ID A0A384CKN9_URSMA Unreviewed; 641 AA.
AC A0A384CKN9;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Amiloride-sensitive sodium channel subunit beta {ECO:0000256|ARBA:ARBA00039757};
DE AltName: Full=Beta-NaCH {ECO:0000256|ARBA:ARBA00043222};
DE AltName: Full=Epithelial Na(+) channel subunit beta {ECO:0000256|ARBA:ARBA00042602};
DE AltName: Full=Nonvoltage-gated sodium channel 1 subunit beta {ECO:0000256|ARBA:ARBA00042734};
DE AltName: Full=SCNEB {ECO:0000256|ARBA:ARBA00041932};
GN Name=SCNN1B {ECO:0000313|Ensembl:ENSUMAP00000012663,
GN ECO:0000313|RefSeq:XP_008695387.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008695387.1};
RN [1] {ECO:0000313|Ensembl:ENSUMAP00000012663}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008695387.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008695387.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004424}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004156}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. SCNN1B subfamily. {ECO:0000256|ARBA:ARBA00038224}.
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DR RefSeq; XP_008695387.1; XM_008697165.1.
DR STRING; 29073.ENSUMAP00000012663; -.
DR Ensembl; ENSUMAT00000015025.1; ENSUMAP00000012663.1; ENSUMAG00000009398.1.
DR GeneID; 103668861; -.
DR KEGG; umr:103668861; -.
DR CTD; 6338; -.
DR OMA; QRETCIS; -.
DR OrthoDB; 5344287at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR GO; GO:0034706; C:sodium channel complex; IEA:Ensembl.
DR GO; GO:0015280; F:ligand-gated sodium channel activity; IEA:Ensembl.
DR GO; GO:0050699; F:WW domain binding; IEA:Ensembl.
DR GO; GO:0032341; P:aldosterone metabolic process; IEA:Ensembl.
DR GO; GO:0014824; P:artery smooth muscle contraction; IEA:Ensembl.
DR GO; GO:0071468; P:cellular response to acidic pH; IEA:Ensembl.
DR GO; GO:1904045; P:cellular response to aldosterone; IEA:Ensembl.
DR GO; GO:0042045; P:epithelial fluid transport; IEA:Ensembl.
DR GO; GO:0034101; P:erythrocyte homeostasis; IEA:Ensembl.
DR GO; GO:0010467; P:gene expression; IEA:Ensembl.
DR GO; GO:0006883; P:intracellular sodium ion homeostasis; IEA:Ensembl.
DR GO; GO:0002269; P:leukocyte activation involved in inflammatory response; IEA:Ensembl.
DR GO; GO:0070254; P:mucus secretion; IEA:Ensembl.
DR GO; GO:0035264; P:multicellular organism growth; IEA:Ensembl.
DR GO; GO:0050891; P:multicellular organismal-level water homeostasis; IEA:Ensembl.
DR GO; GO:0002283; P:neutrophil activation involved in immune response; IEA:Ensembl.
DR GO; GO:0070944; P:neutrophil-mediated killing of bacterium; IEA:Ensembl.
DR GO; GO:0055075; P:potassium ion homeostasis; IEA:Ensembl.
DR GO; GO:0003014; P:renal system process; IEA:Ensembl.
DR GO; GO:0032094; P:response to food; IEA:Ensembl.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR GO; GO:0050909; P:sensory perception of taste; IEA:UniProtKB-KW.
DR GO; GO:0098719; P:sodium ion import across plasma membrane; IEA:Ensembl.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR Gene3D; 1.10.287.770; YojJ-like; 1.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR004724; ENaC_chordates.
DR InterPro; IPR020903; ENaC_CS.
DR NCBIfam; TIGR00859; ENaC; 1.
DR PANTHER; PTHR11690:SF18; AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT BETA; 1.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
DR PROSITE; PS01206; ASC; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Ion channel {ECO:0000313|RefSeq:XP_008695387.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Taste {ECO:0000256|ARBA:ARBA00022480};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022461}.
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 593..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..621
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 641 AA; 72565 MW; 492DCA47A3F9F347 CRC64;
MHMKKYLVKC LHRLQKGPGY TYKELLVWYC NNTNTHGPKR IICEGPKKKA MWFLITLLFT
SLVCWQWSVF IKTYLSWEVS VSLSVGFKTM DFPAVTICNA SPFQYSKVKH LLQDLDELME
AVLERILAPE QSYSNATRTL NFTIWNDTPL VLIDERNPHH PVVLDLFGDV HNGSASSSPA
PGRTCTAQGC KVAMRLCSLN GTVCTFRNFT SATQAVTEWY LLQATNIFSQ VPTHELVEMG
YPAERLILAC LFGPEPCSYR NFTSIFQPDY GNCYIFNWGM TEKALPSANP GAEFGLKLIL
DIGQEDYVPF LTSTAGARLL LHEQRSYPFI KDEGIYAMSG TETSIGVLVD KLERKGEPYS
QCTMNGSDVP VQNLYSDYNT TYSIQACIRS CFQEHMIQNC SCGHYLYPLP HGERYCNNRE
FPDWAYCYSH LSMSVAQRET CINMCKESCN DTQYKMTISM ADWPSEASED WIFHVLSQER
DQSTNITLSR KGVVKLNIYF QEFNYRTIEE SAANNIVWLL SNLGGQFGFW MGGSVLCLIE
FGEIVIDFVW ITIIKLVAFA KSLRQKRVQA RYAGPPPTVA ELVEAHTNFG FQPDVARPGP
EPGTYPDEQT LPIPGTPPPN YDSLRLQPLD VIESDSEGDA I
//
