ID A0A384CVT7_URSMA Unreviewed; 333 AA.
AC A0A384CVT7;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=T-cell surface glycoprotein CD1b-like {ECO:0000313|Ensembl:ENSUMAP00000005479, ECO:0000313|RefSeq:XP_040491819.1};
GN Name=CD1B {ECO:0000313|Ensembl:ENSUMAP00000005479};
GN Synonyms=LOC103672077 {ECO:0000313|RefSeq:XP_040491819.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Ensembl:ENSUMAP00000005479};
RN [1] {ECO:0000313|Ensembl:ENSUMAP00000005479}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_040491819.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_040491819.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Antigen-presenting protein that binds self and non-self lipid
CC and glycolipid antigens and presents them to T-cell receptors on
CC natural killer T-cells. {ECO:0000256|ARBA:ARBA00037203}.
CC -!- SUBUNIT: Heterodimer with B2M (beta-2-microglobulin). Interacts with
CC saposin C. {ECO:0000256|ARBA:ARBA00038793}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
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DR RefSeq; XP_008698962.1; XM_008700740.1.
DR RefSeq; XP_008698963.1; XM_008700741.1.
DR RefSeq; XP_040491819.1; XM_040635885.1.
DR STRING; 29073.ENSUMAP00000005479; -.
DR Ensembl; ENSUMAT00000006608.1; ENSUMAP00000005479.1; ENSUMAG00000004332.1.
DR KEGG; umr:103672077; -.
DR OMA; VLPNANW; -.
DR OrthoDB; 4632172at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd21029; IgC1_CD1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011161; MHC_I-like_Ag-recog.
DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR PANTHER; PTHR16675; MHC CLASS I-RELATED; 1.
DR PANTHER; PTHR16675:SF130; T-CELL SURFACE GLYCOPROTEIN CD1B; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF16497; MHC_I_3; 1.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 4: Predicted;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..333
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041164342"
FT TRANSMEM 299..324
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 185..285
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 333 AA; 36495 MW; 6E303EFB3CD89892 CRC64;
MLLLLLALPA VLCPGGGGEE AFQGPTSYHA IQISSFINSS WAQTQGSGWL GDVQIHGWDS
AANRAVFLKP WSKGNFSDEE VTELEELIQV YLNGFVLEVQ DHASEFQMEY PFEIQGIAGC
KLHSGGGTVS FLRGALGGLD FLSLKNYSCV PAPEGGSRAQ HICELLSQYK GIQDIGEKLL
FETCPRYLLG VLDAGKAELQ RQVKPEAWLS AGPSPGPGHL LLVCHVSGFY PKPVWVMWMR
GEQEQPGTQR GDVLPHADGT WYLRVTLDVA AWEAAGLSCR VRHSSLGGQD MVLYWGNPIS
IGLILLAIIV PFLILLIGLL LWFLKRWSYQ SIS
//
