UniProt: A0A384C7B1

Database: UniProt
Entry: A0A384C7B1_URSMA

LinkDB:  A0A384C7B1_URSMA 
Original site:  A0A384C7B1_URSMA

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Ontology (5)   
   GO (5)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (19)   
   InterPro (10)   
   Pfam (4)   
   PROSITE (3)   
   SMART (2)   
All databases (27)   

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ID   A0A384C7B1_URSMA        Unreviewed;      1179 AA.
AC   A0A384C7B1;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Integrin alpha-2 {ECO:0000313|RefSeq:XP_008690776.1};
GN   Name=ITGA2 {ECO:0000313|RefSeq:XP_008690776.1};
OS   Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008690776.1};
RN   [1] {ECO:0000313|RefSeq:XP_008690776.1}
RP   IDENTIFICATION.
RC   TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008690776.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC       ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC   -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC       {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR   RefSeq; XP_008690776.1; XM_008692554.2.
DR   AlphaFoldDB; A0A384C7B1; -.
DR   STRING; 29073.ENSUMAP00000007497; -.
DR   GeneID; 103664633; -.
DR   KEGG; umr:103664633; -.
DR   CTD; 3673; -.
DR   OrthoDB; 3816176at2759; -.
DR   Proteomes; UP000261680; Unplaced.
DR   GO; GO:0009986; C:cell surface; IEA:UniProt.
DR   GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR   Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR   Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR   Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR   Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR013517; FG-GAP.
DR   InterPro; IPR013519; Int_alpha_beta-p.
DR   InterPro; IPR000413; Integrin_alpha.
DR   InterPro; IPR018184; Integrin_alpha_C_CS.
DR   InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR   InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR   InterPro; IPR028994; Integrin_alpha_N.
DR   InterPro; IPR032695; Integrin_dom_sf.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR   PANTHER; PTHR23220:SF23; INTEGRIN ALPHA-2; 1.
DR   Pfam; PF01839; FG-GAP; 2.
DR   Pfam; PF20805; Integrin_A_Ig_2; 1.
DR   Pfam; PF20806; Integrin_A_Ig_3; 1.
DR   Pfam; PF00092; VWA; 1.
DR   PRINTS; PR01185; INTEGRINA.
DR   PRINTS; PR00453; VWFADOMAIN.
DR   SMART; SM00191; Int_alpha; 5.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR   SUPFAM; SSF69179; Integrin domains; 3.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS51470; FG_GAP; 6.
DR   PROSITE; PS00242; INTEGRIN_ALPHA; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW   ECO:0000256|RuleBase:RU003762};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003762};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU003762}.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000256|RuleBase:RU003762"
FT   CHAIN           28..1179
FT                   /evidence="ECO:0000256|RuleBase:RU003762"
FT                   /id="PRO_5016478534"
FT   TRANSMEM        1132..1156
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003762"
FT   REPEAT          32..90
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   DOMAIN          172..359
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REPEAT          364..418
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          421..473
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          475..537
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          538..596
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          600..662
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ   SEQUENCE   1179 AA;  129088 MW;  25EBC095EA4E70C3 CRC64;
     MRPGRAGGAP LRLVLVLSQG LLNCCMAYNV GLLEAKIFSG PSSEQFGYAV QQFINPKGNW
     LLVGSPWSGF PANRMGDVYK CPVDLSTATC EKLNLETATS IPNVTEMKTN MSLGLTLTRN
     MGTGGFLTCG PLWAQQCGSQ YYTTGVCSDV SADFQLLTSF APAVQACPAL IDVVVVCDES
     NSIYPWEAVK NFLEKFVQGL DIGPKKTQVG LIQYANKPRV VFNLNTFKTK AEMIEATSQT
     YQYGGDLTNT FKAIQYAKDF AYAAGAGGRP GATKVMVVVT DGESHDGSML KAVIDQCNND
     NILRFGIAVL GYLNRNALDT KNLIKEIKAI ASIPTERYFF NVSDEAALLE KAGTLGEQIF
     SIEGTTQGGD NFQMEMSQVG FSADYSPQND ILMLGAVGAY AWSGTVVQQT SHGHLIFPNQ
     AFDQILQDKN HSSYLGYSVA AISTGTDIHF VAGAPRANYT GQIVLYSVNE NGNVTVIQAH
     RGDQIGSYFG SVLCSVDVNK DTITDVLLVG APTYMNDLKK EEGRVYLFTI TRGVLNWHQF
     LEGPEGVENA RFGSAIAALS DINMDGFNDV IVGSPLENQN SGAVYIYNGH EGTIRKRYSQ
     KILGSDGAFR SQLQYFGRSL DGYGDLNGDS ITDVSVGAFG QVVQLWSQSI ADVSVDASFT
     PEKITLFNKN ADIKLTLCFS AKFRPTKQND QVAILYNITI DADLYSSRVT SRGLFKDNNE
     RCLQRNMLVS QAQSCAEYDI HIQKPSDVVS SLDLCVNISL ENPGASPALE AYSEKAKVFS
     IPFYKDCGDD GVCISDLVLD VQQLSAAQDQ AFIVGNQNRR LTFSITLKNK RESAYNTEIV
     VGFSENLFFA SWSMPVDGTE VTCQIASSQR TVTCDVGYPA LKREQQVTFT INFDFNLQSL
     QNQASVSFQA SSESHEENEA DNSVSFKIPL RYDADIHITR FTNINFYEVS SDGNVPSIVH
     SFEDIGPKFT FSIKVTTGSV PVSMASVIIH IPQYTKDKNP LMYLTGVHTD QAGDISCNAE
     INPLKIGHTS PSVSFKNENF RHIKELNCRT ASCGNVTCWL KDLQVKGEYF LNVSTRIWNG
     TFAASTFQTI QLTASAEIDT YNPQIYVIEE NTVTIPITIM KPHEKAEVPT GVIVGSVIAG
     ILLLLALVAV LWKLGFFKRK YEKMSKNADE IDETTELNS
//

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