ID A0A384D1C3_URSMA Unreviewed; 549 AA.
AC A0A384D1C3;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 03-AUG-2022, sequence version 2.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Adhesion G-protein coupled receptor G5 isoform X1 {ECO:0000313|RefSeq:XP_008700811.2, ECO:0000313|RefSeq:XP_040489293.1};
GN Name=ADGRG5 {ECO:0000313|RefSeq:XP_008700811.2,
GN ECO:0000313|RefSeq:XP_040489293.1, ECO:0000313|RefSeq:XP_040489294.1,
GN ECO:0000313|RefSeq:XP_040489295.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008700811.2};
RN [1] {ECO:0000313|RefSeq:XP_008700811.2, ECO:0000313|RefSeq:XP_040489293.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008700811.2,
RC ECO:0000313|RefSeq:XP_040489293.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_008700811.2; XM_008702589.2.
DR RefSeq; XP_040489293.1; XM_040633359.1.
DR RefSeq; XP_040489294.1; XM_040633360.1.
DR RefSeq; XP_040489295.1; XM_040633361.1.
DR KEGG; umr:103673758; -.
DR OrthoDB; 5477252at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR003910; GPR1/GPR3/GPR5.
DR InterPro; IPR000203; GPS.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF326; ADHESION G-PROTEIN COUPLED RECEPTOR G5; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01422; GPR56ORPHANR.
DR SMART; SM00303; GPS; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_008700811.2,
KW ECO:0000313|RefSeq:XP_040489293.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..549
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041072405"
FT TRANSMEM 269..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..328
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..364
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 376..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 431..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 477..496
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 502..524
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 269..528
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 39..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..66
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 549 AA; 61280 MW; D2D5B8FDB92EB44B CRC64;
MDCWGAFLLC LCFMTSQSET METSQDPLLW MEKLERMARS RNSTSAHPQG KARKGFRKEE
STEPDQKESS LALSLIRGLE RSLLNASFGG SNLTLQTPTI QSLVFKLGCS FPGLSLSSAS
VERDPQAWVS HAMQFPAQLT QDACRNSPRE LRLICTYFLT DYFFQNTNSS LLNNYVLGAQ
LGSGHVSNLK ESVNISFRHN QSLEGYTVTC VFWKEGASKH YWGVWSPEGC RTEKPSHSEV
LCRCNHLSYF AVLMQLSPAQ VPPELLKPLT YITLVGCSVS IVASLLTVLL HFQARKQGDS
LTRIHVNLHA SVLLLNVAFL LSPVLAVAPA SESACAALAA VLHFALLSCF TWMAIEGFNL
YLLLGHVYNI YVRRYLLKLC AVGWGVPALL VLSVLVAKNS VYGPYVIPLA DSQENGTGFQ
NTSMCWVRNP WVHSILVMGY SGLTCLFNLV VLVWALRVLH RLRARDKVPS TRACRDSVTV
LGLTVLLGTT WILAFFSFDV FLLPQLFLFT TFSSLYGFFL FLWFCSHRCR SEAEVEAEME
AFSSTQTTQ
//
