ID A0A384C714_URSMA Unreviewed; 1509 AA.
AC A0A384C714;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 03-AUG-2022, sequence version 2.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Gem-associated protein 5 isoform X1 {ECO:0000313|RefSeq:XP_008690681.2};
GN Name=GEMIN5 {ECO:0000313|RefSeq:XP_008690681.2};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008690681.2};
RN [1] {ECO:0000313|RefSeq:XP_008690681.2}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008690681.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_008690681.2; XM_008692459.2.
DR KEGG; umr:103664554; -.
DR OrthoDB; 2954862at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR46362; GEM-ASSOCIATED PROTEIN 5; 1.
DR PANTHER; PTHR46362:SF1; GEM-ASSOCIATED PROTEIN 5; 1.
DR Pfam; PF12894; ANAPC4_WD40; 3.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 13.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 60..104
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 117..204
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 241..264
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 394..479
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT DOMAIN 540..588
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 635..668
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 717..799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1312..1343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1389..1433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 721..735
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..769
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1312..1327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1328..1343
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1389..1424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1509 AA; 168448 MW; C37FB4BD8455C641 CRC64;
MGQEPRTLPP SPNWYCARCS DAVPGGLFGF AARTSVFLVR VGPSAGAIPG TPPFRVIGEL
VGHTERVSGF TFSHHPGQYH LCATSSDDGT VKIWDVETKT VVTEHALHQH TISALHWSPQ
VKDLIVSGDE KGVVFCYWLN RNDSQHLFIE PRTIFCLTCS PHHEDLVAIG YKDGIVVIID
ISKKGEVIHR LRGHDDEIHS IAWCPLPGED CLSINQEENS EEPEIPNGKV IAQTPVTKGC
YLATGSKDQT IRIWSCSRGR GVMILKLPFL KRRGGGIDPT IKERLWLTLH WPKDQPTQLV
SSCFGGELLL WDLTQSWRRK YTLFSASSEG QNHSRIVFNL CPLQTEDDKQ LLLSTSMDRD
VKCWDMATLE CCWTLPSLGG FAYSLAFSPV DMGCLAIGVG DGMIRVWNTL SIKNNYDVKN
FWQGVKSKVT ALCWHPTKEG CLAFGTDDGK VGLYDTYSNK PPQISSTYHK KTVYTLAWGP
PLPPISLGGE GDRPSLTLYS CGGEGVVLQH NPWKLGGEAY DINKLIRDTN SIKYKLPVHT
EISWKADGKI MALGNEDGSI EIFQVPNLKL ICTIQQHHKL VNTISWHHEH GSQPELSYLM
ASGSNNAVIY VHNLKTVIES NPESPVTVTE PYRTLSGHTA KITSVAWSPH HDGRLVSASY
DGTAQVWDTL REEPLCNFRG HRGRLLCVAW SPLDPDCIYS GADDFCVYKW LTSMQEHSRP
PQGKKSIELE KKRLSQPKPK PKKKKKPTSR APIKQEVYDG NEDESIRESS GPVENGVSDQ
EGEEEAREPE FPSGVASVAS REPVTCAPVL LGFEKSKVTV NNKVTLLKKE PPKEKPESLT
KKRKARSMLP LTTSLDHRSK EELHQDCLVL ATAKHSKAEL NEEVSTDLEE RFHLGLFTDR
AALYRMIEVE GKGHLENGHP ELFHQLMLWK GDLKGVLQTA AERGELTDSL VAMAPVAGYH
VWLWAVEAFA KQLCFQDQYV KAASHLLSIH KVYEAVELLK SNHFYREAIA VAKARLRPED
PILKDLYLTW GAILEKDGHY AVAAKCYLGA ASAYDAAKVL AKKGDAASLK TAAELASIVG
ENELSSSLAL RCAQELLLAR NWVGAQEALK LHESLKGQRL VFCLLELLSK HLEERQLSEA
KSSSYNAWAA GTDGPFVERV TAVWKSIFSL DTPEQYQAAL QQLQSIKYPS ATNNTPSKQL
LLHICHDLTL AVLSQQVASW DAAVEALLRA VVRSYDSGNF TIMQEVHSAF LPEGCDHLRD
KLGEHQSPTT PAFKSLEAFF IYGHLYEFWW SLSRPCPKSS VWVRAAHRRT TSLEQSQQIN
NASTKETDPK VSEPEPSRPP ELDVRLTEQS EQMLITCKEL FSEKHASLQN SQRTVAEVQE
TLAEMIRQHQ KSQVCKSSTN GPDKNESEQV AEQSLSSPPS ECKEEKNQPL SLPELTKRLT
EANEKIAKFP ESVKTWPFPD VLECCLILLH IGSQCPGSVT QDMQQQAQEL LQKYGNTKVY
KRYCQTFCT
//
