ID   A0A384C5Q9_URSMA        Unreviewed;       808 AA.
AC   A0A384C5Q9;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   03-AUG-2022, sequence version 2.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Protocadherin alpha-10-like {ECO:0000313|RefSeq:XP_008689720.2};
GN   Name=LOC103663741 {ECO:0000313|RefSeq:XP_008689720.2};
OS   Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008689720.2};
RN   [1] {ECO:0000313|RefSeq:XP_008689720.2}
RP   IDENTIFICATION.
RC   TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008689720.2};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_008689720.2; XM_008691498.2.
DR   KEGG; umr:103663741; -.
DR   OrthoDB; 5402790at2759; -.
DR   Proteomes; UP000261680; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   CDD; cd11304; Cadherin_repeat; 6.
DR   Gene3D; 2.60.40.60; Cadherins; 6.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR013164; Cadherin_N.
DR   PANTHER; PTHR24028; CADHERIN-87A; 1.
DR   PANTHER; PTHR24028:SF133; PROTOCADHERIN ALPHA-9; 1.
DR   Pfam; PF00028; Cadherin; 5.
DR   Pfam; PF08266; Cadherin_2; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 6.
DR   SUPFAM; SSF49313; Cadherin-like; 6.
DR   PROSITE; PS00232; CADHERIN_1; 3.
DR   PROSITE; PS50268; CADHERIN_2; 6.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           29..808
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5035462044"
FT   TRANSMEM        699..719
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          27..133
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          134..242
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          243..350
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          351..455
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          456..565
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          582..679
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
SQ   SEQUENCE   808 AA;  86270 MW;  5DC34D4329E2889F CRC64;
     MLASGPGGQG TKHLLLSVLF LAVWEAESGQ VHYSVPEEAK HGTFVGRIAQ DLGLELTELV
     PRLFRVASKG HEDLLEVNLQ NGILFVNSRI DREELCVRSA ECSIHLEVIV DRPLQVFHVE
     VEVKDINDNP PVFPAAQKNL FVSETRALDS HFSLEGASDA DIGANALLTY RLSPNEYFSL
     LVPTNDDQVK PLQLVLKKPL DREVASELLL VLQATDGGKP ELTGSTELHI TVLDVNDNAP
     VFDKAVYRVK LLENSRNGTL VIRLNASDLD EGSNSHILYS FAADVSSNPE AFFRIDSASG
     EIKVNGKIDF EETKLWKLQI EAVDKGNPPM FGHCTVLIEI LDINDDAPEL LVTSLSLSVP
     EDATLGTVIA LIRVSDRDSG ANGQVTCSLI PHVPFKLVST FKNYYSLVLE SALDRESVAN
     YVLIVTARDG GSPSLSTTAS MSVEVADVND NAPAFAQPEY TVFVRENNPP GCHIFTVSAR
     DADAQENALV SYSLVERRVG ERALSSYVSV HAESGKVYAL QPLDHEELEL LQFQVSARDA
     GVPPLGSNVT LQVFVLDEND NAPALLPRPG AGGAGGALSE LVSRSVGAGH VVAKVRAVDA
     DSGYNAWLSY ELQPAAGGAR SPFRVALYTG EISTTRTLDE ADSARQRLLV LVKDHGEPAL
     TATATVLLSL VESGQAPKAS SRVLAGAAGA EAALVDVNVY LIVAICAVSS LLVLTLLLYT
     ALRCSAPPTE GACGPGKPTL VCSSAVGSWS YSQQRRQRVC SGEGPPKTDL MAFSPCVPPG
     SSSGDSGEQQ GIFGNDVSTV ILNVFNAC
//