ID A0A384C8D7_URSMA Unreviewed; 510 AA.
AC A0A384C8D7;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=Transcription factor 4 {ECO:0000256|ARBA:ARBA00040305};
GN Name=TCF4 {ECO:0000313|RefSeq:XP_008690650.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008690650.1};
RN [1] {ECO:0000313|RefSeq:XP_008690650.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008690650.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_008690650.1; XM_008692428.2.
DR AlphaFoldDB; A0A384C8D7; -.
DR GeneID; 103664490; -.
DR CTD; 6925; -.
DR OrthoDB; 2915397at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd18945; bHLH_E-protein_TCF4_E2-2; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR PANTHER; PTHR11793; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR; 1.
DR PANTHER; PTHR11793:SF10; TRANSCRIPTION FACTOR 4; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 407..460
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 60..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 105..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 176..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 308..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 477..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..413
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 510 AA; 54435 MW; 31C70BE6A2C5087F CRC64;
MYCAYTIPGM GGNSLMYYYN GKAVYAPSAS TADYNRDSPG YPSSKPAAST FPSSFFMQDG
HHSSDPWSSS SGMNQPGYGG MLGSSSHIPQ SSSYCSLHPH ERLSYPSHSS ADINSSLPPM
STFHRSGTNH YSTSSCTPPA NGTDSIMANR GSGAAGSSQT GDALGKALAS IYSPDHTNNS
FSSNPSTPVG SPPSLSGTAV WSRNGGQASS SPNYEGPLHS LQSRIEDRLE RLDDAIHVLR
NHAVGPSTAM PGGHGDMHGI IGPSHNGAMG GLGSGYGTGL LSANRHSLMV GAHREDGVAL
RGSHSLVPNQ VPVPQLPVQS ATSPDLNPPQ DPYRGMPPGL QGQSVSSGSS EIKSDDEGDE
NLQDTKSSED KKLDDDKKDI KSITRSRSSN NDDEDLTPEQ KAEREKERRM ANNARERLRV
RDINEAFKEL GRMVQLHLKS DKPQTKLLIL HQAVAVILSL EQQVRERNLN PKAACLKRRE
EEKVSSEPPP LSLAGPHPGM GDASNHMGQM
//