ID A0A384CIW2_URSMA Unreviewed; 348 AA.
AC A0A384CIW2;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Interferon stimulated exonuclease gene 20 like 2 {ECO:0000313|Ensembl:ENSUMAP00000024408};
DE SubName: Full=Interferon-stimulated 20 kDa exonuclease-like 2 {ECO:0000313|RefSeq:XP_040491758.1};
GN Name=ISG20L2 {ECO:0000313|Ensembl:ENSUMAP00000024408,
GN ECO:0000313|RefSeq:XP_040491758.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Ensembl:ENSUMAP00000024408};
RN [1] {ECO:0000313|Ensembl:ENSUMAP00000024408}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_040491758.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_040491758.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_008694768.1; XM_008696546.1.
DR RefSeq; XP_040491758.1; XM_040635824.1.
DR STRING; 29073.ENSUMAP00000024408; -.
DR Ensembl; ENSUMAT00000028914.1; ENSUMAP00000024408.1; ENSUMAG00000017767.1.
DR KEGG; umr:103668339; -.
DR OMA; PCPIVDY; -.
DR OrthoDB; 5479236at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd06149; ISG20; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR037433; ISG20_DEDDh.
DR InterPro; IPR047021; REXO1/3/4-like.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR12801:SF78; INTERFERON-STIMULATED 20 KDA EXONUCLEASE-LIKE 2; 1.
DR PANTHER; PTHR12801; RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED; 1.
DR Pfam; PF00929; RNase_T; 1.
DR SMART; SM00479; EXOIII; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 4: Predicted;
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839,
KW ECO:0000313|RefSeq:XP_040491758.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022839,
KW ECO:0000313|RefSeq:XP_040491758.1};
KW Nuclease {ECO:0000256|ARBA:ARBA00022839,
KW ECO:0000313|RefSeq:XP_040491758.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680}.
FT DOMAIN 173..339
FT /note="Exonuclease"
FT /evidence="ECO:0000259|SMART:SM00479"
FT REGION 1..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 125..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..38
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..166
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 348 AA; 38634 MW; 189EEEA053EB6D7D CRC64;
MSTLLLNLDF GEPPPKKAFE GNAKHRKFVR KRRLLERRGF LNKKNQPPSK ASKLHSEPPK
KGETSSIDGT WKVSPLPKKK TVASSSGPEQ ALDKKAAVPW LTPAPAQKPG SAVAKVDLLG
EFQSALPKMR SHPTRPHKKG PQKNPTQKNA PQSSTQSHSD NKCSGASQKM PRKMVAIDCE
MVGTGPKGHV SSLARCSIVN YHGDVLYDEY ILPPCHIVDY RTRWSGIRKQ HMVNATPFKT
ARSQILKILA GKIVVGHAIH NDFKALQYFH PKSLTRDTSH IPPLNRKADC PENATMSLKT
LTKKLLNRDI QVGRSGHSSV EDAQATMELY KLVEAEWEQH LAQSPPED
//
