ID A0A384CWA3_URSMA Unreviewed; 6301 AA.
AC A0A384CWA3;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 03-AUG-2022, sequence version 2.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Adhesion G-protein coupled receptor V1 {ECO:0000313|RefSeq:XP_008699058.2};
GN Name=ADGRV1 {ECO:0000313|RefSeq:XP_008699058.2};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008699058.2};
RN [1] {ECO:0000313|RefSeq:XP_008699058.2}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008699058.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_008699058.2; XM_008700836.2.
DR STRING; 29073.ENSUMAP00000006949; -.
DR KEGG; umr:103672164; -.
DR OrthoDB; 2912542at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.60.40.2030; -; 34.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR026919; ADGRV1.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR009039; EAR.
DR InterPro; IPR005492; EPTP.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR006558; LamG-like.
DR PANTHER; PTHR46682; ADHESION G-PROTEIN COUPLED RECEPTOR V1; 1.
DR PANTHER; PTHR46682:SF1; ADHESION G-PROTEIN COUPLED RECEPTOR V1; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF03160; Calx-beta; 33.
DR Pfam; PF03736; EPTP; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR SMART; SM00237; Calx_beta; 17.
DR SMART; SM00560; LamGL; 1.
DR SUPFAM; SSF141072; CalX-like; 37.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS50912; EAR; 6.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_008699058.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..6301
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5035426801"
FT TRANSMEM 5903..5923
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5935..5954
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5974..5994
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 6006..6031
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 6051..6075
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 6102..6119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 6125..6150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 3247..3288
FT /note="EAR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00075"
FT REPEAT 3289..3337
FT /note="EAR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00075"
FT REPEAT 3340..3385
FT /note="EAR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00075"
FT REPEAT 3387..3431
FT /note="EAR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00075"
FT REPEAT 3433..3480
FT /note="EAR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00075"
FT REPEAT 3484..3526
FT /note="EAR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00075"
FT DOMAIN 5900..6151
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 6212..6243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6267..6286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6212..6239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6267..6285
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 6301 AA; 690857 MW; 15C0DA4D18EEFC86 CRC64;
MPSASLLVNL LTALFIPFVF GETEIRFAGQ TKFVVNETST TVIRLVIERI GEPANVTAIV
SLYGDDTGDF FDTYAAAFIP VGETNRTVYI AVCDDDLPEP DETFIFHLTL QKPSANVKLG
WPRTVTVTIL SNDNAFGIIS FNMPFSITVR EPRGRNESVP LTLIREKGTY GMVTVTFEVE
GGPNPPEEDL SPVKGNITFP PGRATVVYNL TVLDDEVPEN DEIFLIQLKS VEGGAEINTS
RSSVEIIIKK NDSPVRFIQN VYLVPEEDHI LLIPVVRGKD DNGHLIGSDE YEVSISYVII
TGNSTAHAQQ NLDFIDLQAT PTIVFPPFIH ESHLKFQIVD DTIPEIAESF HVVLLKDTLQ
GDAVLLGPSI VQITIKPNDK PYGVLSFNSI LFERIVVIDE DTTSRFEEVT VVRNGGTHGN
ISVNWELTRN SSDPTPVTAD IRPSSGVLYF AQGQMLASIP LTIVNDDLPE EAEAYLLRIL
PHTVRGGAEV SEPAELLFYI QDSDDVYGLI TFFPMENQKI ESSPGERYLF LSFTRQGGTK
GDVKMFYSAL YIPPGAVDPL RAKDGILNMS RRNNLIFPEQ KIQVTTKLPI RNDAFLQNGA
HFLVKLETVE LVNIIPPIPS ISPRFGEIQN ISLVVTPDIA NGEIGFISNL PVVLHEPEDS
AAEVVYIPLH RDGTDGQATV YWSLKPSGFN SKAVTLDDIG PFNGSVVFLS GQSDTTINIT
VKADDTPEMN ETVALSLDRI NVENQVLKSG YTSRDLIILE NDDPGGIFEF SPTSRGPYVI
KEGESVELHI TRSRGALVKQ FLRYQVEPRD SNEFYGNTGV LEFKPGEREI VITLLTRLDG
IPELDEHYWV VLSSHGERES KLGSATVVNI TILKNDDPHG IIEFVSDDLI VMINESKGDD
TYSAVYDVIR NRGTFGDVSV SWVVSPDVTQ DVFPVQGAIF FGYQEFSKNI TIYSLPDEIP
EEMEEFTITL FNATGGAKIG NKTTATLRIR RNDDPIYFAE PRVVRVQEGE TANVTVLRNG
SVDVACTVQY ATLDGKATAR DGDFVPVEKG EALVFAVGSR KQRISVFINE DDIPETDEPF
YIILFNSTGD TVVYQYGIAT VIIEANDDPN GIFSLEPIDK AVEEGKTNAF WILRHRGHFG
NVSVAWQLFQ NDSALQPGQE FYETSGIFNF MDGEEAKPII LHAFPDKIPE FNEFYILKLV
NISGGSPGPG GQLAGTNLQV TVMIPLNDDP FGVFILDPEC LEREVAEDVL SEDDMSYITN
FTILRQQGVF GDVRVGWEIL SSDFTDGLPP VIDFLLVGVF PSTVHLQPHM RRHHSGTAAL
YFSGLEGAFG TVNPKYHPSR NNSIANFTFS AWVMPNADTN GFVIAKDDGN GSIYYGIKIQ
TNESHVSLSL HYKTLGSNAT YIAKTTVTKY LEENVWLHLL IILDDGIIEF YLDGNAMPRG
IKSLKGEAIT DGPGTLRIGA GMNGNDRFTG LMQDVRAYER KLTLEEIYEL HAMPAKSDLH
PVSGYLEFRQ GETNKSFIIS ARDDNEEEGE ELFILKLVSV YGGACISEEN TTARLIIQKS
DNANGLFGFT GACIPEIAEE GSTVSCVVER TRGALDYVHV FYTISQIESE GINYLVDDFA
NASGTITFLP WQRSEVLNIY VLDDDIPELN EYFRVTLVSA VPGDGKLGST PTSGASIDPE
KETTDITIKA SDHPYGLLQF STGLPPEPED TMTLPASSIP HVIVQEEDGE VRLLVVRAQG
LLGRVLAEFR TVPLTAFSPE DYQSVAGTLE FQPGERYKYI SVNITDNTVP ELEKSFKVEL
LNLEGGVTEF FRVDGSGSGD GDMEFFLPTI HKHASLGVAS QILVTIAASD HAHGIFEFSP
ESLFVSGTEP EDGYSTVTLN IMRSHGALSQ VTLLWSIGSD PDGDLAFTSG NVTFEIGQKS
ANITVEVLPD EDPELDKAFS LSILSVSSGS LGVHTNATLT VLASDDPCGV FIFSEKNRPI
KVEEATQNIT LSVIRLKGLM GKVLVTYATL DDMEKPPYFP PSIARATQGR DYIPASGFAL
FRANQSEATI TISVLDDDEP ERSESLFIEL LNSTLIEKVQ NRPIPNSPRL GPKVETIAHL
IITANDDAFG TLQLSAPVVR VAENHVGPII NVTRAGGAFA DVSVKFKAVP ITAVAGEDYS
IASSDVVLLE GETSKAVPIY IINDIYPELE ESFLVQLLNE TTGGAKLGAL TEAIIIIEAS
DDPYGLFGFQ ITKLIVEEPE FNSVKVNLPI IRNSGTLGNV TVQWVATING QLATGDLRVV
SGNVTFAPGE TIQTLLLEVL ADDVPEIEEV IQVQLTDASG GGTLGLDRVA SIIIPANDNP
YGTVAFVQSV YRVQEPLERS SCANITVRRS GGHFGQLLLF YSTSDIDVVA LAVEEGQDLL
SYYESPIQGV PDPPWRTWVN VSAMEEPQYT CATLCLKEHA CSAFSFLSAT EGPQCFWMTS
WISPVVNNLD FWTYRKNMTR VASLFSGQAV AGSDYEPVTR QWAIMLEGDE FANLTVSILP
DDFPEMDESF LISLLEVHLM NITASFKNQP TIGQPNTSTV VIALNGDAFG VFVVYSISPN
TSEDGLYVEV QEQPQTTVEL VIYRTGGSLG QVTVEWRVVG GTATEGLDFI GAGDILTFAE
GETKKTAILA IVDDSEPEDD ESIIVSLVYT EGGSRILPSS DTVRVNILAN DNVAGIVSFQ
TASRSVIGHE GEILQFHVVR TPPGRGNVSV NWKIIGQNLE LNFANSTGQL FFPEGILNKT
VLVHLLDDNI PEEKEVYQVI LYDVRTQGVP PAGIALLDAQ GYAAVLTVEA SDEPHGVLNF
ALSSRFVLLQ EANITIQLFI NREFGSLGTI NVTYSTVPGM LSLKNQTEGN LAEPDVDFVS
VVGFLILEEG ETAATINITI LEDDIPELEE YFLVNLTYVD LIMAPLTSFP PRLDSEGLTA
QIIIDANDGA RGMIEWQHSK FEVNETKGSL TLVAQRSKGA LGHVSLFVYA QNLEAQLGLD
YIFTPMILHF VDGERSKNID IMILDDDIPE GDETFQLILT NPSPGLELGE KTTALISILA
NDDGPGVLSF NNSEHFFLRE PTALYVQESV AVLYIVREPA QGLFGTVTVQ FIVTEINSSM
ESKDLTPSKG YVVLEEGVRF KALRISAILD TEPEMDEHFV CTLFNPTGGA RLGAHVQTLI
TVLQNQAPLG LFSISAVANR ATSIDIEEAN RTVYLNVSRT NGIDLAVSVE WETISETAFG
MRGMDAVFST VQSFLHASAS GWCFFTLEDS IYGVMLRKLS STVYRWQGIF IPLEDLNIEN
PKTCEAFNIG HSPYFVITHE ERSDEKPSVN SVYTFTSGFK LFLVQTIIIS ESSQVKYFSS
DNQDYLIVAS QREDSELTQV FRWSGGSFTS HQTLPVRGVL SIALFTRGSS VFLAISQINA
RPNSLLLRWS GSEFINFQEV PINGTTQVEA LTSGDDIYLI FAKTVFLGNQ NSIDIFIWET
GQSSFRYFQS LDFAAVNRIY SFTPASGIVH ILLIGQAMST LYCWNSELNQ FSSILEAPSA
RDAASVTVKS FNSSKSLIAL VGAVHSHVYE LAYISSQSDF IPSSGELIFE PGDREAVIVV
NILDDTVPEE EESFRVQLKN PKGGAEIGIN GYVKITILSN DDAYGVVGFA QNSLYKQVEE
MEQDSLLTLN VERLKGTYGR ITVMWEADGS ISDIFPTSGV ISFSEGQALS TITLTVLADD
VPELSEIVSI TLIRITTEGV EDPSKGATID QKRNKSVITT LSNDSPYGLV GWHSEFLFVR
VAEPKANTTI LQLPIVRDRG LFGAIAIHLI AKPNFLLHVD NQATANEDYV LQETIIIMKE
NIKETHIKVA ILPDNAPELE EGFIVNITDV YLVNSDFSTE QPSVRRPGIE IVEIMIEEND
DPRGIFEFHV TRDIGGVITA YEVPSPLNVL QVPVVRLAGS FGTVSVYWKA TVDTAGLEDF
KPSHGILEFA DKQVAAMIEM TIIDDAELEL METFNISLIR VAGGGRLGDD VVLTVVIPQN
DSPFGVFGFE EKTVMVDESL LSDDPDSYVT LTVVRSPGGK GAVRLQWTID ETAKDDLRPL
NGTLLFDETE SQKTIILHAL HDTVLEEDRH FTIQLISLDE VEISPMKGSA SIIIRGEKGT
SGEVGIAPSS RHVLIGEPSG KYNGTAIISL VRGPAIWGEI TVYWSIVPPS VGEFAEISGK
LTMRDGQSAA VVIIQALNDD IPEEKSFYEF QLTGISEGGL LSGSSSTANI TMVASDFPYG
RFSFSQEHLR VSEEAQRVNI TVLRSGGSFG PVRLWYETVS GTAEAGLDFI PAAGEILFEA
REMAKSVHIE ILDDGLPEGP EEFSLVITKV ELRGRGYDFT IRENGLQLDQ PPEIGNISVV
RIIIMKNDNA EGVIEFEPRH TAFEVEEDAG MIMIPVVRLH GAYGRVTADF ISQSSSAVAG
GVDYILHGSS VTFQHGQNLS FINISIVDDS ESEFAEPIEI LLVGATGGAV LGRHLVSRIT
VAKSDSPFGV VRFLNQSRIS LPNPNSTMIL SLLLERTGGL LGEIQVNWVI LGPNSQEALP
PQNTDIADPV SGSFYFGEGE GGVRAITLIV YPHEDIEVEE IFIIKLELGK GEAKLDSRAK
DITLTIQKFG DPNGVVHFAP ESLSEKTYSE PLALEGPLVI TFFVKRVKGI FGEITVYWEI
SSEFDITGDF LSTKGFFTIA DGESEVSFDV YLLPDDIPEI EEDFVIRLVS VEGGAELDPE
KCTTRFSVSA NDDPHGVFAL YSDYQSIFIG QNLSRFIQIN VTRLAGTFGD VAVGFRISSD
QKEPPVVTEN VERQLVVKDG ARYKVDVVPV RSQVFLSLGS NFTLQLVTAM LVSGRFYDMP
KILQEAKSAV LPVPEKAANS QVGFESTAFA LTDITAGTSQ VVISRRGTYG SLMVAWVAGY
APGLEVPEFL VVGNMTPKLG SLSFSHGEQR KGVLLWTFPS PGRPEAFVLH LSGVQSSAPG
GAQLRSGFTF AEIEPMGVFQ FSPSSRNVMV SEDTQMIRLY VQRLFGFHGD LVKVSYQTAA
GSAKPVEDFE PVQNGDLLFQ KFQPEVDFEI IIINDQLPEE EEIFYVNLTS VEMKGLQKFD
ADWRPRLNQD FSVALITILD NDDPAGMDVS FPKTTVAVAV DTALIPVETD FSTIYPDTTK
MTAVPQPTEM VAIITEATGV SAIPEKLVTV PDTSALSEKP DLATVTANVS VHGVFSLGPP
IVYVEEEVKN GTFNAAEILI RRTGGSTGNV TITVKTFGER SAQKEPNALP FHDISGISNL
TWATEEEDFE EHTLILTFID GERERQVLVQ ILDDEEPEGQ ELFYVFLTDP QGGAQIVKGK
DDSGFAAFAR IIITGSDLHN GIIGFSEESQ SGLELGEGAD KSRLHLTVTR QPNRAFEDVK
VFWRVTFNKT AAMLEKDGVN LMDELLSVSG TTTCTVGQTK CIITIELKPG KVPPTEMPFF
VELYEVSAGA AINHSARFAP IQFLQTAGPQ SLVYFSVGSR LPVAHKKATL ISLQVARDSG
TGLMMSVNFS TQELRSAETV GRTLISPALS GKDFVRTEGT LVFEPGQRNT ILDVILTPET
GSLNPFPKRF QIVLFDPKGG ARIDQMYGTA NITLVSDADS QSFWGLADQL QQPLDGDILN
RVLHSISMKV ATESTDEQLS AVMHLIDKIT VEGKSRAFSI ENRSLFYEIL CALTNPKRKD
TRGFSHFTEV TENFAFSLLT GVTCGSPGEK SKTILDSCPY LSILALHWYP QQINGHKFEG
KEGDYIRVPA RLLEVPEAEI MAGKSTCKLV QFTEYSSQQW FITGNNLHAL KNKVLSLSVK
GQRSQPLTDN NEVLYRIYAA EPRIIPQTSL CLLWNQAAAS WLSDSQFCKV VEDTADYVEC
ACSYMSAYAV YAQTDSLSSY NEAFFSSGFI CVSGLCLAVL SHVFCARYSM FAAKLLTHMM
AASLGTQVVF LVSAYASPQL TDESCSAVAA VTHYLYLCQF SWMLIQSVNF WYVLVMNDEH
TERRYLLFFL LSWGLPAFVV ILLIVILRGI YHQSMPQIYG LIHGDLCFIP NIYAALFTAA
LVPLMCLVVV FVVFIHAYQV KPQWKAYDDV FRGRTNAAEI PLVLYLFGLI SVTWLWGGLH
MAYRHFWMLV LFVIFNSLQG LYVFVVYFIL HNQTCCPMKA SYTVEMNGHP GPSTAFFTPG
SGMPPAGGEI SKSTQNLISA MEEVPPDWER ASFQQASQAS PDLKPSPQNG ATFPSSGGYG
QGSLIADEES QEFDDLIFAL KTGAGLSVSD NESGQGSQEG GTLTDSQIVE LRRIPIADTH
L
//
