UniProt: A0A384D115

Database: UniProt
Entry: A0A384D115_URSMA

LinkDB:  A0A384D115_URSMA 
Original site:  A0A384D115_URSMA

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Ontology (3)   
   GO (3)   
Gene (1)   
   KEGG GENES (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (11)   
   InterPro (6)   
   Pfam (2)   
   PROSITE (2)   
   SMART (1)   
All databases (16)   

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ID   A0A384D115_URSMA        Unreviewed;       783 AA.
AC   A0A384D115;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   03-AUG-2022, sequence version 2.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Cadherin-5 {ECO:0000256|ARBA:ARBA00021701};
DE   AltName: Full=Vascular endothelial cadherin {ECO:0000256|ARBA:ARBA00030559};
GN   Name=CDH5 {ECO:0000313|RefSeq:XP_008700743.2};
OS   Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008700743.2};
RN   [1] {ECO:0000313|RefSeq:XP_008700743.2}
RP   IDENTIFICATION.
RC   TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008700743.2};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC       {ECO:0000256|RuleBase:RU004357}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC       ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004479}.
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DR   RefSeq; XP_008700743.2; XM_008702521.2.
DR   STRING; 29073.ENSUMAP00000029128; -.
DR   KEGG; umr:103673688; -.
DR   OrthoDB; 3667774at2759; -.
DR   Proteomes; UP000261680; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   CDD; cd11304; Cadherin_repeat; 5.
DR   Gene3D; 2.60.40.60; Cadherins; 5.
DR   Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR   InterPro; IPR039808; Cadherin.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR000233; Cadherin_Y-type_LIR.
DR   InterPro; IPR027397; Catenin-bd_sf.
DR   PANTHER; PTHR24027; CADHERIN-23; 1.
DR   PANTHER; PTHR24027:SF89; CADHERIN-5; 1.
DR   Pfam; PF01049; CADH_Y-type_LIR; 1.
DR   Pfam; PF00028; Cadherin; 5.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 5.
DR   SUPFAM; SSF49313; Cadherin-like; 5.
DR   PROSITE; PS00232; CADHERIN_1; 2.
DR   PROSITE; PS50268; CADHERIN_2; 5.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00043};
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW   ECO:0000256|RuleBase:RU003318};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003318};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           17..783
FT                   /note="Cadherin-5"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5035476390"
FT   TRANSMEM        599..619
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          78..148
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          149..255
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          256..370
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          371..477
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          477..584
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
SQ   SEQUENCE   783 AA;  87781 MW;  6D242BE7CF253B67 CRC64;
     MQVLVLLLAS VGTCLGLLVA AAAGTTPARP DPPSVLPIHR RQKRDWIWNQ MHIDEEKNTS
     LPHYVGKIKS SVNRKNAKYV LKGESVGKVF RVREDTGDVY AFERLDREKI PEYHLTALVV
     DKNTNKNLES PSSFTIKVHD VNDNWPVFTH RLFNASVPEM SAVGTSVIRV TAVDADDPTV
     ADHASVMYQI LKGEEYFAID GSGLIFTTTK TLDREMQAKY EIVVEARDAQ GLRGESGTAT
     VLVTLQDIND NFPIFTQPKY TFAVPEDIRV GSSLGSLFVE DPDEPQNRMT KYSIVQGEYR
     DTFTIETDPN HNEGIIKPMK PLDYEYIQQY IFTIEATDPT INLHYLSSVS IRKTARVIIN
     VTDVDEPPNF KQSFYHFQLR ENQKKPLIGS VLATDPDAAR RSIGYSIRKT SDKGQFFRIT
     KQGNIYNEKE LDREIYPWYN LTVEAKELDS SGYPTGKESI VQVHIEIMDE NDNPPEFAQP
     YEPRVCENAA QGKLVVQISA IDKDITPRDV KFKFSLTTED SNFTLTDNHD NTANITVKYG
     QFDRERAKVH HLPVLISDNG RPSLTGTSTL VVTICKCNEH GEFTHCEEMA GQAGVSIQAL
     VAIFLCILTI TVITLLIFLR RRLRKQARAH GKSVPEIHEQ LVTYDEEGGG EMDTTSYDVS
     VLNSVRHGGS KPPRPALEAR PSVYAQVQKP PRHAPAVHGG PGEMAAMIEV KKDEADHDGG
     GPPYDTLHIY GYEGAESIAE SLSSLGTDSS DSDIDYDFLN DWGPRFKMLA ELYRSDPQEE
     LLY
//

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