ID A0A384D3I4_URSMA Unreviewed; 431 AA.
AC A0A384D3I4;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Bone morphogenetic protein 2 {ECO:0000256|ARBA:ARBA00035684};
GN Name=BMP2 {ECO:0000313|RefSeq:XP_008701556.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008701556.1};
RN [1] {ECO:0000313|RefSeq:XP_008701556.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008701556.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR RefSeq; XP_008701556.1; XM_008703334.2.
DR AlphaFoldDB; A0A384D3I4; -.
DR GeneID; 103674423; -.
DR KEGG; umr:103674423; -.
DR CTD; 650; -.
DR OrthoDB; 2912454at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
DR CDD; cd19390; TGF_beta_BMP2; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR047953; BMP2_TGF_beta-like.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF143; BONE MORPHOGENETIC PROTEIN 2; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Chondrogenesis {ECO:0000256|ARBA:ARBA00023188};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Osteogenesis {ECO:0000256|ARBA:ARBA00022855};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 314..431
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 307..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..328
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 431 AA; 48759 MW; AC3A607AAE88256D CRC64;
MCLGLFRERR GVRPSGGFPR FPAQAVSASV TEKRSTMVAG TRCLLALLLP QVLLGGAAGL
IPELGRRKFA ASTGRSSSQP SEEVLSEFEL RLLSMFGLKR RPTPSRDAVV PPYMLDLYRR
HSGQPGAPAP DHRLERAASL ANTVRSFHHE ESLEELPEMS GKTTRRFFFN LTSIPTDEFI
TSAELQVFRE QMQETLENNS SFHHRINIYE ILKPEAANLK FPVTRLLDTR LVNQNASRWE
SFDVTPAVMR WTAQGLANHG FVVEVTHLEE NQGVSKRHVR ISRSLHQDEH SWSQIRPLLV
TFGHDGKGHP LHKREKRQAK HKQRKRLKSS CKRHPLYVDF SDVGWNDWIV APPGYHAFYC
HGECPFPLAD HLNSTNHAIV QTLVNSVNSK IPKACCVPTE LSAISMLYLD ENEKVVLKNY
QDMVVEGCGC R
//
