GenomeNet

Database: UniProt
Entry: A0A384C8D7_URSMA
LinkDB: A0A384C8D7_URSMA
Original site: A0A384C8D7_URSMA 
ID   A0A384C8D7_URSMA        Unreviewed;       510 AA.
AC   A0A384C8D7;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   RecName: Full=Transcription factor 4 {ECO:0000256|ARBA:ARBA00040305};
GN   Name=TCF4 {ECO:0000313|RefSeq:XP_008690650.1};
OS   Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008690650.1};
RN   [1] {ECO:0000313|RefSeq:XP_008690650.1}
RP   IDENTIFICATION.
RC   TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008690650.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_008690650.1; XM_008692428.2.
DR   AlphaFoldDB; A0A384C8D7; -.
DR   GeneID; 103664490; -.
DR   CTD; 6925; -.
DR   OrthoDB; 2915397at2759; -.
DR   Proteomes; UP000261680; Unplaced.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   CDD; cd18945; bHLH_E-protein_TCF4_E2-2; 1.
DR   Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   PANTHER; PTHR11793; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR; 1.
DR   PANTHER; PTHR11793:SF10; TRANSCRIPTION FACTOR 4; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          407..460
FT                   /note="BHLH"
FT                   /evidence="ECO:0000259|PROSITE:PS50888"
FT   REGION          60..85
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          105..161
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          176..218
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          308..413
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          477..510
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        107..159
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        308..327
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        352..413
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   510 AA;  54435 MW;  31C70BE6A2C5087F CRC64;
     MYCAYTIPGM GGNSLMYYYN GKAVYAPSAS TADYNRDSPG YPSSKPAAST FPSSFFMQDG
     HHSSDPWSSS SGMNQPGYGG MLGSSSHIPQ SSSYCSLHPH ERLSYPSHSS ADINSSLPPM
     STFHRSGTNH YSTSSCTPPA NGTDSIMANR GSGAAGSSQT GDALGKALAS IYSPDHTNNS
     FSSNPSTPVG SPPSLSGTAV WSRNGGQASS SPNYEGPLHS LQSRIEDRLE RLDDAIHVLR
     NHAVGPSTAM PGGHGDMHGI IGPSHNGAMG GLGSGYGTGL LSANRHSLMV GAHREDGVAL
     RGSHSLVPNQ VPVPQLPVQS ATSPDLNPPQ DPYRGMPPGL QGQSVSSGSS EIKSDDEGDE
     NLQDTKSSED KKLDDDKKDI KSITRSRSSN NDDEDLTPEQ KAEREKERRM ANNARERLRV
     RDINEAFKEL GRMVQLHLKS DKPQTKLLIL HQAVAVILSL EQQVRERNLN PKAACLKRRE
     EEKVSSEPPP LSLAGPHPGM GDASNHMGQM
//
DBGET integrated database retrieval system