ID A0A384C546_URSMA Unreviewed; 654 AA.
AC A0A384C546;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 03-AUG-2022, sequence version 2.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Zinc finger protein 630 {ECO:0000313|RefSeq:XP_008689968.2};
GN Name=ZNF630 {ECO:0000313|RefSeq:XP_008689968.2};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008689968.2};
RN [1] {ECO:0000313|RefSeq:XP_008689968.2}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008689968.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_008689968.2; XM_008691746.2.
DR AlphaFoldDB; A0A384C546; -.
DR KEGG; umr:103663934; -.
DR OrthoDB; 5259849at2759; -.
DR Proteomes; UP000261680; Chromosome X.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 14.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24408; ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR24408:SF34; ZINC FINGER PROTEIN 672; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 12.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 8.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 8..79
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 260..287
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 288..315
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 316..343
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 344..371
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 372..399
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 400..427
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 428..455
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 456..483
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 484..511
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 512..539
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 540..567
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 568..595
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
SQ SEQUENCE 654 AA; 74897 MW; 5D18A7ADCDB68DCE CRC64;
MTESQELVTY EDVAVDFTQE EWQHLDPAQK TLHRDVMLET YSHLVSVGCS GIKPGIIFKL
EREEDPRIIK SELSTWVHSD REKSLDSPQQ IISEELSFQK EILEKAPKGN SWYSLLKVWH
VDGQIDRYQG NQDRLLKQVT VISHETLAKE KGPKCNTFGK IFGGCTDLDP SSKKLCDFDS
YEKSLKYDLD SLTCSRSYAR KNPIEKFGCG TPPSYSDSFS VPEKIYTGMK PCGCSRCEKG
LNHKQVCVQY KKDQAGKKPN VCSECGKSFI KKSQLIIHQR IHTGEKPYVC GDCGKAFSEK
SHLIVHQRIH TGEKPYECTE CGRAFSQKSP FIVHQRVHTG EKPYECFECQ KAFSQKSHLI
IHQRVHAREK PFECSECGKA FCEKSHLFIH QVTHTGERPY KCTECEKTFP RKTQLIIHRR
THTGEKPYRC SECGKTFCQQ SHLIGHQRIH TGEKPYICTN CGKAFSQKSH LTGHQRLHTG
EKPYTCTECG KAFSQKSPLI IHQRIHTGEK PYECSDCGKT FSQKSPLIIH QRIHTGEKPY
ECTECGRAFS LKSHLIIHQR AHAGQKPYEC SECGKTFCEK SPLAVHQKTH TREKPSEAAE
YGMAFSWKSQ MITYQRTHAG EKPSKCSDCG KVFCQHICLT GHENPRRRET SYMY
//
