ID A0A384D939_URSMA Unreviewed; 664 AA.
AC A0A384D939;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 03-AUG-2022, sequence version 2.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Myotubularin-related protein 9 {ECO:0000313|RefSeq:XP_008703300.2};
GN Name=MTMR9 {ECO:0000313|RefSeq:XP_008703300.2};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008703300.2};
RN [1] {ECO:0000313|RefSeq:XP_008703300.2}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008703300.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_008703300.2; XM_008705078.2.
DR AlphaFoldDB; A0A384D939; -.
DR STRING; 29073.ENSUMAP00000030146; -.
DR KEGG; umr:103675940; -.
DR OrthoDB; 5474662at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0030234; F:enzyme regulator activity; IEA:Ensembl.
DR GO; GO:0019903; F:protein phosphatase binding; IEA:Ensembl.
DR GO; GO:0010507; P:negative regulation of autophagy; IEA:Ensembl.
DR GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
DR GO; GO:0060304; P:regulation of phosphatidylinositol dephosphorylation; IEA:Ensembl.
DR CDD; cd13211; PH-GRAM_MTMR9; 1.
DR CDD; cd14536; PTP-MTMR9; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF56; MYOTUBULARIN-RELATED PROTEIN 9; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR Pfam; PF21098; PH-GRAM_MTMR6-like; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680}.
FT DOMAIN 238..613
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 63..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 623..657
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 71..91
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 664 AA; 74887 MW; 488C6CC1C99776AD CRC64;
MKPVQPRPGP QVVVAAAGPA AERSLHPRPG PGRTGSARET PGPGPAPALV FPRPVTVTAG
LAAPTGAWGG ARPPRPVPAP PACPEPGHSP PQPCGGVTAS ALPDSAVPWL RPRETMEFAE
LIKTPRVDNV VLHRPFYPAV EGTLCLTGHH LILSSRQDNT EELWLLHSNI DAIDKRFVGP
LGTIIIKCKD FRIIQLDIPG MEECLNIASS IEALSTLDSI TLMYPFFYRP MFEVVEDGWH
SFLPEQEFEL YSSATSEWRL SYVNKEFAVC PSYPPIVIVP KPIDDEALRK VATFRHGGRF
PVLSYYHKKN GMVIMRSGQP LTGTNGRRCK EDEKLINATL RAGKRGYIID TRSLNVAQQA
RAKGGGFEQE AHYPQWRRLH KSIERYPILQ ESLIKLVEAC NDQTHNMDRW LGRLEASNWL
THIKEILTTA CLAAQCIDRE GASILIHGTE GTDSTLQVTS LAQIILEPRS RTIRGFEALI
EREWLQAGHP FQQRCAQSAY CNSKQKWESP VFLLFLDCVW QILRQFPCSF EFNENFLIML
FEHAYASQFG TFLGNNESER CKLKLQQKTM SLWSWVNRPS ELSKFTNPLF EANNLVIWPS
VAPQSLQLWE GIFLRWNRSS KYLDEAYEEM VNIIEYNKEL QAKVNVLRRQ LAELETEDGM
QESP
//