ID A0A384D196_URSMA Unreviewed; 93 AA.
AC A0A384D196;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=C-C motif chemokine {ECO:0000256|RuleBase:RU361150};
GN Name=CCL22 {ECO:0000313|Ensembl:ENSUMAP00000029999,
GN ECO:0000313|RefSeq:XP_008700823.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008700823.1};
RN [1] {ECO:0000313|Ensembl:ENSUMAP00000029999}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008700823.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008700823.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU361150}.
CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC {ECO:0000256|ARBA:ARBA00010868, ECO:0000256|RuleBase:RU361150}.
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DR RefSeq; XP_008700823.1; XM_008702601.2.
DR STRING; 29073.ENSUMAP00000029999; -.
DR Ensembl; ENSUMAT00000035441.1; ENSUMAP00000029999.1; ENSUMAG00000021694.1.
DR GeneID; 103673763; -.
DR CTD; 6367; -.
DR OMA; RDYIRHP; -.
DR OrthoDB; 4265193at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0008009; F:chemokine activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR CDD; cd00272; Chemokine_CC; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR000827; Chemokine_CC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015:SF102; C-C MOTIF CHEMOKINE 22; 1.
DR PANTHER; PTHR12015; SMALL INDUCIBLE CYTOKINE A; 1.
DR Pfam; PF00048; IL8; 1.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; Interleukin 8-like chemokines; 1.
DR PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE 3: Inferred from homology;
KW Chemotaxis {ECO:0000256|ARBA:ARBA00022500, ECO:0000256|RuleBase:RU361150};
KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|RuleBase:RU361150};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Secreted {ECO:0000256|RuleBase:RU361150};
KW Signal {ECO:0000256|RuleBase:RU361150}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|RuleBase:RU361150"
FT CHAIN 25..93
FT /note="C-C motif chemokine"
FT /evidence="ECO:0000256|RuleBase:RU361150"
FT /id="PRO_5041477934"
FT DOMAIN 33..91
FT /note="Chemokine interleukin-8-like"
FT /evidence="ECO:0000259|SMART:SM00199"
SQ SEQUENCE 93 AA; 10689 MW; 571739D8E9B61B3C CRC64;
MASLKTPLLA ALVFLALILQ ATEAGPYGAN VEDSICCRDY FRHPLPLRML KFFYWTSDSC
RRPGVVFLTV KDREICADPR MPWVKKILQK LDQ
//
