ID A0A384CC49_URSMA Unreviewed; 986 AA.
AC A0A384CC49;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU364117};
DE EC=3.6.4.12 {ECO:0000256|RuleBase:RU364117};
GN Name=RECQL5 {ECO:0000313|Ensembl:ENSUMAP00000012219,
GN ECO:0000313|RefSeq:XP_008691990.1, ECO:0000313|RefSeq:XP_008691991.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008691990.1};
RN [1] {ECO:0000313|Ensembl:ENSUMAP00000012219}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008691990.1, ECO:0000313|RefSeq:XP_008691991.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008691990.1,
RC ECO:0000313|RefSeq:XP_008691991.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU364117};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364117}.
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446, ECO:0000256|RuleBase:RU364117}.
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DR RefSeq; XP_008691990.1; XM_008693768.2.
DR RefSeq; XP_008691991.1; XM_008693769.2.
DR STRING; 29073.ENSUMAP00000012219; -.
DR Ensembl; ENSUMAT00000014517.1; ENSUMAP00000012219.1; ENSUMAG00000009115.1.
DR GeneID; 103665741; -.
DR KEGG; umr:103665741; -.
DR CTD; 9400; -.
DR OMA; WSDPGAC; -.
DR OrthoDB; 5474026at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005657; C:replication fork; IEA:Ensembl.
DR GO; GO:0097550; C:transcription preinitiation complex; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:Ensembl.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000993; F:RNA polymerase II complex binding; IEA:Ensembl.
DR GO; GO:0072757; P:cellular response to camptothecin; IEA:Ensembl.
DR GO; GO:0071466; P:cellular response to xenobiotic stimulus; IEA:Ensembl.
DR GO; GO:0051304; P:chromosome separation; IEA:Ensembl.
DR GO; GO:1990506; P:mitotic DNA-templated DNA replication; IEA:Ensembl.
DR GO; GO:2000042; P:negative regulation of double-strand break repair via homologous recombination; IEA:Ensembl.
DR GO; GO:0034244; P:negative regulation of transcription elongation by RNA polymerase II; IEA:Ensembl.
DR GO; GO:1990414; P:replication-born double-strand break repair via sister chromatid exchange; IEA:Ensembl.
DR CDD; cd18014; DEXHc_RecQ5; 1.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR Gene3D; 6.10.250.2460; -; 1.
DR Gene3D; 6.10.250.3140; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.1740.100; Set2, Rpb1 interacting domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010716; RECQ5.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR038190; SRI_sf.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF159; ATP-DEPENDENT DNA HELICASE Q5; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF06959; RecQ5; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU364117};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|RuleBase:RU364117};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU364117};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU364117}; Nucleus {ECO:0000256|RuleBase:RU364117};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680}.
FT DOMAIN 36..210
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 238..401
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 694..745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 763..868
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 986 AA; 107762 MW; B92409192C3C6C9F CRC64;
MSTHPSFDPE RRVRSTLKKV FGFDSFKTPL QESATMAVVR GDKDVFVCMP TGAGKSLCYQ
LPALLAKGIT IVISPLIALI QDQVDHLLAL KVRVSSLNSK LSAQEKKELL SDLEREKPQT
KLLYITPEMA ASASFQPTLN SLVSRHLLSY LVVDEAHCVS QWGHDFRPDY LRLGTLRSRL
AHAPCVALTA TATPQVQEDV FAALHLKQPV ATFKTPCFRA NLFYDVQFKE LLSDPYGNLR
DFCLKALGQK ADKGLLSGCG IVYCRTREAC EQLATELSHR GVSAKAYHAG LKASERTLVQ
NEWMEEKVPV IVATVSFGMG VDKANVRFVA HWNIAKSMAG YYQESGRAGR DGKPSWCRLY
YSRNDRDQVS FLIRKEVAKL QEKRGNKASD KAAVLAFDAL VTFCEGLGCR HAAIAKYFGD
APPACTKGCD HCRDPGALRK QLDALEHRSS WNKTCIGPSQ GNGFDPELYE GGRRGYGGFS
RYDEGSGGSG DEGRDEAHKR EWNLFYQKQM SLRKGKDPKI EEFVPPDEDC PLKEASSRKI
PRLTVKAREH CLGLLEEALS SNHQATDTTH GPDLQAKAVE LEHEMFRSAK AANLYKASVL
KKVAEIHRAS KDGQLYDVGS NTRSCSAQAQ PPEPSEYDIR PASQVYSLKP KRVGAGFPRG
SCSFQTAAEL TEKTWAEEQA PQPVRGAEWE VPSQPLGLQG EDCSEPLPGP RGEAPGSNAY
CGGSSPEKKV KSPSKGGAKA RASKKQQLLA AAALKDSQNI ARFCQRAKSP SPLTSAPGAE
GAGPSCEGVR GPPAAPEKCA GEEDGALGCL AVPPQTKECT RERPRACILG DQGPPEGQPT
PTKETHKGKR ARPQQENPEN QAQKRPRLSA NASILAEAKD SISASNQGTL NPTTQDSCLL
PAPGISLKEA ANVVVKCLTP FYKEGKFASK ELFKAFARHL SHSLTQKAFP GRSVKEEAQN
FIKQFFHGRA RCESEADWHG LCDPQR
//
