ID A0A384D556_URSMA Unreviewed; 530 AA.
AC A0A384D556;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 03-AUG-2022, sequence version 2.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Glycerate kinase {ECO:0000256|ARBA:ARBA00020720};
DE EC=2.7.1.31 {ECO:0000256|ARBA:ARBA00012101};
GN Name=GLYCTK {ECO:0000313|RefSeq:XP_008701919.2,
GN ECO:0000313|RefSeq:XP_008701920.2, ECO:0000313|RefSeq:XP_008701921.2};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008701919.2};
RN [1] {ECO:0000313|RefSeq:XP_008701919.2, ECO:0000313|RefSeq:XP_008701920.2}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008701919.2,
RC ECO:0000313|RefSeq:XP_008701920.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-glycerate + ATP = (2R)-3-phosphoglycerate + ADP + H(+);
CC Xref=Rhea:RHEA:23516, ChEBI:CHEBI:15378, ChEBI:CHEBI:16659,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58272, ChEBI:CHEBI:456216;
CC EC=2.7.1.31; Evidence={ECO:0000256|ARBA:ARBA00000694};
CC -!- SIMILARITY: Belongs to the glycerate kinase type-2 family.
CC {ECO:0000256|ARBA:ARBA00005393}.
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DR RefSeq; XP_008701919.2; XM_008703697.2.
DR RefSeq; XP_008701920.2; XM_008703698.2.
DR RefSeq; XP_008701921.2; XM_008703699.2.
DR OrthoDB; 5404098at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0008887; F:glycerate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.10180; Glycerate kinase, MOFRL-like N-terminal domain; 1.
DR Gene3D; 3.40.1480.10; MOFRL domain; 1.
DR InterPro; IPR037035; GK-like_C_sf.
DR InterPro; IPR038614; GK_N_sf.
DR InterPro; IPR007835; MOFRL.
DR InterPro; IPR025286; MOFRL_assoc_dom.
DR InterPro; IPR039760; MOFRL_protein.
DR PANTHER; PTHR12227; GLYCERATE KINASE; 1.
DR PANTHER; PTHR12227:SF0; GLYCERATE KINASE; 1.
DR Pfam; PF13660; DUF4147; 1.
DR Pfam; PF05161; MOFRL; 1.
DR SUPFAM; SSF82544; GckA/TtuD-like; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|RefSeq:XP_008701919.2,
KW ECO:0000313|RefSeq:XP_008701920.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Transferase {ECO:0000313|RefSeq:XP_008701919.2,
KW ECO:0000313|RefSeq:XP_008701920.2}.
FT DOMAIN 45..295
FT /note="MOFRL-associated"
FT /evidence="ECO:0000259|Pfam:PF13660"
FT DOMAIN 409..521
FT /note="MOFRL"
FT /evidence="ECO:0000259|Pfam:PF05161"
SQ SEQUENCE 530 AA; 55614 MW; 66D213F26EAF13C5 CRC64;
MVLRAVGMAA VLQCLPCMAR APLRPLFTGG PVVRLASGMA LAEQAQQLFQ STVGAVLPGP
MLHRALSLDP GSGLLKVRDR SFQLRQNLYL VGFGKAVLGM AAAAEELLGQ HLVQGVISVP
KGIRAAMEHA GKQEMLLKPH SRVQVFEGAE DNLPDRDALR AALAIRQLAE GLTADDLLLV
LISGGGSALL PAPIPPVTLE EKQTLTKLLA ARGANIQELN TIRKALSQLK GGGLAQAAYP
AQVVSLILSD VVGDPVEVIA SGPTVASVHN VQDCLHILNR YGLRAALPRS VKTVLARADS
DPHRPHTCGH VLNVIIGSNV LALAEAQRQA EALGYRAVVL SAAIQGDVKS VARFYGLLAQ
VAGAHLTPPG TGASLEEEER LQEVAAELQL PDLQLKEALE AVVGARGPVC LLAGGEPTVQ
LQGSGKGGRN QELALRVGAE LGRWPPGPVD VLFLSGGTDG QDGPTEAAGA WVMPELASQA
AAEGLDVASF LSRNDSHTFF RCFRSGAHLL RMGLTGTNVM DAHLLFLRPR
//
