ID   A0A384CX61_URSMA        Unreviewed;       344 AA.
AC   A0A384CX61;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   03-AUG-2022, sequence version 2.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=glutathione transferase {ECO:0000256|ARBA:ARBA00012452};
DE            EC=2.5.1.18 {ECO:0000256|ARBA:ARBA00012452};
DE   AltName: Full=GST class-pi {ECO:0000256|ARBA:ARBA00032759};
GN   Name=LOC103672175 {ECO:0000313|RefSeq:XP_008699074.2};
OS   Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008699074.2};
RN   [1] {ECO:0000313|RefSeq:XP_008699074.2}
RP   IDENTIFICATION.
RC   TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008699074.2};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the GST superfamily. Pi family.
CC       {ECO:0000256|ARBA:ARBA00007297}.
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DR   RefSeq; XP_008699074.2; XM_008700852.2.
DR   AlphaFoldDB; A0A384CX61; -.
DR   STRING; 29073.ENSUMAP00000005813; -.
DR   KEGG; umr:103672175; -.
DR   OrthoDB; 5546594at2759; -.
DR   Proteomes; UP000261680; Unplaced.
DR   GO; GO:0004364; F:glutathione transferase activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.20.1050.10; -; 1.
DR   Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR   InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR004045; Glutathione_S-Trfase_N.
DR   InterPro; IPR004046; GST_C.
DR   InterPro; IPR003082; GST_pi.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR11571; GLUTATHIONE S-TRANSFERASE; 1.
DR   PANTHER; PTHR11571:SF141; GLUTATHIONE S-TRANSFERASE P; 1.
DR   Pfam; PF00043; GST_C; 1.
DR   PRINTS; PR01268; GSTRNSFRASEP.
DR   SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR   SUPFAM; SSF52833; Thioredoxin-like; 1.
DR   PROSITE; PS50405; GST_CTER; 1.
DR   PROSITE; PS50404; GST_NTER; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000261680}.
FT   DOMAIN          127..182
FT                   /note="GST N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50404"
FT   DOMAIN          184..313
FT                   /note="GST C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50405"
SQ   SEQUENCE   344 AA;  38981 MW;  467C939172770AA8 CRC64;
     MLELIQDDGH WEDTLSSRRI STPSHKAVIS RREPENLKDF PPLAMPYLNT IIQVGTVKPP
     SQLPEERRQR KLSEALLKAQ CFGDLSHHHR RRHQPRHPHC NRGALCRCPL SAGESRGAMP
     VLPTGRGQSW KEEVVTVETW PQGSLKTSCL YGQLLKFWDR DLTLYHSNAI LRHLGRSLGP
     FRRDRWEAAL VAAVSDGVEN LCVKYIILIY TNYEAGKEEY VKALPGHLKP FETLLSQNQR
     GQAFITGNTI SSADCNLLDL PLIHQVLKPP APGSLDSFPL FSAYLVLLRF WPRLKAFLAF
     PKAVDLASIP TRISESLWHP LQEVGAACVP FPRTNKISKR EKKR
//