ID   A0A384C491_URSMA        Unreviewed;       733 AA.
AC   A0A384C491;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   03-AUG-2022, sequence version 2.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=E3 ubiquitin-protein ligase SH3RF2 isoform X2 {ECO:0000313|RefSeq:XP_008689662.2};
GN   Name=SH3RF2 {ECO:0000313|RefSeq:XP_008689662.2};
OS   Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008689662.2};
RN   [1] {ECO:0000313|RefSeq:XP_008689662.2}
RP   IDENTIFICATION.
RC   TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008689662.2};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the SH3RF family.
CC       {ECO:0000256|ARBA:ARBA00008649}.
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DR   RefSeq; XP_008689662.2; XM_008691440.2.
DR   AlphaFoldDB; A0A384C491; -.
DR   STRING; 29073.ENSUMAP00000014399; -.
DR   OrthoDB; 5407056at2759; -.
DR   Proteomes; UP000261680; Unplaced.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008157; F:protein phosphatase 1 binding; IEA:Ensembl.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR   GO; GO:0031397; P:negative regulation of protein ubiquitination; IEA:Ensembl.
DR   GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR   GO; GO:0051865; P:protein autoubiquitination; IEA:Ensembl.
DR   CDD; cd16749; RING-HC_SH3RF2; 1.
DR   CDD; cd11929; SH3_SH3RF2_1; 1.
DR   CDD; cd11932; SH3_SH3RF2_2; 1.
DR   CDD; cd11784; SH3_SH3RF2_3; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 3.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR028511; SH3RF2_RING-HC_Zfn.
DR   InterPro; IPR035792; SH3RF2_SH3_1.
DR   InterPro; IPR035794; SH3RF2_SH3_2.
DR   InterPro; IPR035822; SH3RF2_SH3_3.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   PANTHER; PTHR14167:SF60; E3 UBIQUITIN-PROTEIN LIGASE SH3RF2; 1.
DR   PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   Pfam; PF07653; SH3_2; 1.
DR   Pfam; PF14604; SH3_9; 1.
DR   Pfam; PF13639; zf-RING_2; 1.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00184; RING; 1.
DR   SMART; SM00326; SH3; 3.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   SUPFAM; SSF50044; SH3-domain; 3.
DR   PROSITE; PS50002; SH3; 3.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
SQ   SEQUENCE   733 AA;  79614 MW;  116F87B674701BFE CRC64;
     MDDLTLLDLL ECPVCFEKLD VTAKVLPCQH TFCKPCLQRI FKAHKELRCP ECRTLVFCSI
     EALPANLLLV RLLDGVRSGQ SSGRGGSFRR PGVLTPQDSR KSRTNPRGLQ SSPFRLVPNI
     RIHMDGVPRA KALCNYRGQN PGDLKFNKGD VILLRRQLDE NWYQGEINGV SGIFPASSVE
     VIKQLPQPPP LCRALYNFDL RDKDKSENQD CLTFLKDDII TVISRVDENW AEGKLGDQVG
     IFPILFVEPN LTARHLLEKH RGRQSAHTKS LSLVPSASRG KAAHTPTLRR GPGSRRKGPG
     QFSITTALNT LNRMVHSPSG RQTVDISTPV LISSSNPSVI TQHVEKADVP PISMGQVSTY
     HPVPASPGHS TAIVSLPGSQ QHLSANMFVA LHSYSAHGPD ELDLQKGEGI RVLGKYPDGW
     LRGVSLVTGR VGIFPNNYVI PIFRKTSSFP DSRSPGLYAT WTLSNSSVSS QGSISEGDPR
     QNRPFKSVFV PTAIVNPVKS TASPGTVGQG SLRKSGRSSM RKNGSLQRPV PSGIPALVVG
     SLRRNPTMVV RPQQFQFYQP QGVPSSPPTV VSELGPKPTP TGEPALTCVS RGSDTRIRSA
     ASSLIMEGKE IPIKSEPLPK PPASAPPSIL VKPENSRNGV EKQVKTVRFQ NYSPPPAKQY
     TSHPTSGKPE QPTTPKGSQP EATPSSPEMT VLFAHRSGCH SGQQTDLRRK SSLGKTMTPV
     STASATQTVF PSK
//