ID A0A384CYU0_URSMA Unreviewed; 456 AA.
AC A0A384CYU0;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Lipase I {ECO:0000313|Ensembl:ENSUMAP00000018480};
DE SubName: Full=Lipase member I isoform X1 {ECO:0000313|RefSeq:XP_008699956.1};
GN Name=LIPI {ECO:0000313|Ensembl:ENSUMAP00000018480,
GN ECO:0000313|RefSeq:XP_008699956.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008699956.1};
RN [1] {ECO:0000313|Ensembl:ENSUMAP00000018480}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008699956.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008699956.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000256|ARBA:ARBA00010701, ECO:0000256|RuleBase:RU004262}.
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DR RefSeq; XP_008699956.1; XM_008701734.2.
DR STRING; 29073.ENSUMAP00000018480; -.
DR ESTHER; ursma-a0a384cyu0; Phospholipase.
DR Ensembl; ENSUMAT00000021869.1; ENSUMAP00000018480.1; ENSUMAG00000013574.1.
DR GeneID; 103673036; -.
DR KEGG; umr:103673036; -.
DR CTD; 149998; -.
DR OMA; CAYYFVL; -.
DR OrthoDB; 3428256at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:InterPro.
DR GO; GO:0008201; F:heparin binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004620; F:phospholipase activity; IEA:Ensembl.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR CDD; cd00707; Pancreat_lipase_like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR013818; Lipase.
DR InterPro; IPR016272; Lipase_LIPH.
DR InterPro; IPR033906; Lipase_N.
DR InterPro; IPR000734; TAG_lipase.
DR PANTHER; PTHR11610; LIPASE; 1.
DR PANTHER; PTHR11610:SF103; LIPASE MEMBER I; 1.
DR Pfam; PF00151; Lipase; 1.
DR PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 1.
DR PRINTS; PR00821; TAGLIPASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PIRSR:PIRSR000865-2};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000865-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 40..330
FT /note="Lipase"
FT /evidence="ECO:0000259|Pfam:PF00151"
FT ACT_SITE 159
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT ACT_SITE 183
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT ACT_SITE 253
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-1"
FT BINDING 197
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
FT BINDING 199
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
FT BINDING 202
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000865-2"
SQ SEQUENCE 456 AA; 51948 MW; C0E9420ECB2206BB CRC64;
MRVYIFLCLM CWARSENKRL CLEFSQLSIK DSFKDLFVPQ TEIFLMLYTR NNLNCAEPLF
EQSNSLNVNF NISKKTVWLI HGYRPTGSAP SWLQRFLRIL LNQDDINIIV VDWNRGATTF
LYNRAVKNTR KVAMSLSGYI RNLLKHGASL DNFHFIGISL GAHISGFVGK IFQGQLGRIT
GLDPAGPKFS GKSFNDRLDY TDAKFVDVIH SDTNGLGIKE PLGHIDFYPN GGKTQPGCPK
SILSGIRFIK CDHQRAVYLF MASLETNCNF ISFPCPSYED FKAGSCVDCD KFSEKSCPRL
GYQAELWKDV LKVRREETTV FLDTAGTSPF CAYYFVLTVT VLDDTLEDGY ITFKLLNQLG
MVEEPRLYEK NRSFNELQEV KILAQFLNDV VNISSIGLAY SQGSNLQCFT GRYNIQRIML
QSLTYPERPP LCIYNFVLKE DEEVFLSPST CTSKKI
//
