ID A0A384CSF5_URSMA Unreviewed; 200 AA.
AC A0A384CSF5;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=RAB7B, member RAS oncogene family {ECO:0000313|Ensembl:ENSUMAP00000004948};
DE SubName: Full=Ras-related protein Rab-7b isoform X2 {ECO:0000313|RefSeq:XP_008697766.1};
GN Name=RAB7B {ECO:0000313|Ensembl:ENSUMAP00000004948,
GN ECO:0000313|RefSeq:XP_008697766.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008697766.1};
RN [1] {ECO:0000313|Ensembl:ENSUMAP00000004948}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008697766.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008697766.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000256|ARBA:ARBA00006270}.
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DR RefSeq; XP_008697766.1; XM_008699544.2.
DR RefSeq; XP_008697767.1; XM_008699545.1.
DR STRING; 29073.ENSUMAP00000004948; -.
DR Ensembl; ENSUMAT00000005985.1; ENSUMAP00000004948.1; ENSUMAG00000003956.1.
DR Ensembl; ENSUMAT00000005989.1; ENSUMAP00000004949.1; ENSUMAG00000003956.1.
DR GeneID; 103670999; -.
DR KEGG; umr:103670999; -.
DR CTD; 338382; -.
DR OMA; ASSWCKE; -.
DR OrthoDB; 586759at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR GO; GO:0045335; C:phagocytic vesicle; IEA:Ensembl.
DR GO; GO:0005802; C:trans-Golgi network; IEA:Ensembl.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0071346; P:cellular response to type II interferon; IEA:Ensembl.
DR GO; GO:0034499; P:late endosome to Golgi transport; IEA:Ensembl.
DR GO; GO:0034144; P:negative regulation of toll-like receptor 4 signaling pathway; IEA:Ensembl.
DR GO; GO:0034164; P:negative regulation of toll-like receptor 9 signaling pathway; IEA:Ensembl.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0045654; P:positive regulation of megakaryocyte differentiation; IEA:Ensembl.
DR CDD; cd00154; Rab; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR47981; RAB FAMILY; 1.
DR PANTHER; PTHR47981:SF22; RAS-RELATED PROTEIN RAB-7B; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00176; RAN; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51417; ARF; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
DR PROSITE; PS51420; RHO; 1.
PE 3: Inferred from homology;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680}.
SQ SEQUENCE 200 AA; 22651 MW; 0BCAD01AAFEC32F9 CRC64;
MNPRKKVDLK LIIIGALGVG KTSLLHQYVH KTFYEDYQTT LGASILSKII ILDDTTLKLQ
IWDTGGQERF RSMVSTFYKG SDGCILAFDV TDLESFEALD TWRGDVLAKT IPMEPSYPMV
VLGNKIDLAD RQVPQEVAQG WCKEKDIPYF EVSAKNDINV VQAFEMLASR ALSRYRSVLE
NYLTDSIKLS PEDQPRSRCC
//
