ID A0A384CXJ6_URSMA Unreviewed; 567 AA.
AC A0A384CXJ6;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Bifunctional coenzyme A synthase isoform X1 {ECO:0000313|RefSeq:XP_008699516.1, ECO:0000313|RefSeq:XP_040496523.1};
GN Name=COASY {ECO:0000313|RefSeq:XP_008699516.1,
GN ECO:0000313|RefSeq:XP_040496523.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008699516.1};
RN [1] {ECO:0000313|RefSeq:XP_008699516.1, ECO:0000313|RefSeq:XP_040496523.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008699516.1,
RC ECO:0000313|RefSeq:XP_040496523.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_008699516.1; XM_008701294.2.
DR RefSeq; XP_040496523.1; XM_040640589.1.
DR GeneID; 103672577; -.
DR KEGG; umr:103672577; -.
DR CTD; 80347; -.
DR OrthoDB; 460288at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004140; F:dephospho-CoA kinase activity; IEA:InterPro.
DR GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:InterPro.
DR CDD; cd02022; DPCK; 1.
DR CDD; cd02164; PPAT_CoAS; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00376; Dephospho_CoA_kinase; 1.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR001977; Depp_CoAkinase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR NCBIfam; TIGR00152; dephospho-CoA kinase; 1.
DR PANTHER; PTHR10695:SF64; BIFUNCTIONAL COENZYME A SYNTHASE; 1.
DR PANTHER; PTHR10695; DEPHOSPHO-COA KINASE-RELATED; 1.
DR Pfam; PF01121; CoaE; 1.
DR Pfam; PF01467; CTP_transf_like; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51219; DPCK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..567
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041072370"
FT DOMAIN 196..339
FT /note="Cytidyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF01467"
SQ SEQUENCE 567 AA; 62218 MW; 46942954AC210FC9 CRC64;
MAVFRSGLLV LTTPLASLAP RLAPILTSAA RLVNHTLYVH LQPGMSLGGP AQPQSSLVQA
TFEVLDFITH LYAGADVHRH LDVRVLLTNI GAKSAFLPPL PSSVQNLAHP PEVVLTDFQT
LDGSQYNPVK QQLERYATSC YSCCPQLASV LLYPDYGPGE LPVESLDVPL PSTIRPASPV
ARSPKQPVRG YHRGAVGGTF DRLHNAHKVL LSVACILAQE QLVVGVADKD LLKSKLLPEL
LQPYAERVDH LSEFLVDIKP SLTFDIIPLL DPYGPAGSDP SLEFLVVSEE TYRGGMAVNR
FRLENDLEEL ALYQIQLLKD QSHKENEEDK VSSSSFRQRM LGTLLRPPYK RPELPAQLYV
IGLTGISGSG KSSVAQRLKG LGAYVIDSDQ LGHRAYAPGG PAYQPVVEAF GTVLCLCCPD
ILHKDGIINR KVLGSRVFGN KKQLKILTDI VWPVIAKLAR EEMAQAMAEG KHVCVVDAAM
LLEAGWQNMV HEVWTVVIPE TEAIRRIMER DGLSEAAAQS RLQSQMSGQQ LVDQSHVVLS
TLWEPHVTQG QVEKAWALLQ KRMPQSP
//
