UniProt: A0A384CQD9

Database: UniProt
Entry: A0A384CQD9_URSMA

LinkDB:  A0A384CQD9_URSMA 
Original site:  A0A384CQD9_URSMA

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Ontology (5)   
   GO (5)   
Gene (1)   
   KEGG GENES (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (36)   
   InterPro (17)   
   Pfam (11)   
   PROSITE (3)   
   SMART (5)   
All databases (43)   

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ID   A0A384CQD9_URSMA        Unreviewed;      1679 AA.
AC   A0A384CQD9;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   03-AUG-2022, sequence version 2.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Complement C5 {ECO:0000313|RefSeq:XP_008697047.2};
GN   Name=C5 {ECO:0000313|RefSeq:XP_008697047.2};
OS   Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008697047.2};
RN   [1] {ECO:0000313|RefSeq:XP_008697047.2}
RP   IDENTIFICATION.
RC   TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008697047.2};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR   RefSeq; XP_008697047.2; XM_008698825.2.
DR   STRING; 29073.ENSUMAP00000005084; -.
DR   KEGG; umr:103670372; -.
DR   OrthoDB; 4033541at2759; -.
DR   Proteomes; UP000261680; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   GO; GO:0006957; P:complement activation, alternative pathway; IEA:UniProtKB-KW.
DR   GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   CDD; cd00017; ANATO; 1.
DR   CDD; cd02896; complement_C3_C4_C5; 1.
DR   CDD; cd03582; NTR_complement_C5; 1.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 2.20.130.20; -; 1.
DR   Gene3D; 2.40.50.120; -; 1.
DR   Gene3D; 2.60.120.1540; -; 1.
DR   Gene3D; 2.60.40.1930; -; 3.
DR   Gene3D; 2.60.40.1940; -; 1.
DR   Gene3D; 6.20.50.160; -; 1.
DR   Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR   Gene3D; 1.20.91.20; Anaphylotoxins (complement system); 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR   InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR011626; Alpha-macroglobulin_TED.
DR   InterPro; IPR000020; Anaphylatoxin/fibulin.
DR   InterPro; IPR018081; Anaphylatoxin_comp_syst.
DR   InterPro; IPR041425; C3/4/5_MG1.
DR   InterPro; IPR048843; C5_CUB.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR041555; MG3.
DR   InterPro; IPR040839; MG4.
DR   InterPro; IPR001134; Netrin_domain.
DR   InterPro; IPR018933; Netrin_module_non-TIMP.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   InterPro; IPR008993; TIMP-like_OB-fold.
DR   PANTHER; PTHR11412:SF83; COMPLEMENT C5; 1.
DR   PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF07677; A2M_recep; 1.
DR   Pfam; PF01821; ANATO; 1.
DR   Pfam; PF21309; C5_CUB; 1.
DR   Pfam; PF17790; MG1; 1.
DR   Pfam; PF01835; MG2; 1.
DR   Pfam; PF17791; MG3; 1.
DR   Pfam; PF17789; MG4; 1.
DR   Pfam; PF01759; NTR; 1.
DR   Pfam; PF07678; TED_complement; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
DR   SMART; SM01361; A2M_recep; 1.
DR   SMART; SM00104; ANATO; 1.
DR   SMART; SM00643; C345C; 1.
DR   SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR   SUPFAM; SSF47686; Anaphylotoxins (complement system); 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR   SUPFAM; SSF50242; TIMP-like; 1.
DR   PROSITE; PS01177; ANAPHYLATOXIN_1; 1.
DR   PROSITE; PS01178; ANAPHYLATOXIN_2; 1.
DR   PROSITE; PS50189; NTR; 1.
PE   4: Predicted;
KW   Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW   Complement alternate pathway {ECO:0000256|ARBA:ARBA00023162};
KW   Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..1679
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5035465869"
FT   DOMAIN          698..732
FT                   /note="Anaphylatoxin-like"
FT                   /evidence="ECO:0000259|PROSITE:PS01178"
FT   DOMAIN          1532..1676
FT                   /note="NTR"
FT                   /evidence="ECO:0000259|PROSITE:PS50189"
SQ   SEQUENCE   1679 AA;  188850 MW;  2AA7F503AEA1F5A9 CRC64;
     MGLWGILCFL IFLGKSWGQE QTYVISAPKV FRVGASENIV IQVYGYTEEF DATISIKSYP
     DKKFTYSSGH VTLSSENKFQ NAAVLTIQPK QLSGGQNPVS HVYLEVVSRH FSRSKKVPVI
     YDNGFLFIHT DKPVYTPQQS VKVRVYSLND DMKPAKRETV LTYIDPEGSE VDIVEENDYT
     GIISFPDFKI PSNPKYGVWT IRAKYKEDFS TTGTTYFEIK EYVMPHFSVS IEPEKNFIGY
     KDFTDFEITI RARYFYNKVV TEAEVYITFG IRNDLKDDQK EMMQKALQNT MLINGVAQIT
     FNSETAIKEL SYDSLEDLDN KYLYIGVTVI ESTGGFSEEA EIPGIRYVLS PYKLNLVATP
     LFLKPGIPYS VKVQVKDSLD QVVGGVPVTL SAHTVDGNQE TSDLESKKSV TRSNDGVASF
     VVNLPSGATV LEFNVRTDDP DLPEENQASK DYQAIAYSSL SQSYLYIDWI ENYKPLLVGE
     YLNVIVTPRS PYIDKITHYN YLILSKGKIV HFGTREKLPD SSYQSINIPV TQNMVPSARL
     LVYYIVTGEQ TAELVSDSVW LNIEEKCGNQ LQVHLSPRAV AFSPGQRVSL DMATESNSWV
     ALSAVDSAIY GVQRRAKKPL ERVFQALETS DLGCGAGGGR NNADVFHLAG LTFLTNANAD
     DTQENDEPCK EILRPRRMLR KKIEEEVAKY KHAILKKCCY DGAFLNYDET CEQRAARIKI
     GPRCVRIFKE CCIIASQLRA EESHKNLQLG RLHIKTLLPV TKPEIRSYFP ESWLWEVHHV
     SRRSQLQLVL PDSLTTWEIQ GVGISDSGIC VADTLKAQVF KDVFLEMNIP YSVVRGEQIQ
     LKGTVYNYRT FGIRFCVRMS AVEGICTSGS PAIDHQGSSH SKCLSQSVEG SSSHLVTFTM
     LPLEIGLHNI SFSLETSLGK EILIKTLRVV PEGVKKESYA GVTLDPRGIY GVVSRRKEFP
     YRVPLDLVPK TKVKRIVSVK GLLIGEVMST VLSQEGIDIL THLPKGNAEA ELMSIVPVFY
     VFHYLEAGNN WNIFSTNSLT EKQNLKRKLK EGLVSIMSYR NADYSYSMWK GGSASTWLTA
     FVLRVLGQVN TYINQNQNSI CNAILWLVEN CQLENGSFKE NSQYQPIKLQ GTLPVEAREN
     TLYLTAFSVI GIRKAFDICP VVKISTALTK ADTFLLENTL STQSTFTLAI AAYALSLGDK
     SHPQFHSIVS ALKRKALVKG DPVIYRFWKD NPQQQDRSTP NVGTAHMVET TAYALLTSLS
     LKDINYVNPI IKWLSEEQRY GGGFYSTQDT INAIEGLTEY SLMIKQLHLD MDINVSYKRK
     GDLHHYKMTE KNFLGRPIEV PLNDDLVVST GYSNGLATVH VTTVVQKTST SEEICSFHLK
     IETQDIEASS YRGYGDSDYK RIVACASYKP SKEESSSGSS HAVMDISLPT GISANPEDLR
     VLVEGVDQLL TDYQIKDGHI IMQLNSIPSD EFLCVRFRIF ELFQVGFLSP ATFMVYEYHR
     PDKRCTMFYN PSDTKLQKVC EGVTCKCVEA DCGQMQTELD LTISADTRKE TACKPDIAYA
     YKVRITSITE ENVFIKYTAT LLDIYKAGEA VAEKDSEITF IKKATCANAD LEKGRQYLIM
     GKEALQIKYN FSFKYIYPLD SSTWIEYWPT DTTCPSCSAF LANLDEFAED IFLNGCENP
//

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