRTTLSS
KLYHTKGQEG SVCLRSSDCA TGLCCARHFW SKICKPVLKE GQVCTKHRRK GSHGLEIFQR
CYCGEGLSCR IQNDHHQASN SSRLHTCQRH
//
