ID A0A384CEV7_URSMA Unreviewed; 841 AA.
AC A0A384CEV7;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Taste 1 receptor member 1 {ECO:0000313|Ensembl:ENSUMAP00000033501};
DE SubName: Full=Taste receptor type 1 member 1 {ECO:0000313|RefSeq:XP_008692999.1};
GN Name=TAS1R1 {ECO:0000313|Ensembl:ENSUMAP00000033501,
GN ECO:0000313|RefSeq:XP_008692999.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008692999.1};
RN [1] {ECO:0000313|Ensembl:ENSUMAP00000033501}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008692999.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008692999.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_008692999.1; XM_008694777.2.
DR STRING; 29073.ENSUMAP00000033501; -.
DR Ensembl; ENSUMAT00000039637.1; ENSUMAP00000033501.1; ENSUMAG00000024146.1.
DR GeneID; 103666693; -.
DR KEGG; umr:103666693; -.
DR CTD; 80835; -.
DR OMA; EDWAIST; -.
DR OrthoDB; 4096532at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0008527; F:taste receptor activity; IEA:Ensembl.
DR GO; GO:0050917; P:sensory perception of umami taste; IEA:Ensembl.
DR CDD; cd15289; 7tmC_TAS1R1; 1.
DR CDD; cd06363; PBP1_taste_receptor; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF3; TASTE RECEPTOR TYPE 1 MEMBER 1; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00592; CASENSINGR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_008692999.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..841
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041072282"
FT TRANSMEM 568..592
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 604..623
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 635..660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 681..704
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 724..749
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 761..783
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 789..809
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 566..831
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 841 AA; 92638 MW; 7536889B2B5ADDE3 CRC64;
MSLLAAHLVS LQVSLSCCWA LSCHNTELSP DFSLPGDYLL AGLFPVHSHC PGVRRRPTVT
LCDRPNSFNG HGYHLFQAMR FGIEEINNST TLLPNVTLGY QLYDVCSESA NVYATLNVLS
MLGTHHIDIQ ANPAHYSPAA LAVIGPDTTN HAATTAALLG PFLVPLISYE ASSAMLGVKR
FYPSFLRTIP SDEHQVELMV LLLQSFGWVW ISLVGSDGDY GQLGVQALEE QATQQGICIA
FKDIIPLSAR PGSERMWSMM HHLARARTTV VVVFSNRQLA RVFFESVVLA NLTAKVWIAS
EDWAISRHIS SVPGVWGIGM VLGVAIQQRL VPGLKEFEEA YVQADKGAHG SCPSGSWCGS
NQLCSACRAF TAQQMPTLGA FSMSSAYNAY QAVYAVAHGL HRLLGCASGA CSRDRVYPWQ
LLEEIRKVNF LLHEDTVIFN DNGDPLGSYD IIAWDWSGPK WNFRVIGSAT WPPVQLDINK
TKIRWHGKDN QVPKSVCSSD CLEGHQRVIV GFYHCCFECV PCEAGTFLNK SDLHRCQPCG
KEEWAPEGSE TCFPRTVVFL TWHEPISWVL LAANTLLLLV VAGTAGLFAW HLDTPVVRSA
GGRLCFFMLG SLAGGSCGLY GFFGEPTLPT CLLRQGLFVL GFAIFLSCLT IRSFQLVFIF
KFSAKVPTFY HAWVQNHGPS LFVVISSMAQ LLICLTWLAV WTPLPTREYQ RFPQLVVLDC
SEANSLGFML AFAYNGLLSV SAFACSYLGK DLPENYNEAK CVTFSLLLNF VSWIGFFTTA
SVYQGKYLPA VNVLAALSSL SGGFSGYFLP KCYVILCRPD LNSTEHFQAS IQDYTRRCGS
T
//
