ID A0A384CH90_URSMA Unreviewed; 110 AA.
AC A0A384CH90;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Anaphase-promoting complex subunit 16 {ECO:0000256|ARBA:ARBA00013930};
DE AltName: Full=Cyclosome subunit 16 {ECO:0000256|ARBA:ARBA00031333};
GN Name=ANAPC16 {ECO:0000313|Ensembl:ENSUMAP00000011967,
GN ECO:0000313|RefSeq:XP_008694231.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008694231.1};
RN [1] {ECO:0000313|Ensembl:ENSUMAP00000011967}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008694231.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008694231.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls
CC progression through mitosis and the G1 phase of the cell cycle. The
CC APC/C complex acts by mediating ubiquitination and subsequent
CC degradation of target proteins: it mainly mediates the formation of
CC 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the
CC formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
CC {ECO:0000256|ARBA:ARBA00025025}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the APC16 family.
CC {ECO:0000256|ARBA:ARBA00007252}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_008694231.1; XM_008696009.2.
DR STRING; 29073.ENSUMAP00000011969; -.
DR Ensembl; ENSUMAT00000014239.1; ENSUMAP00000011967.1; ENSUMAG00000008968.1.
DR GeneID; 103667806; -.
DR KEGG; umr:103667806; -.
DR CTD; 119504; -.
DR OMA; ADNWRYK; -.
DR OrthoDB; 5318708at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005680; C:anaphase-promoting complex; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR InterPro; IPR029641; APC16.
DR PANTHER; PTHR31564; ANAPHASE-PROMOTING COMPLEX SUBUNIT 16; 1.
DR PANTHER; PTHR31564:SF0; ANAPHASE-PROMOTING COMPLEX SUBUNIT 16; 1.
DR Pfam; PF17256; ANAPC16; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680}.
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 110 AA; 11667 MW; F348FA92F4B89E4F CRC64;
MAASSSSSSA GGVSGSSVTG SGFSVSDLAP PRKALFTYPK GAGEMLEDGS ERFLCESVFS
YQVASTLKQV KHDQQVARME KLAGLVEELE ADEWRFKPIE QLLGFTPSSG
//
