ID A0A384C9U0_URSMA Unreviewed; 463 AA.
AC A0A384C9U0;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=E3 ubiquitin-protein ligase TRIM38 {ECO:0000313|RefSeq:XP_040500827.1, ECO:0000313|RefSeq:XP_040500828.1};
DE SubName: Full=Tripartite motif containing 38 {ECO:0000313|Ensembl:ENSUMAP00000028676};
GN Name=TRIM38 {ECO:0000313|Ensembl:ENSUMAP00000028676,
GN ECO:0000313|RefSeq:XP_040500827.1, ECO:0000313|RefSeq:XP_040500828.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_040500828.1};
RN [1] {ECO:0000313|Ensembl:ENSUMAP00000028676}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_040500827.1, ECO:0000313|RefSeq:XP_040500828.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_040500827.1,
RC ECO:0000313|RefSeq:XP_040500828.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_008691170.1; XM_008692948.1.
DR RefSeq; XP_040500827.1; XM_040644893.1.
DR RefSeq; XP_040500828.1; XM_040644894.1.
DR STRING; 29073.ENSUMAP00000028676; -.
DR Ensembl; ENSUMAT00000033913.1; ENSUMAP00000028676.1; ENSUMAG00000020830.1.
DR KEGG; umr:103665037; -.
DR OMA; FRVYQHS; -.
DR OrthoDB; 3453019at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0046598; P:positive regulation of viral entry into host cell; IEA:Ensembl.
DR CDD; cd19761; Bbox2_TRIM5-like; 1.
DR CDD; cd16600; RING-HC_TRIM38_C-IV; 1.
DR CDD; cd15815; SPRY_PRY_TRIM38; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR035790; SPRY/PRY_TRIM38.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24103; E3 UBIQUITIN-PROTEIN LIGASE TRIM; 1.
DR PANTHER; PTHR24103:SF47; E3 UBIQUITIN-PROTEIN LIGASE TRIM38; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF15227; zf-C3HC4_4; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 14..61
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 86..127
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 272..463
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT COILED 131..158
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 200..234
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 463 AA; 53356 MW; 5F3A179078132A5F CRC64;
MASATKKMKE EATCAICLFL MTEPVSISCG HSYCKLCIMN FLENLGPAET PSNMFACPQC
RAPFQLASLR PNKQLGSLIE AIKEMEHEMS CEEHGEHLHL FCEDESQLIC WRCERSPRHK
GHRTALIEEV CQDYKEKLQN AVTNLRQLEE ECMNLKVFTT KQISEWNEKI EIQKRKIQSD
FKNLQSFLQE EEKSHLWRLE KEKEQTLKRL RADEATLEQK SQELKSHILE LEEKCQGSAQ
KLLQDVKDTL RRSWAMTLER QEAHSLELHT VCNVSELYFD VKKMLRSYQV NVTLDPDTAH
RELILSEDRR QVTRGCLQEN LDNSSKRFSI LPCILGCEGF TSGRHYFEVD VGEGTGWDLG
VCLDNVHRDV GVIQKPQSGF WAIRLCKKKG YLALTSPITS LYLGEQPLVV GIFLDCDVGV
VSFYNMTTGS HIFTFPKASF SDTLRPYFRV YQHSPLFLPP PDE
//
