ID A0A384CDB7_URSMA Unreviewed; 513 AA.
AC A0A384CDB7;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Regulator of G-protein signaling 7 isoform X1 {ECO:0000313|RefSeq:XP_008692817.1};
GN Name=RGS7 {ECO:0000313|RefSeq:XP_008692817.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008692817.1};
RN [1] {ECO:0000313|RefSeq:XP_008692817.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008692817.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_008692817.1; XM_008694595.2.
DR AlphaFoldDB; A0A384CDB7; -.
DR GeneID; 103666543; -.
DR KEGG; umr:103666543; -.
DR CTD; 6000; -.
DR OrthoDB; 22856at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR CDD; cd04450; DEP_RGS7-like; 1.
DR CDD; cd00068; GGL; 1.
DR CDD; cd08738; RGS_RGS7; 1.
DR Gene3D; 1.10.1240.60; -; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR Gene3D; 4.10.260.10; Transducin (heterotrimeric G protein), gamma chain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR015898; G-protein_gamma-like_dom.
DR InterPro; IPR036284; GGL_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR047016; RGS6/7/9/11.
DR InterPro; IPR047017; RGS6/7/9/11_DHEX_sf.
DR InterPro; IPR040759; RGS_DHEX.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45746; LP21163P; 1.
DR PANTHER; PTHR45746:SF7; REGULATOR OF G-PROTEIN SIGNALING 7; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00631; G-gamma; 1.
DR Pfam; PF00615; RGS; 1.
DR Pfam; PF18148; RGS_DHEX; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00049; DEP; 1.
DR SMART; SM01224; G_gamma; 1.
DR SMART; SM00224; GGL; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF48670; Transducin (heterotrimeric G protein), gamma chain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700}.
FT DOMAIN 81..156
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 377..492
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
SQ SEQUENCE 513 AA; 59552 MW; 1F57627B6E0837AE CRC64;
MLHVGWSPPL STTIRISLKS PSPFAARRPV IPVSEISADQ LWGDMAQGNN YTQTSNGVAD
ESPNMLVYRK MEDVIARMQD EKNGIPIRTV KSFLSKIPSV FSGSDIVQWL IKNLTIEDPV
EALHLGTLMA AHGYFFPISD HVLTLKDDGT FYRFQTPYFW PSNCWEPENT DYAVYLCKRT
MQNKARLELA DYEAESLARL QRAFARKWEF IFMQAEAQAK VDKKRDKIER KILDSQERAF
WDVHRPVPGC VNTTEVDIKK SSRMRNPHKT RKSVYGLQND IRSHSPTHTP TPETKPPTEE
ELQQQIKYWQ IQLDRHRLKM SKVADSLLGY TEQYLEYDPF LVPPDPSNPW LSDDTTFWEL
EASKEPSQQR VKRWGFGMDE ALKDPVGREQ FLKFLESEFS SENLRFWLAV EDLKKRPIRE
VPSRVQEIWQ EFLAPGAPSA INLDSKSYDK TTQNVKEPGR YTFEDAQEHI YKLMKSDSYP
RFIRSSAYQE LLQAKKKGKS LTSKRLTSLV QSY
//
