ID A0A384C491_URSMA Unreviewed; 733 AA.
AC A0A384C491;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 03-AUG-2022, sequence version 2.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=E3 ubiquitin-protein ligase SH3RF2 isoform X2 {ECO:0000313|RefSeq:XP_008689662.2};
GN Name=SH3RF2 {ECO:0000313|RefSeq:XP_008689662.2};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008689662.2};
RN [1] {ECO:0000313|RefSeq:XP_008689662.2}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008689662.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SH3RF family.
CC {ECO:0000256|ARBA:ARBA00008649}.
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DR RefSeq; XP_008689662.2; XM_008691440.2.
DR AlphaFoldDB; A0A384C491; -.
DR STRING; 29073.ENSUMAP00000014399; -.
DR OrthoDB; 5407056at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008157; F:protein phosphatase 1 binding; IEA:Ensembl.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0031397; P:negative regulation of protein ubiquitination; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0051865; P:protein autoubiquitination; IEA:Ensembl.
DR CDD; cd16749; RING-HC_SH3RF2; 1.
DR CDD; cd11929; SH3_SH3RF2_1; 1.
DR CDD; cd11932; SH3_SH3RF2_2; 1.
DR CDD; cd11784; SH3_SH3RF2_3; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 3.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR028511; SH3RF2_RING-HC_Zfn.
DR InterPro; IPR035792; SH3RF2_SH3_1.
DR InterPro; IPR035794; SH3RF2_SH3_2.
DR InterPro; IPR035822; SH3RF2_SH3_3.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR14167:SF60; E3 UBIQUITIN-PROTEIN LIGASE SH3RF2; 1.
DR PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF14604; SH3_9; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00184; RING; 1.
DR SMART; SM00326; SH3; 3.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF50044; SH3-domain; 3.
DR PROSITE; PS50002; SH3; 3.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
SQ SEQUENCE 733 AA; 79614 MW; 116F87B674701BFE CRC64;
MDDLTLLDLL ECPVCFEKLD VTAKVLPCQH TFCKPCLQRI FKAHKELRCP ECRTLVFCSI
EALPANLLLV RLLDGVRSGQ SSGRGGSFRR PGVLTPQDSR KSRTNPRGLQ SSPFRLVPNI
RIHMDGVPRA KALCNYRGQN PGDLKFNKGD VILLRRQLDE NWYQGEINGV SGIFPASSVE
VIKQLPQPPP LCRALYNFDL RDKDKSENQD CLTFLKDDII TVISRVDENW AEGKLGDQVG
IFPILFVEPN LTARHLLEKH RGRQSAHTKS LSLVPSASRG KAAHTPTLRR GPGSRRKGPG
QFSITTALNT LNRMVHSPSG RQTVDISTPV LISSSNPSVI TQHVEKADVP PISMGQVSTY
HPVPASPGHS TAIVSLPGSQ QHLSANMFVA LHSYSAHGPD ELDLQKGEGI RVLGKYPDGW
LRGVSLVTGR VGIFPNNYVI PIFRKTSSFP DSRSPGLYAT WTLSNSSVSS QGSISEGDPR
QNRPFKSVFV PTAIVNPVKS TASPGTVGQG SLRKSGRSSM RKNGSLQRPV PSGIPALVVG
SLRRNPTMVV RPQQFQFYQP QGVPSSPPTV VSELGPKPTP TGEPALTCVS RGSDTRIRSA
ASSLIMEGKE IPIKSEPLPK PPASAPPSIL VKPENSRNGV EKQVKTVRFQ NYSPPPAKQY
TSHPTSGKPE QPTTPKGSQP EATPSSPEMT VLFAHRSGCH SGQQTDLRRK SSLGKTMTPV
STASATQTVF PSK
//