ID   A0A384C508_URSMA        Unreviewed;       833 AA.
AC   A0A384C508;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   03-AUG-2022, sequence version 2.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Protocadherin alpha-10-like {ECO:0000313|RefSeq:XP_008689933.2};
GN   Name=LOC103663930 {ECO:0000313|RefSeq:XP_008689933.2};
OS   Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008689933.2};
RN   [1] {ECO:0000313|RefSeq:XP_008689933.2}
RP   IDENTIFICATION.
RC   TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008689933.2};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_008689933.2; XM_008691711.2.
DR   KEGG; umr:103663930; -.
DR   OrthoDB; 5402790at2759; -.
DR   Proteomes; UP000261680; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   CDD; cd11304; Cadherin_repeat; 6.
DR   Gene3D; 2.60.40.60; Cadherins; 6.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR013164; Cadherin_N.
DR   PANTHER; PTHR24028; CADHERIN-87A; 1.
DR   PANTHER; PTHR24028:SF124; PROTOCADHERIN ALPHA-10; 1.
DR   Pfam; PF00028; Cadherin; 4.
DR   Pfam; PF08266; Cadherin_2; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 6.
DR   SUPFAM; SSF49313; Cadherin-like; 6.
DR   PROSITE; PS00232; CADHERIN_1; 3.
DR   PROSITE; PS50268; CADHERIN_2; 6.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           29..833
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5035478982"
FT   TRANSMEM        699..722
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        800..820
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          34..133
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          134..242
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          243..350
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          351..455
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          456..565
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          582..679
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
SQ   SEQUENCE   833 AA;  89770 MW;  97E8AB87B9C17F4F CRC64;
     MLVYTPSGPR ALRLLLLLLL LAAWKAGSRQ VHYSVPEEAK HGTFVGRIAQ DLGLELAELV
     PRLFRVVSKG HGDLLEVNLQ NGILFVNSRI DREALCGRSL ECSIHLEVIV DRPLQVFHVE
     VEVKDINDNP PVFSVSEQKL SIPESRLLDS RFPLEGASDA DVGENAALTY RLSPNEFFVL
     DVINKKDKGK FPVLVLGKML DREENPQLQL LLTATDGGKP EYTGSVTLLI LVLDANDNAP
     IFDRSIYEVK MYENSANQTL VIWLNASDAD EGINKEMIYS FSALVPPNVR RTFLMNEKTG
     EIRVNDAIDF EDSNTYEIHV DVTDKGNPPM VGHCTILVEV LDENDNSPDV VITSLALPVL
     EDAPVGTVIA LISVSDRDSG ANGQVTCTLA PHSPFKLVST FKNYYSLVLE SALDRESVAN
     YVLVVTARDG GSPSLSATAS VSVEVADVND NAPAFAQPEY TVFVRENNPP GCHIFTVSAR
     DADAQENALV SYSLVERRVG ERALSSYVSV HAESGKVYAL QPLDHEELEL LQFQVSARDA
     GVPPLGSNVT LQVFVLDEND NAPALLPRPG AGGAGGALSE LVSRSVGAGH VVAKVRAVDA
     DSGYNAWLSY ELQPAAGGAR SPFRVALYTG EISTTRTLDE ADSARQRLLV LVKDHGEPAL
     TATATVLLSL VESGQAPKAS SRVLAGAAGA EAALVDVNVY LIVAICAVSS LLVLTLLLYT
     ALRCSAPPTQ GACGPGKPTL VCSSAVGSWS YSQQRRQRVC SGEGPPKTDL MAFSPSLPPC
     PVPDVEVEEQ SIGGDCSRKV GYYFFISICC FVNNILSTAF PPHIYVSEYL HPF
//