ID A0A384CGW1_URSMA Unreviewed; 112 AA.
AC A0A384CGW1;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Cytokine SCM-1 beta-like {ECO:0000313|Ensembl:ENSUMAP00000023872, ECO:0000313|RefSeq:XP_008694027.1};
GN Name=LOC103667626 {ECO:0000313|Ensembl:ENSUMAP00000023872,
GN ECO:0000313|RefSeq:XP_008694027.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008694027.1};
RN [1] {ECO:0000313|Ensembl:ENSUMAP00000023872}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008694027.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008694027.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the intercrine gamma family.
CC {ECO:0000256|ARBA:ARBA00006894}.
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DR RefSeq; XP_008694027.1; XM_008695805.2.
DR STRING; 29073.ENSUMAP00000023872; -.
DR Ensembl; ENSUMAT00000028272.1; ENSUMAP00000023872.1; ENSUMAG00000017370.1.
DR GeneID; 103667626; -.
DR KEGG; umr:103667626; -.
DR OMA; IKICADP; -.
DR OrthoDB; 4639980at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0008009; F:chemokine activity; IEA:Ensembl.
DR GO; GO:0071353; P:cellular response to interleukin-4; IEA:Ensembl.
DR GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEA:Ensembl.
DR GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0035782; P:mature natural killer cell chemotaxis; IEA:Ensembl.
DR GO; GO:2000538; P:positive regulation of B cell chemotaxis; IEA:Ensembl.
DR GO; GO:2000563; P:positive regulation of CD4-positive, alpha-beta T cell proliferation; IEA:Ensembl.
DR GO; GO:2000558; P:positive regulation of immunoglobulin production in mucosal tissue; IEA:Ensembl.
DR GO; GO:2000503; P:positive regulation of natural killer cell chemotaxis; IEA:Ensembl.
DR GO; GO:0090023; P:positive regulation of neutrophil chemotaxis; IEA:Ensembl.
DR GO; GO:0010820; P:positive regulation of T cell chemotaxis; IEA:Ensembl.
DR GO; GO:2000556; P:positive regulation of T-helper 1 cell cytokine production; IEA:Ensembl.
DR GO; GO:2000553; P:positive regulation of T-helper 2 cell cytokine production; IEA:Ensembl.
DR GO; GO:2000412; P:positive regulation of thymocyte migration; IEA:Ensembl.
DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:Ensembl.
DR CDD; cd00271; Chemokine_C; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR008105; Chemokine_XCL1/XCL2.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015:SF101; CYTOKINE SCM-1 BETA-RELATED; 1.
DR PANTHER; PTHR12015; SMALL INDUCIBLE CYTOKINE A; 1.
DR Pfam; PF00048; IL8; 1.
DR PRINTS; PR01731; LYMPHOTACTIN.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; Interleukin 8-like chemokines; 1.
PE 3: Inferred from homology;
KW Chemotaxis {ECO:0000256|ARBA:ARBA00022500};
KW Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..112
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041164929"
FT DOMAIN 28..84
FT /note="Chemokine interleukin-8-like"
FT /evidence="ECO:0000259|SMART:SM00199"
FT REGION 87..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 112 AA; 12348 MW; ADEEC2E7F1D20B62 CRC64;
MRPLLLALLG ICFLTEFIVE GVGSEVLERS ICVSLTTKRL PVKNIKTYTI KEGSMKAVIF
ITRRGLKVCA DPQADWVKKA VESVDKSTRR NVKQTQPTGA QHSTNTAVTL TT
//
