ID A0A384C2Q5_URSMA Unreviewed; 459 AA.
AC A0A384C2Q5;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=E3 ubiquitin-protein ligase RNF25 isoform X1 {ECO:0000313|RefSeq:XP_008688685.1};
DE SubName: Full=Ring finger protein 25 {ECO:0000313|Ensembl:ENSUMAP00000026788};
GN Name=RNF25 {ECO:0000313|Ensembl:ENSUMAP00000026788,
GN ECO:0000313|RefSeq:XP_008688685.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008688685.1};
RN [1] {ECO:0000313|Ensembl:ENSUMAP00000026788}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008688685.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008688685.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_008688685.1; XM_008690463.2.
DR STRING; 29073.ENSUMAP00000026788; -.
DR Ensembl; ENSUMAT00000031709.1; ENSUMAP00000026788.1; ENSUMAG00000019502.1.
DR GeneID; 103662757; -.
DR KEGG; umr:103662757; -.
DR CTD; 64320; -.
DR OMA; PWEISIT; -.
DR OrthoDB; 5405601at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0022626; C:cytosolic ribosome; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0051059; F:NF-kappaB binding; IEA:Ensembl.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0085020; P:protein K6-linked ubiquitination; IEA:Ensembl.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:Ensembl.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR CDD; cd16470; RING-H2_RNF25; 1.
DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR039133; RNF25.
DR InterPro; IPR006575; RWD_dom.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13198:SF4; E3 UBIQUITIN-PROTEIN LIGASE RNF25; 1.
DR PANTHER; PTHR13198; RING FINGER PROTEIN 25; 1.
DR Pfam; PF05773; RWD; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00591; RWD; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF54495; UBC-like; 1.
DR PROSITE; PS50908; RWD; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 18..128
FT /note="RWD"
FT /evidence="ECO:0000259|PROSITE:PS50908"
FT DOMAIN 135..202
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 267..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..366
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 459 AA; 51209 MW; 45C5AA30D7295A10 CRC64;
MAASASASAG EEDWVLPSEV EVLESIYLDE LQVVKGNGRS SPWEIYITLH PATAEDQDSQ
YVCFTLVLQV PAQYPNEVPQ ISIRNPRGLS DEQIHKISQA LNHVANAGLG TAMLYELIEK
GKEILTDNNI PHGQCVICLY GFQEKEAFTK TPCYHYFHCH CLARYIQHME RELQAQGQEQ
EQERQHAATK QKTVGVQCPV CREPLVYDLA SLKAAPEPQQ PMELYQPNAE SLRQQEERRR
LYQRQQERGG IIDLEAERNR YFISLQQPPA PVEPESATDA SRGSHPPTAL ATELSTSSAA
QPHLSAPLPV ASQYTCEKIP GPGPNQQRLG ETQKAMLDPP RANRGAWKQP ERRHLKGGEC
HAHKGTSDTQ ELPPPEGPLK EPMDLKPEPC SQGVEGPPQE KGPGNWQGPP PRRTRDCARW
ERSKGRTPGS SYPRLPRGRG AYRPGTRREP LSLESEDGS
//
