ID A0A384CXF0_URSMA Unreviewed; 560 AA.
AC A0A384CXF0;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Coenzyme A synthase {ECO:0000313|Ensembl:ENSUMAP00000034780, ECO:0000313|RefSeq:XP_008699517.1};
GN Name=COASY {ECO:0000313|Ensembl:ENSUMAP00000034780,
GN ECO:0000313|RefSeq:XP_008699517.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008699517.1};
RN [1] {ECO:0000313|Ensembl:ENSUMAP00000034780}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008699517.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008699517.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_008699517.1; XM_008701295.2.
DR STRING; 29073.ENSUMAP00000034780; -.
DR Ensembl; ENSUMAT00000041145.1; ENSUMAP00000034780.1; ENSUMAG00000025044.1.
DR GeneID; 103672577; -.
DR CTD; 80347; -.
DR OMA; TQCLQSY; -.
DR OrthoDB; 460288at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:Ensembl.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004140; F:dephospho-CoA kinase activity; IEA:Ensembl.
DR GO; GO:0004595; F:pantetheine-phosphate adenylyltransferase activity; IEA:Ensembl.
DR GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:Ensembl.
DR CDD; cd02022; DPCK; 1.
DR CDD; cd02164; PPAT_CoAS; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00376; Dephospho_CoA_kinase; 1.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR001977; Depp_CoAkinase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR NCBIfam; TIGR00152; dephospho-CoA kinase; 1.
DR PANTHER; PTHR10695:SF64; BIFUNCTIONAL COENZYME A SYNTHASE; 1.
DR PANTHER; PTHR10695; DEPHOSPHO-COA KINASE-RELATED; 1.
DR Pfam; PF01121; CoaE; 1.
DR Pfam; PF01467; CTP_transf_like; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51219; DPCK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..560
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041072383"
FT DOMAIN 196..339
FT /note="Cytidyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF01467"
SQ SEQUENCE 560 AA; 61486 MW; B4DFB904AD77342C CRC64;
MAVFRSGLLV LTTPLASLAP RLAPILTSAA RLVNHTLYVH LQPGMSLGGP AQPQSSLVQA
TFEVLDFITH LYAGADVHRH LDVRVLLTNI GAKSAFLPPL PSSVQNLAHP PEVVLTDFQT
LDGSQYNPVK QQLERYATSC YSCCPQLASV LLYPDYGPGE LPVESLDVPL PSTIRPASPV
ARSPKQPVRG YHRGAVGGTF DRLHNAHKVL LSVACILAQE QLVVGVADKD LLKSKLLPEL
LQPYAERVDH LSEFLVDIKP SLTFDIIPLL DPYGPAGSDP SLEFLVVSEE TYRGGMAVNR
FRLENDLEEL ALYQIQLLKD QSHKENEEDK VSSSSFRQRM LGTLLRPPYK RPELPAQLYV
IGLTGISGSG KSSVAQRLKG LGAYVIDSDQ LGHRAYAPGG PAYQPVVEAF GTDILHKDGI
INRKVLGSRV FGNKKQLKIL TDIVWPVIAK LAREEMAQAM AEGKHVCVVD AAMLLEAGWQ
NMVHEVWTVV IPETEAIRRI MERDGLSEAA AQSRLQSQMS GQQLVDQSHV VLSTLWEPHV
TQGQVEKAWA LLQKRMPQSP
//
