ID A0A384C9G8_URSMA Unreviewed; 110 AA.
AC A0A384C9G8;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=C-X-C motif chemokine 13 {ECO:0000313|RefSeq:XP_008691483.1};
DE SubName: Full=C-X-C motif chemokine ligand 13 {ECO:0000313|Ensembl:ENSUMAP00000010554};
GN Name=CXCL13 {ECO:0000313|Ensembl:ENSUMAP00000010554,
GN ECO:0000313|RefSeq:XP_008691483.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008691483.1};
RN [1] {ECO:0000313|Ensembl:ENSUMAP00000010554}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008691483.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008691483.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC {ECO:0000256|ARBA:ARBA00010665}.
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DR RefSeq; XP_008691483.1; XM_008693261.2.
DR STRING; 29073.ENSUMAP00000010554; -.
DR Ensembl; ENSUMAT00000012593.1; ENSUMAP00000010554.1; ENSUMAG00000007951.1.
DR GeneID; 103665338; -.
DR KEGG; umr:103665338; -.
DR CTD; 10563; -.
DR OMA; KTIVCVN; -.
DR OrthoDB; 5358490at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0031735; F:CCR10 chemokine receptor binding; IEA:Ensembl.
DR GO; GO:0008009; F:chemokine activity; IEA:Ensembl.
DR GO; GO:0048248; F:CXCR3 chemokine receptor binding; IEA:Ensembl.
DR GO; GO:0031724; F:CXCR5 chemokine receptor binding; IEA:Ensembl.
DR GO; GO:0017134; F:fibroblast growth factor binding; IEA:Ensembl.
DR GO; GO:0008201; F:heparin binding; IEA:Ensembl.
DR GO; GO:0035754; P:B cell chemotaxis; IEA:Ensembl.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0007267; P:cell-cell signaling; IEA:Ensembl.
DR GO; GO:0042742; P:defense response to bacterium; IEA:Ensembl.
DR GO; GO:0035768; P:endothelial cell chemotaxis to fibroblast growth factor; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:2000545; P:negative regulation of endothelial cell chemotaxis to fibroblast growth factor; IEA:Ensembl.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR GO; GO:0010820; P:positive regulation of T cell chemotaxis; IEA:Ensembl.
DR CDD; cd00273; Chemokine_CXC; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR001089; Chemokine_CXC.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR033899; CXC_Chemokine_domain.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015:SF193; C-X-C MOTIF CHEMOKINE 13; 1.
DR PANTHER; PTHR12015; SMALL INDUCIBLE CYTOKINE A; 1.
DR Pfam; PF00048; IL8; 1.
DR PRINTS; PR00436; INTERLEUKIN8.
DR PRINTS; PR00437; SMALLCYTKCXC.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; Interleukin 8-like chemokines; 1.
PE 3: Inferred from homology;
KW Chemotaxis {ECO:0000256|ARBA:ARBA00022500};
KW Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..110
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041125505"
FT DOMAIN 30..91
FT /note="Chemokine interleukin-8-like"
FT /evidence="ECO:0000259|SMART:SM00199"
SQ SEQUENCE 110 AA; 12472 MW; 6D65576AA610DB05 CRC64;
MRFTLGSLLL ILLVCSLPPV HGVLEAYNTN LKCKCIQEAS VIIPMHHIDK LQVFPPGNGC
PNKEIIIWKK NKSVVCLNPH FKWTQKLVKI LQRKNAPSTR PAPVVKKRIK
//
