ID A0A384CV08_URSMA Unreviewed; 734 AA.
AC A0A384CV08;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=ATP-dependent RNA helicase DDX1 {ECO:0000256|ARBA:ARBA00014916};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
DE AltName: Full=DEAD box protein 1 {ECO:0000256|ARBA:ARBA00032348};
GN Name=DDX1 {ECO:0000313|Ensembl:ENSUMAP00000032521};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Ensembl:ENSUMAP00000032521};
RN [1] {ECO:0000313|Ensembl:ENSUMAP00000032521}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic granule
CC {ECO:0000256|ARBA:ARBA00004463}. Mitochondrion
CC {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX1 subfamily.
CC {ECO:0000256|ARBA:ARBA00008765}.
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DR RefSeq; XP_008698636.1; XM_008700414.1.
DR AlphaFoldDB; A0A384CV08; -.
DR STRING; 29073.ENSUMAP00000032521; -.
DR Ensembl; ENSUMAT00000038472.1; ENSUMAP00000032521.1; ENSUMAG00000023450.1.
DR OMA; EYCIRAI; -.
DR OrthoDB; 102545at2759; -.
DR GO; GO:0071920; C:cleavage body; IEA:Ensembl.
DR GO; GO:0010494; C:cytoplasmic stress granule; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:Ensembl.
DR GO; GO:0072669; C:tRNA-splicing ligase complex; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0033677; F:DNA/RNA helicase activity; IEA:Ensembl.
DR GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0008143; F:poly(A) binding; IEA:Ensembl.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:Ensembl.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:Ensembl.
DR GO; GO:0006302; P:double-strand break repair; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0002735; P:positive regulation of myeloid dendritic cell cytokine production; IEA:Ensembl.
DR GO; GO:1903608; P:protein localization to cytoplasmic stress granule; IEA:Ensembl.
DR GO; GO:0043330; P:response to exogenous dsRNA; IEA:Ensembl.
DR GO; GO:0009615; P:response to virus; IEA:Ensembl.
DR GO; GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; IEA:Ensembl.
DR CDD; cd17938; DEADc_DDX1; 1.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR CDD; cd12873; SPRY_DDX1; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR47958; ATP-DEPENDENT RNA HELICASE DBP3; 1.
DR PANTHER; PTHR47958:SF186; ATP-DEPENDENT RNA HELICASE DDX1; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00622; SPRY; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
SQ SEQUENCE 734 AA; 81809 MW; DDF4CEF35BEC7092 CRC64;
MGVMPEIAQA VEEMDWLLPT DIQAESIPLI LGGGDVLMAA ETGSGKTGAF SIPVIQIVYE
TLKDQQEGKK GKTTIKTGAS VLNKWQMNPY DRGSAFAIGS DGLCCQSREV KEWHGCRATK
GLTKGKHYYE VSCHDQGLCR VGWSSMQASL DLGTDKFGFG FGGTGKKSHN KQFDNYGEEF
TMHDTIGCYL DIDKGHVKFS KNGKDLGLAF EIPPHMKNQA LFPACVLKNA ELKFNFGEEE
FKFPPKDGFV ALSKASDSYV VKSQHTGNAQ VAQTKFLPNA PKALIVEPSR ELAEQTLNNV
KQFKKYIDNP KLRELLIIGG VAARDQLSVL DNGVDIVVGT PGRLDDLVST GKLNLSQVRF
LVLDEADGLL SQGYSDFINR IHNQIPQITS DGKRLQVIVC SATLHSFDVK KLSEKIMHFP
TWVDLKGEDS VPDTVHHVVV PVNPRTDRLW ERLGKNHIRT DDVHAKDNTR PGANSPEMWS
EAIKILKGEY AVRAIKEHKM DQAIIFCRTK IDCDNLEQYF MQQGGGPDKK GHQFSCVCLH
GDRKPHERKQ NLERFKKGDV RFLICTDVAA RGIDIHGVPY VINVTLPDEK QNYVHRIGRV
GRAERMGLAI SLVATEKEKV WYHVCSSRGK GCYNTRLKED GGCTIWYNEM QLLSEIEEHL
NCTISQVEPD IKVPVDEFDG KVTYGQKRAA GGGNYKGHVD ILAPTVQELA ALEKEAQTSF
LHLGYLPNQL FRTF
//
