ID A0A384CLP5_URSMA Unreviewed; 118 AA.
AC A0A384CLP5;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=D-dopachrome decarboxylase {ECO:0000256|ARBA:ARBA00038884};
DE EC=4.1.1.84 {ECO:0000256|ARBA:ARBA00038884};
GN Name=LOC103669207 {ECO:0000313|RefSeq:XP_008695751.1};
GN Synonyms=DDT {ECO:0000313|Ensembl:ENSUMAP00000003991};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008695751.1};
RN [1] {ECO:0000313|Ensembl:ENSUMAP00000003991}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008695751.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008695751.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Tautomerization of D-dopachrome with decarboxylation to give
CC 5,6-dihydroxyindole (DHI). {ECO:0000256|ARBA:ARBA00037460}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000256|ARBA:ARBA00011233}.
CC -!- SIMILARITY: Belongs to the MIF family. {ECO:0000256|ARBA:ARBA00005851}.
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DR RefSeq; XP_008695751.1; XM_008697529.2.
DR STRING; 29073.ENSUMAP00000003991; -.
DR Ensembl; ENSUMAT00000004874.1; ENSUMAP00000003991.1; ENSUMAG00000003262.1.
DR GeneID; 103669207; -.
DR KEGG; umr:103669207; -.
DR OMA; PDRINIR; -.
DR OrthoDB; 5383722at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR GO; GO:0042438; P:melanin biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
DR Gene3D; 3.30.429.10; Macrophage Migration Inhibitory Factor; 1.
DR InterPro; IPR001398; Macrophage_inhib_fac.
DR InterPro; IPR019829; Macrophage_inhib_fac_CS.
DR InterPro; IPR014347; Tautomerase/MIF_sf.
DR PANTHER; PTHR11954; D-DOPACHROME DECARBOXYLASE; 1.
DR PANTHER; PTHR11954:SF22; D-DOPACHROME DECARBOXYLASE; 1.
DR Pfam; PF01187; MIF; 1.
DR SUPFAM; SSF55331; Tautomerase/MIF; 1.
DR PROSITE; PS01158; MIF; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Melanin biosynthesis {ECO:0000256|ARBA:ARBA00023101};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680}.
SQ SEQUENCE 118 AA; 12793 MW; 4FE737297548D333 CRC64;
MPFVELDTNL PAGRVPAGLE KRLCAATAAI LSKPEDRVNV TVRPGLAMAV NGSTEPCAQL
LISSIGVVGT AEDNRGHSAR FFEFLTKELN LGQDRIIIRF FPVEPWQIGK KGTVVTFL
//
