ID A0A384C6K7_URSMA Unreviewed; 447 AA.
AC A0A384C6K7;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 03-AUG-2022, sequence version 2.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Docking protein 3 {ECO:0000313|RefSeq:XP_008690531.2};
GN Name=DOK3 {ECO:0000313|RefSeq:XP_008690531.2};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008690531.2};
RN [1] {ECO:0000313|RefSeq:XP_008690531.2}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008690531.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOK family. Type A subfamily.
CC {ECO:0000256|ARBA:ARBA00010955}.
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DR RefSeq; XP_008690531.2; XM_008692309.2.
DR AlphaFoldDB; A0A384C6K7; -.
DR STRING; 29073.ENSUMAP00000033709; -.
DR KEGG; umr:103664438; -.
DR OrthoDB; 2996885at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR CDD; cd14676; PH_DOK1_2_3; 1.
DR CDD; cd01203; PTB_DOK1_DOK2_DOK3; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR037751; Dok1/2/3_PTB.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR21258:SF42; DOCKING PROTEIN 3; 1.
DR PANTHER; PTHR21258; DOCKING PROTEIN RELATED; 1.
DR Pfam; PF02174; IRS; 1.
DR SMART; SM01244; IRS; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00310; PTBI; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS51064; IRS_PTB; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000261680}.
FT DOMAIN 157..261
FT /note="IRS-type PTB"
FT /evidence="ECO:0000259|PROSITE:PS51064"
FT REGION 260..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 356..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..447
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 447 AA; 48792 MW; DF3818A0772ACD61 CRC64;
MEPLETPIKD GILYQQHVKF GKKSWRKVWG LLYAGSPSGV ARLESWEVRD GGLGPAGDRS
AGPSRRGERR VIRLADCVSV LPADGESCPK DTGAFLLTTT ERSHLLAAQH RQEWMGPICQ
LAFQGTGECS SGPGEVEASK RGLVPMEENS IYSSWQEVGE FPVVVQRTEA ATRCQLKGPY
LLVLGQDTIH LREPSSPQAL YTWPYRFLRK FGSDKDVFSF EAGRRCDSGE GLFAFSSPRA
LDLCRAVAAA IARQRERLPE LAGPRPCPLP RATSLPSLDP PGELREVPPG LETPSSWRAR
LAEPGPQSLP PLLSPVPHDE PVSGLYASVC KRASGPPSNA EHLYENLCVL EAGPVLPRDR
DPEQEGPSRR SPLASPIYHN SEDLGWPGPA HDSSLEAQYR RLLELELGDS DEAGGSGRPS
AHTGFKAKLV TLLSRERKKG PAPCDRH
//
