ID A0A384CU67_URSMA Unreviewed; 127 AA.
AC A0A384CU67;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=NPC intracellular cholesterol transporter 2 {ECO:0000256|ARBA:ARBA00021477};
DE AltName: Full=Epididymal secretory protein E1 {ECO:0000256|ARBA:ARBA00032516};
GN Name=NPC2 {ECO:0000313|RefSeq:XP_008698025.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008698025.1};
RN [1] {ECO:0000313|RefSeq:XP_008698025.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008698025.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the NPC2 family.
CC {ECO:0000256|ARBA:ARBA00006370}.
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DR RefSeq; XP_008698025.1; XM_008699803.2.
DR AlphaFoldDB; A0A384CU67; -.
DR GeneID; 103671186; -.
DR CTD; 10577; -.
DR OrthoDB; 2545683at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0032934; F:sterol binding; IEA:InterPro.
DR GO; GO:0032367; P:intracellular cholesterol transport; IEA:InterPro.
DR CDD; cd00916; Npc2_like; 1.
DR Gene3D; 2.60.40.770; -; 1.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR003172; ML_dom.
DR InterPro; IPR033916; ML_Npc2-like.
DR InterPro; IPR039670; NPC2-like.
DR PANTHER; PTHR11306; NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED; 1.
DR PANTHER; PTHR11306:SF73; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 2; 1.
DR Pfam; PF02221; E1_DerP2_DerF2; 1.
DR SMART; SM00737; ML; 1.
DR SUPFAM; SSF81296; E set domains; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..127
FT /note="NPC intracellular cholesterol transporter 2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016896439"
FT DOMAIN 24..127
FT /note="MD-2-related lipid-recognition"
FT /evidence="ECO:0000259|SMART:SM00737"
SQ SEQUENCE 127 AA; 13353 MW; F9E205D888B09BC8 CRC64;
MRVLVAASLL LALGASALAE PVHFKDCGSG LGVIKELNVN PCPTQPCKLH KGQSYSVNVT
FTSNIPSQSS KAVVHGILLG VPIPFPIPEA DGCKSGINCP IQKGKTYSYL NKLPVKNEYP
SCFPGSS
//
