ID A0A384D9F9_URSMA Unreviewed; 631 AA.
AC A0A384D9F9;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 03-AUG-2022, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Kininogen-1 isoform X1 {ECO:0000313|RefSeq:XP_008703425.2};
GN Name=KNG1 {ECO:0000313|RefSeq:XP_008703425.2};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008703425.2};
RN [1] {ECO:0000313|RefSeq:XP_008703425.2}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008703425.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC {ECO:0000256|ARBA:ARBA00004239}.
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DR RefSeq; XP_008703425.2; XM_008705203.2.
DR AlphaFoldDB; A0A384D9F9; -.
DR STRING; 29073.ENSUMAP00000005422; -.
DR KEGG; umr:103676052; -.
DR OrthoDB; 5223498at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0042311; P:vasodilation; IEA:UniProtKB-KW.
DR CDD; cd00042; CY; 3.
DR Gene3D; 3.10.450.10; -; 3.
DR InterPro; IPR000010; Cystatin_dom.
DR InterPro; IPR046350; Cystatin_sf.
DR InterPro; IPR002395; Kininogen.
DR InterPro; IPR027358; Kininogen-type_cystatin_dom.
DR InterPro; IPR018073; Prot_inh_cystat_CS.
DR PANTHER; PTHR13814; FETUIN; 1.
DR PANTHER; PTHR13814:SF12; KININOGEN-1; 1.
DR Pfam; PF00031; Cystatin; 3.
DR PRINTS; PR00334; KININOGEN.
DR SMART; SM00043; CY; 3.
DR SUPFAM; SSF54403; Cystatin/monellin; 3.
DR PROSITE; PS00287; CYSTATIN; 1.
DR PROSITE; PS51647; CYSTATIN_KININOGEN; 3.
PE 4: Predicted;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Vasoactive {ECO:0000256|ARBA:ARBA00022858};
KW Vasodilator {ECO:0000256|ARBA:ARBA00022429}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..631
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5035476823"
FT DOMAIN 27..131
FT /note="Cystatin kininogen-type"
FT /evidence="ECO:0000259|PROSITE:PS51647"
FT DOMAIN 150..253
FT /note="Cystatin kininogen-type"
FT /evidence="ECO:0000259|PROSITE:PS51647"
FT DOMAIN 271..374
FT /note="Cystatin kininogen-type"
FT /evidence="ECO:0000259|PROSITE:PS51647"
FT REGION 387..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 593..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..454
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..513
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..534
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 631 AA; 70090 MW; 6DDFF15129C949B2 CRC64;
MRLLALLFLC SRLLPSVSQE SSQEIDCDDE DLFKAVDTAL KKYNSRNQIG NQFVLHRVTE
VIRTDDPDTF YSFKYQIREG NCSAESGKTW QECDYKDAAQ AATGECSATV GKRGNTKFSV
ATQTCQITPA EGPVVTAQYD CLGCVHPIST ASPDLEPVLR HAIEHFNNNT AHSHLFAVRE
VKRAHRQVVA GWNYEITYSI AQTNCSKENF LSLTPDCKSL LNGDIGECTD HAHMDLQLRI
ASFSQKCDLY PAEDFVQPSK ICSDCPKDIP VNSPELEVAL NHSIAKLNAE NNGTFYFKID
SVKSATVQMV AGKKFSIAFI ARETTCSKES NEELTESCQI NKYGHTLECK AEVFVIRWEE
KIYPTVNCQP LKKIILMKRP PGFSPFRSVP LEKTEEGTTV SSPHISMAPV PDEERDSGKE
QGPTRGHGWG HEKQIKHGFG HGHKPEHDQG RGYHGGRGLG HGYQKQHGLG HGHQREHGLA
HGHIREHGQG HGKYKNKRKD NGKPNDWKTE HLASSPEEST TSSAQTQEKT EGPTPLLSLA
QPGIAVTVPD FQDPDLIAAV MPNPSAPKES DDDWIPDIQI EPNSLSFNLI PDFPEKTSPK
CPGRPWKPVN GMNPAVEVKE FPDFDLTDAL Y
//
