ID A0A384BZW8_URSMA Unreviewed; 568 AA.
AC A0A384BZW8;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 03-AUG-2022, sequence version 2.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Protein NDNF {ECO:0000256|ARBA:ARBA00024096};
GN Name=NDNF {ECO:0000313|RefSeq:XP_008687700.2};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008687700.2};
RN [1] {ECO:0000313|RefSeq:XP_008687700.2}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008687700.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR RefSeq; XP_008687700.2; XM_008689478.2.
DR AlphaFoldDB; A0A384BZW8; -.
DR STRING; 29073.ENSUMAP00000004729; -.
DR KEGG; umr:103661790; -.
DR OrthoDB; 2876995at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0031012; C:extracellular matrix; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0008201; F:heparin binding; IEA:Ensembl.
DR GO; GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEA:Ensembl.
DR GO; GO:0071456; P:cellular response to hypoxia; IEA:Ensembl.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl.
DR GO; GO:0021828; P:gonadotrophin-releasing hormone neuronal migration to the hypothalamus; IEA:Ensembl.
DR GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; IEA:Ensembl.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0007263; P:nitric oxide mediated signal transduction; IEA:Ensembl.
DR GO; GO:0010811; P:positive regulation of cell-substrate adhesion; IEA:Ensembl.
DR GO; GO:0010976; P:positive regulation of neuron projection development; IEA:Ensembl.
DR GO; GO:0002931; P:response to ischemia; IEA:Ensembl.
DR GO; GO:0061042; P:vascular wound healing; IEA:Ensembl.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR019326; NDNF.
DR InterPro; IPR045805; NDNF_C.
DR PANTHER; PTHR14619; NEURON-DERIVED NEUROTROPHIC FACTOR; 1.
DR PANTHER; PTHR14619:SF1; PROTEIN NDNF; 1.
DR Pfam; PF10179; NDNF; 1.
DR Pfam; PF19433; NDNF_C; 1.
DR SMART; SM00060; FN3; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..568
FT /note="Protein NDNF"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5035481507"
FT DOMAIN 174..325
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|SMART:SM00060"
FT DOMAIN 445..554
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|SMART:SM00060"
SQ SEQUENCE 568 AA; 64555 MW; 5EB0794319B817CC CRC64;
MVPLHWCLLW LLLPLSLRTQ KLPTRDEELF QMQIRDKAFF HDSSVIPDGA EINSYLFRDT
PKRYFFVVEE DNTPLSVTVT PCDAPLEWKL SLQELPEEAS GDGSGDPEPL EQQRQQITNE
EGTELFSYKG NDVEYFISSS SPSGLYQLEL LSTEKDTHFK VYATTTPESD QPYPELPYDP
RVDVTSLGRT TVTLAWKPSP TASLLRQPIQ YCVVINKEHN FKSLCAVEAK LSADDAFMMA
PKPGLDFSPF DFAHFGFPSE NSGKDRSFLA KPSPKLGRHV YSRPKVDIQK ICIGNKNIFT
VSDLKPDTQY YFDVFVANSN SNMSTAYVGT FARTKEEAKQ KTVELKDGKV TDVFVKRKGA
KFLRFAPVSS HQKVTFFIHS CLDAIQIQVR RDGKLLLSQN VEGIRQFQLR GKPKAKYLIR
LKGHKKGASM LKILATTRPS KQPFPALPED TRIKAFDKLR TCSSATVAWL GTQERNKFCI
YKKEVDDSYN EDQKKREQNQ CLGPDTRKKS EKVLCKYFHS QNLQKAVTTE TIKGLLPGKS
YLLDVYVIGH GGHSVKYQSK VVKTRKFC
//
