ID A0A384C9H7_URSMA Unreviewed; 488 AA.
AC A0A384C9H7;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 03-AUG-2022, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Anthrax toxin receptor {ECO:0000256|PIRNR:PIRNR038023};
GN Name=ANTXR2 {ECO:0000313|RefSeq:XP_008691493.2};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008691493.2};
RN [1] {ECO:0000313|RefSeq:XP_008691493.2}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008691493.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the ATR family. {ECO:0000256|ARBA:ARBA00008095,
CC ECO:0000256|PIRNR:PIRNR038023}.
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DR RefSeq; XP_008691493.2; XM_008693271.2.
DR STRING; 29073.ENSUMAP00000011355; -.
DR KEGG; umr:103665347; -.
DR OrthoDB; 5397560at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR CDD; cd01474; vWA_ATR; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR017360; Anthrax_toxin_rcpt.
DR InterPro; IPR008399; Anthrax_toxin_rcpt_C.
DR InterPro; IPR008400; Anthrax_toxin_rcpt_extracel.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR16059; ANTHRAX TOXIN RECEPTOR; 1.
DR PANTHER; PTHR16059:SF13; ANTHRAX TOXIN RECEPTOR 2; 1.
DR Pfam; PF05586; Ant_C; 1.
DR Pfam; PF05587; Anth_Ig; 1.
DR Pfam; PF00092; VWA; 1.
DR PIRSF; PIRSF038023; Anthrax_toxin_receptor_2; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR038023-2};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR038023};
KW Metal-binding {ECO:0000256|PIRNR:PIRNR038023,
KW ECO:0000256|PIRSR:PIRSR038023-1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|PIRNR:PIRNR038023,
KW ECO:0000313|RefSeq:XP_008691493.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..488
FT /note="Anthrax toxin receptor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5035418811"
FT TRANSMEM 320..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..213
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 422..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 52
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /evidence="ECO:0000256|PIRSR:PIRSR038023-1"
FT BINDING 54
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /evidence="ECO:0000256|PIRSR:PIRSR038023-1"
FT BINDING 118
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /evidence="ECO:0000256|PIRSR:PIRSR038023-1"
FT DISULFID 39..218
FT /evidence="ECO:0000256|PIRSR:PIRSR038023-2"
SQ SEQUENCE 488 AA; 53355 MW; 7E6382A6B757BA9B CRC64;
MVAGLSLARS PGSWLVPGLW LLVLSGPGGP VSAQEQPSCR GAFDLYFVLD KSGSVANNWI
EIYNFVQQLT ERFVSPQMRL SFIVFSSQAT IILPLTGDRS KISKGLEDLK RVSPVGETYI
HEGLKLANEQ IQKAGGFKAS SIIIALTDGK LDGLVPSYAE KEAKISRSFG ARVYCVGVLD
FEQAQLERIA DSKDQVFPVK GGFQALKGII NSILDRSCTE ILELRPSSVC VGDEFQIVLS
GRGFNLGSRD GSVLCTYTVN ETYTKSVNPV SVDLNSMLCP APALNKVGET LDVSVSFNGG
KSVISSSLIV TATECSSGTA AIIAILVLLL LLGIGLMWWF WPLCCKVVIK DPPPPPPPAP
KEEEEEPLPT KKWPTVDASY YGGRGVGGIK RMEVRWGDKG STEEGARLEK AKNAVVKIPE
EVEEPVRPRP PRPKPTYQPP QTKWYTPIKG RLDALWALLR RQYDRVSLMR PQEGDEGRCI
NFSRVPSQ
//
