ID A0A384C3P4_URSMA Unreviewed; 1009 AA.
AC A0A384C3P4;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=KN motif and ankyrin repeat domain-containing protein 4 {ECO:0000313|RefSeq:XP_008689020.1, ECO:0000313|RefSeq:XP_040483150.1};
DE SubName: Full=KN motif and ankyrin repeat domains 4 {ECO:0000313|Ensembl:ENSUMAP00000020369};
GN Name=KANK4 {ECO:0000313|Ensembl:ENSUMAP00000020369,
GN ECO:0000313|RefSeq:XP_008689020.1, ECO:0000313|RefSeq:XP_040483150.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008689020.1};
RN [1] {ECO:0000313|Ensembl:ENSUMAP00000020369}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008689020.1, ECO:0000313|RefSeq:XP_040483150.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008689020.1,
RC ECO:0000313|RefSeq:XP_040483150.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_008689020.1; XM_008690798.2.
DR RefSeq; XP_040483150.1; XM_040627216.1.
DR STRING; 29073.ENSUMAP00000020369; -.
DR Ensembl; ENSUMAT00000024130.1; ENSUMAP00000020369.1; ENSUMAG00000014917.1.
DR GeneID; 103663072; -.
DR KEGG; umr:103663072; -.
DR CTD; 163782; -.
DR OrthoDB; 123304at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl.
DR GO; GO:0030837; P:negative regulation of actin filament polymerization; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR047184; KANK1-4.
DR InterPro; IPR021939; KN_motif.
DR PANTHER; PTHR24168; KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24168:SF24; KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF12075; KN_motif; 1.
DR SMART; SM00248; ANK; 3.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 837..862
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 909..941
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 942..967
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 71..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 173..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 278..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 447..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 514..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 634..757
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 370..418
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..309
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..568
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..697
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 707..728
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1009 AA; 108487 MW; 8BFD18B730B8A4DA CRC64;
MEKTDAKDQS SQGDEEKGPP KSHPYSVETP YGFHLDLDFL KYVDDIEKGN TIRRIPIHRR
AKQAKFSTLP RNFSLPDSRA RPHTALPHQN WSPVVPRKVS LGTEERAQAL PPGELPQTST
SGSEVSYHRK ALLAETARHL EAAAPREAEL APGSGRPQLL RASSMPATLL QNRASEDSSL
NSGPPTPPAL PPLQGEGNAC DGTFGPADGF AGFQNSTPRA TTQLKVREFG DLVPGIPELV
QEGTEPPEDE DEEEALNHLS FPSPPFLSQD ALVVLEDEED EHKTREAEVV VTPGSPTPSP
PPLPSPIPEN EFPVEEIELN ISEIPPPPPV EIDVRSIGIR VTEESLGLPA MDPGSISSLK
KRLSALEGEL SGRTKELAQV RAALQQQEEE IKARGQRIQE LEHTVAQLAE KLSHENTTDT
QGQTDAMVNT DPLHGLLTRE SCDKSIEVNL PGSTGSESWR AGGEENGLLG GQVSHKPGDR
SPAELMPQLS LPQGPEMVLT PSLPSCLSTE LRIEEAGSEQ EGSPQVGAEG LGKGAGGSSW
SSDRKMPPAG REEASSELPG KERSRRPPSS PTDATLGQYV KKIQELLQEQ WSCLEHGYPE
LASAIKQPAS KLSSIQSQLL SSLNLLLSAY SAHVPPQQEP PAPSTSPPME SSPSTSLKSI
MKKKDYGFRA GGNGTKKNLQ FVGVNGGYET TSSEETSSED SSPEDLSDSE AEKKCDGPEH
RRGKEAHPAC KAGQGIPEGT STTGQESGPG EELPHPKAER YKPSEEFLNA CWALSQHLPE
TGATTDQLLR QTLNTIRQEW FRISSRKSSS PAVVAAYLRG VQSPHFLKLL VNLADGNGNT
ALHYSVSHSN FSVVKLLLET GVCNVDHQNK AGYTAVMITP LASAETDEDM AVVWKLLREG
NVNIQATQGG QTALMLGVSH DREDMVQALL SCQADVNLQD HEGSSALMLA CHHGNADMVR
LLLAHPACDS TLTDKAGRTA LSIVLKSPAH VEIAGLLRAH AEQGRSLGP
//
