ID A0A384CI44_URSMA Unreviewed; 699 AA.
AC A0A384CI44;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=EEF1A lysine and N-terminal methyltransferase {ECO:0000313|Ensembl:ENSUMAP00000024649, ECO:0000313|RefSeq:XP_008694513.1};
GN Name=EEF1AKNMT {ECO:0000313|RefSeq:XP_008694513.1};
GN Synonyms=METTL13 {ECO:0000313|Ensembl:ENSUMAP00000024649};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008694513.1};
RN [1] {ECO:0000313|Ensembl:ENSUMAP00000024649}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008694513.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008694513.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_008694513.1; XM_008696291.2.
DR STRING; 29073.ENSUMAP00000024649; -.
DR Ensembl; ENSUMAT00000029195.1; ENSUMAP00000024649.1; ENSUMAG00000017931.1.
DR GeneID; 103668008; -.
DR KEGG; umr:103668008; -.
DR CTD; 51603; -.
DR OMA; REIEWLF; -.
DR OrthoDB; 179741at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:Ensembl.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:1902807; P:negative regulation of cell cycle G1/S phase transition; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR025714; Methyltranfer_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; NF037959; MFS_SpdSyn; 1.
DR PANTHER; PTHR12176; SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN; 1.
DR PANTHER; PTHR12176:SF88; SPERMINE_SPERMIDINE SYNTHASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G08500); 1.
DR Pfam; PF13847; Methyltransf_31; 1.
DR Pfam; PF01564; Spermine_synth; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|RefSeq:XP_008694513.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 47..162
FT /note="Methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF13847"
FT REGION 433..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 699 AA; 78840 MW; 65ABBF2293115FAB CRC64;
MNLLPKSSRE FGSVDYWERF FQQRGKRAFE WYGSYLELCG VLHKYIKPRE KVLVIGCGNS
ELSEQLYDVG YQDIVNIDIS EVVIKQMKER NASRRPQMSF LKMDMTQMEF PDASFQVVLD
KGTLDAVLTD EEEKTLHQVD RMLAEVGRVL QVGGRYLCIS LAQAHILKKA VGHFSREGWM
VRVHQVANSQ DQVLEAEPRF SLPVFAFIMT KFRPVPGSAL QIFELCAQEQ GKPVRLESAE
QLAEAVRERQ QYAWLCSQLY RKAGLGSVSL DLCDGDTGEP RYTLHVVDSP TVKPSRDNHF
AIFIIPQGRE TEWLFGMEEG RKQLAASAGF RRLITVALHR GQRYESMDSI QAELSARVME
LAPAGVPAQQ QVPFLSVGGD IGVRTVQHQD CSPLSGSYVV EDVQGDDKHY FRRLIFLSNR
NVVQSEARLL KDVSHRAQKK RKKDRKKQRP ADTPEDLPAA PGQSIDKSYL CCEHHKAMIA
GLALLRNPEL LLETPLALLV VGLGGGSLPL FVHDHFPKSC IDAVEIDPSM LEVATQWFGF
SQSERMKVHI ADGLDYITSL AGREVRPHYN VIMFDVDSKD PTLGMSCPPP AFVDQPFLQK
VKSILTPEGV FILNLVCRDL GLKDSVLSGL KAVFPLLYVR RIEGEVNEIL FCQLHPEQKL
ATPELLEMAQ ALEQTLRKPG RGWDDTYVLS DMLKTVKIV
//
