ID   A0A384CRZ2_URSMA        Unreviewed;       310 AA.
AC   A0A384CRZ2;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   03-AUG-2022, sequence version 2.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Phosphopantothenate--cysteine ligase isoform X1 {ECO:0000313|RefSeq:XP_008697573.2};
GN   Name=PPCS {ECO:0000313|RefSeq:XP_008697573.2};
OS   Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008697573.2};
RN   [1] {ECO:0000313|RefSeq:XP_008697573.2}
RP   IDENTIFICATION.
RC   TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008697573.2};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the PPC synthetase family.
CC       {ECO:0000256|ARBA:ARBA00005703}.
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DR   RefSeq; XP_008697573.2; XM_008699351.2.
DR   AlphaFoldDB; A0A384CRZ2; -.
DR   STRING; 29073.ENSUMAP00000033831; -.
DR   OrthoDB; 6287at2759; -.
DR   Proteomes; UP000261680; Unplaced.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProt.
DR   Gene3D; 3.40.50.10300; CoaB-like; 1.
DR   InterPro; IPR035929; CoaB-like_sf.
DR   InterPro; IPR007085; DNA/pantothenate-metab_flavo_C.
DR   PANTHER; PTHR12290; CORNICHON-RELATED; 1.
DR   PANTHER; PTHR12290:SF2; PHOSPHOPANTOTHENATE--CYSTEINE LIGASE; 1.
DR   Pfam; PF04127; DFP; 2.
DR   SUPFAM; SSF102645; CoaB-like; 1.
PE   3: Inferred from homology;
KW   Ligase {ECO:0000313|RefSeq:XP_008697573.2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261680}.
FT   DOMAIN          36..83
FT                   /note="DNA/pantothenate metabolism flavoprotein C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF04127"
FT   DOMAIN          161..264
FT                   /note="DNA/pantothenate metabolism flavoprotein C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF04127"
SQ   SEQUENCE   310 AA;  33723 MW;  1CAA72200978E796 CRC64;
     MADVDLVAEF PKPADAARFA EVMARFAARL GAQGRRVVLI TSGGTKVPLE ARPVRFLDNF
     SSGRRGAASA EAFLAAGYGV LFLYRARSAF PYAHRFPPQT WLSALRPCGA APSGLLSLEA
     EENALPGFAA ALRSYQEAAA AGTFLAVEFT TLADYLHLLQ AAAQALNPLG SSAMFYLAAA
     VSDFYVPVSE MPEHKIQSSR GPLQITMKMV PKMLSPLVKD WAPKAFIISF KLETDPSIVI
     DRARNALEVY RHQVVVANSL ESRRSSVVIL TKDSETKILL SEEEVVKGID IEEKIVGDLQ
     SRHTAFIHDN
//