ID A0A384BZQ3_URSMA Unreviewed; 1968 AA.
AC A0A384BZQ3;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Multiple PDZ domain protein isoform X6 {ECO:0000313|RefSeq:XP_008688072.1};
GN Name=MPDZ {ECO:0000313|RefSeq:XP_008688072.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008688072.1};
RN [1] {ECO:0000313|RefSeq:XP_008688072.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008688072.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004202}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004202}.
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DR RefSeq; XP_008688072.1; XM_008689850.2.
DR GeneID; 103662184; -.
DR CTD; 8777; -.
DR OrthoDB; 2911488at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 13.
DR Gene3D; 2.30.42.10; -; 13.
DR Gene3D; 1.10.287.650; L27 domain; 1.
DR InterPro; IPR015132; L27_2.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR032078; MPDZ_u10.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR19964; MULTIPLE PDZ DOMAIN PROTEIN; 1.
DR PANTHER; PTHR19964:SF44; PATJ HOMOLOG; 1.
DR Pfam; PF09045; L27_2; 1.
DR Pfam; PF16667; MPDZ_u10; 1.
DR Pfam; PF00595; PDZ; 13.
DR SMART; SM00569; L27; 1.
DR SMART; SM00228; PDZ; 13.
DR SUPFAM; SSF101288; L27 domain; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 13.
DR PROSITE; PS51022; L27; 1.
DR PROSITE; PS50106; PDZ; 13.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022427};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 3..63
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 137..224
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 257..337
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 377..463
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 559..640
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 706..781
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 976..1044
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1119..1178
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1248..1331
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1381..1462
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1527..1610
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1623..1705
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1760..1846
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1885..1968
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 342..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 466..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1089..1111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1162..1199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1341..1366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1467..1508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1708..1732
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1472..1508
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1712..1732
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1968 AA; 209639 MW; 4251DE6A57950059 CRC64;
MLETIDKNRA LQAAERLQAK LRERGDVANE DKLNLLKSVL QSPLFSQILN LQTSVQQLKD
QVNTTTSAIS NVEYAHIPHP SPAVIPTLQN ELFLSSSNNG NLEAFTGSGT PHVSGKPACD
EFDQLIKNMA QGRHVEVFEL LKPPCGGLGF SVVGLRSENR GELGIFVQEI QEGSVAHRDG
RLKETDQILA INGQALDQTI THQQAISILQ KAKDNVQLVI ARGSLPQLIS PIVSRSPSAA
STVSAHSNPV HWQHVETIEL VNDGSGLGFG IVGGKATGVI VKTILPGGVA DQHGRLCSGD
HILKIGDTDL AGMSSEQVAQ VLRQCGNRVK LTIARGATEE PAAPTSLGIT VSSSPPSTPE
MRVDASTQKS EESETFDVEL TKNVHGLGIT IAGYIGDKKL EPSGIFVKSI TKSSAVEHDG
RIQIGDQIIA VDGTNLQGFT NQQAVEVLRH TGPTVHLTLM RRGAKQEAEL TSREDVTKEA
VVSPVNASGS KENYEKDEDS SSLSRNTSIL PNEEEGKHLE PGYPLLSAEI EDIEDARQQE
AALLTKWQRI MGINYEIVVA HVSKFSENSG LGISLEATVG HHFIRSVLPE GPVGHSGKLF
SGDELLEVNG ITLLGENHQD VVNILKELPI EVAMVCCRRT VPPTSQSGVD SLDLRDIELT
EKPHVDLGEF TGSSETEEAV LAVTDVGQNV EEVQGPLAMW EVDVQHIELE KGNKGLGFSI
LDYQDPIDPA STVIVIRSLV PGGIAEKDGR LLPGDRLMFV NDVNLENSSL EEAVQALKGA
PPGTVRIGVA KPLPVDTNEA DLADESTFES QYSPDNDSIY STQASILSLH GSACSDGLNY
GPSLPSSPPK DVTENSSAPV LDLHMSLEDL YTQNLLQRQD ESPSSVDLSL GPASGFTVND
YTPANAIEQQ YKCENTRTWA ESHLPNEMIS SAELTAPVLP DSTGKGSEFL IQQSSLTSSA
ECVMLQNLSK ESFERTITIA KGNSSLGMTV SANKDGLGMI VRSIIHGGSI SRDGRIAVGD
CILSINEEST ISLTNAQARA MLRRHSLIGP DIKITYVPAE HLEEFKISLG QQSGGIMALD
VFSSYSGRDI PELPEREEGE GEESELQNAA YSNWNQPRRV ELWREPSKSL GISIVGGRGM
GSRLSNGEVM RGIFIKHVLE DSPAGKNGTL KPGDRIVEAP SQSESEPEKA PLCNVPPPPS
SAFAEMSGDL TQSSASKISE DVDKEDEFGY SWKNIRERYG TLTGELHMIE LEKGRSGLGL
SLAGNKDRSR MSVFVVGIDP NGAAGKDGRL QIADELLEIN GQILYGRSHQ NASSIIKCAP
SKVKIIFIRN KDAVSQMAVC PGNTVDPVPS TSENSRNKEA ERSDTTSDAA VDLCSFKNVQ
HLELPKDQGG LGIAISEEDT LSGVIIKSLT EHGVAAKDGR LKVGDQILAI DDEVVVGYPV
EKFISLLKTA KTTVKLSIRA ENHDPQAVAS AAGTASGEQK SSSLSPTAPS SGSPEPESIP
STSRSSTPAI FASDPATCPI IPGCETTIEI SKGRTGLGLS IVGGSDTLLG AIIIHEVYEE
GAACKDGRLW AGDQILEVNG IDLRKATHDE AINVLRQTPQ RVRLTLYRDE APYKEEDVYD
TLTVELQKKP GKGLGLSIVG KRNDTGVFVS DIVKGGIADA DGRLVQGDQI LTVNGEDVRN
ATQEAVAALL KCSLGTVTLE VGRIKAGPFH SERRPSQSSQ MSEGSLSSFT FPLSGSSTSE
SLESSLKKNA LASEIQGLRT VEIKKGPTDS LGISIAGGVG SPLGDVPIFI AMMHPNGVAA
QTQKLRVGDR IVTICGTSTE GMTHTQAVNL LKNAPGSIEM QVAAGGDVSV VTGHQQEPAS
SSLSFTGLTS SSIFQDDLGP PQCKSITLDR GPDGLGFSIV GGYGSPHGDL PIYVKTVFAK
GAASEDGRLK RGDQIIAVNG QSLEGVTHEE AVAILKRTKG TVTLMVLS
//
