ID A0A384CMW2_URSMA Unreviewed; 1458 AA.
AC A0A384CMW2;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Histone-lysine N-methyltransferase SETD5 isoform X7 {ECO:0000313|RefSeq:XP_008696148.1};
DE SubName: Full=SET domain containing 5 {ECO:0000313|Ensembl:ENSUMAP00000026419};
GN Name=SETD5 {ECO:0000313|Ensembl:ENSUMAP00000026419,
GN ECO:0000313|RefSeq:XP_008696148.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008696148.1};
RN [1] {ECO:0000313|Ensembl:ENSUMAP00000026419}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008696148.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008696148.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_008696148.1; XM_008697926.2.
DR STRING; 29073.ENSUMAP00000026419; -.
DR Ensembl; ENSUMAT00000031269.1; ENSUMAP00000026419.1; ENSUMAG00000019048.1.
DR GeneID; 103669580; -.
DR CTD; 55209; -.
DR OMA; XVSLLEY; -.
DR OrthoDB; 2919208at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0000791; C:euchromatin; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0046975; F:histone H3K36 methyltransferase activity; IEA:Ensembl.
DR GO; GO:0046974; F:histone H3K9 methyltransferase activity; IEA:Ensembl.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl.
DR GO; GO:0050890; P:cognition; IEA:Ensembl.
DR GO; GO:0016480; P:negative regulation of transcription by RNA polymerase III; IEA:Ensembl.
DR GO; GO:1902275; P:regulation of chromatin organization; IEA:Ensembl.
DR GO; GO:0032784; P:regulation of DNA-templated transcription elongation; IEA:Ensembl.
DR GO; GO:0051963; P:regulation of synapse assembly; IEA:Ensembl.
DR CDD; cd19181; SET_SETD5; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR044433; SETD5_SET.
DR PANTHER; PTHR46462:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE SETD5; 1.
DR PANTHER; PTHR46462; UPSET, ISOFORM A; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000261680}.
FT DOMAIN 288..409
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 1..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 182..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 434..694
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 867..899
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 947..985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1053..1245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1259..1458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..199
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..452
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 456..471
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..490
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..556
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..611
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 869..891
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1083..1098
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1102..1184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1259..1433
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1458 AA; 159129 MW; 86406C496045BAC7 CRC64;
MSIAIPLGVT TPDTSYSDMA AGSDPESVEA SPAVNEKSVY STHNYGTTQR HGCRGLPYAD
HNYGAPPPPT PPASPPVQTI IPRSDLNGLP SPVEERCGDS PNSEGETVPT WCPCGLSQDG
FLLNCDKCRG MSRGKVIRLH RRKQDNISGG DSSATESWDE ELSPSTVLYT ATQHTPTSIT
LTVRRTKPKK RKKSPEKGRA AAKTKKIKNS PSEAQNLDEN TTEGWENRIR LWTDQYEEAF
TNQYSADVQN ALEQHLHSSK EFVGKPAILD TINKTELACN NTVIGSQMQL QLGRVTRVQK
HRKILRAARD LALDTLIIEY RGKVMLRQQF EVNGHFFKKP YPFVLFYSKF NGVEMCVDAR
TFGNDARFIR RSCTPNAEVR HMIADGMIHL CIYAVSAITK DAEVTIAFDY EYSNCNYKVD
CACHKGNRNC PIQKRNPNAA EPPLPPPPSL PTIGAETRRR KARRKELEME QQNEAPEEDN
SQQPEQVPEK ATVSSDHEEI DNPEEKAEEE KEEVTDDQEN PAHSRRTRED RKVEAIMHAF
ENLEKRKKRR DQPLEQSSSD IEITTTTSEV PVGEEAKTEA PEPEVSNPAS NMAIPSTPQS
VGVNTRRSSQ AGDVAAEKPV PKPPPAKPSR PRPKSRISRY RASSAQRLKR QKQAIAQQAE
LSQAALEDGG NNSSVTPTEA GNIDSSGENR QLMGSDPTVV SFTGSHVNRA APKYPKTKKY
LVTEWLNDKA EKQECPVECP LRITTDPTVL ATTLNMLPGL IHSPLICTTP KHYIRFGSPF
IPERRRRPLL PDGTFSSCKK RWIKQALEEG MTQTSSVPQE TRAQHLYQSN ENSNSSSICK
DNADLLSPLK KWKSRYLMEQ NVTKLLRPLS PVTPPPPNPG SKSPPLTTPG PSHPEEECRN
GYSLMFSPIT SLTTASRCNT PLQFELCHRK DLDLTKVGYL DSNTNSCADR PSLINSGPSD
LAPHPSIGPP SETGFPSRSG DGHQTLARNS DQAFRTEFNL MYAYSPLNAM PRADGLYRGS
PLVGDRKPLH LDGGYCSPAE GFPSRYEHGF MKDLSRGSMS PGGERACEGV PSAPQNPPQR
KKVSLLEYRK RKQEAKENSA GGGGDSAQSK IKSAGAGQGS SNSLSDTGAH GVQGSSTRTP
SSPHKKFSPS HSSMSHMEAV SPSDSRGTSS HCRPQENISS RWMVPTSVER LREGGSIPKV
LRSSVRVAQK GEPSPTWESN ITEKDSDPTD GEGPETLSSA LSKGAAVYSP SRYSYQLLQC
DSPRTESQSL LQQSSSPFRG HPTQSPGYSY RTTALRPGNP PSHGSSESSL SSTSYSSPAH
PVSTDSLAPF TGTPGYYSSQ PHSGNSTGSN LPRRSCPSSA ASPTPQGPSD SPTSDSVSQS
STGTLSSTSF PQNSRSSLPS DLRTISLPSA GQSAAYQASR VSAVSNSQHY PHRGSGGVHQ
YRLQPLQGSG VKTQTGLS
//
