ID A0A384D9U4_URSMA Unreviewed; 771 AA.
AC A0A384D9U4;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Probable cationic amino acid transporter {ECO:0000313|RefSeq:XP_008703564.1};
DE SubName: Full=Solute carrier family 7 member 14 {ECO:0000313|Ensembl:ENSUMAP00000014243};
GN Name=SLC7A14 {ECO:0000313|Ensembl:ENSUMAP00000014243,
GN ECO:0000313|RefSeq:XP_008703564.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008703564.1};
RN [1] {ECO:0000313|Ensembl:ENSUMAP00000014243}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008703564.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008703564.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_008703564.1; XM_008705342.2.
DR STRING; 29073.ENSUMAP00000014243; -.
DR Ensembl; ENSUMAT00000016900.1; ENSUMAP00000014243.1; ENSUMAG00000010488.1.
DR GeneID; 103676153; -.
DR KEGG; umr:103676153; -.
DR CTD; 57709; -.
DR OMA; WRSTWNT; -.
DR OrthoDB; 1421713at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR002293; AA/rel_permease1.
DR InterPro; IPR029485; CAT_C.
DR PANTHER; PTHR43243:SF17; CATIONIC AMINO ACID TRANSPORTER-RELATED; 1.
DR PANTHER; PTHR43243; INNER MEMBRANE TRANSPORTER YGJI-RELATED; 1.
DR Pfam; PF13520; AA_permease_2; 1.
DR Pfam; PF13906; AA_permease_C; 1.
PE 4: Predicted;
KW Amino-acid transport {ECO:0000256|ARBA:ARBA00022970};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022970}.
FT TRANSMEM 58..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 85..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 190..207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 254..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 331..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 416..433
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 564..585
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 597..615
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 627..648
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 627..675
FT /note="Cationic amino acid transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13906"
FT REGION 734..771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 771 AA; 83885 MW; F9220249CDD0001D CRC64;
MSGFLASLDP RRVQWGAAWY AMHSRILRTK PVESMLEGTG ATTAHGTKLA QVLTTMDLIS
LGVGSCVGTG MYVVSGLVAK EMAGPGVIVS FIIAAVASIL SGVCYAEFGV RVPKTTGSAY
TYSYVTVGEF VAFFIGWNLI LEYLIGTAAG ASALSSMFDS LANHTISRWM VDSVGTLNGL
GKGEESYPDL LALVIAIIVT IIVALGVKNS VGFNNVLNVL NLAVWVFIMI AGLFFINGKY
WAEGQFLPHG WSGVLQGAAT CFYAFIGFDI IATTGEEAKN PNTSIPYAIT ASLVICLTAY
VSVSMILTLM VPCNAIDTES PLMEMFVAHG FYAAKFVVAI GSVAGLTVSL LGSLFPMPRV
IYAMAGDGLL FRFLAHVSSY TETPVVACIV SGFLAALLSL LVSLRDLIEM MSIGTLLAYT
LVSVCVLLLR YQPESDIDGF VKFLSQEHTK KKEGILADCE KEVCSPVSEG EEFSGPATNT
CGAKNLPSLG DNEMLIGKSD KSNYSVNHPN YGTVDVTTGI EADESENIYL IKLKKLIGPR
YYTMRIRLGL PGKMDRPTAA TGHTVTTCVL LLFILMFVFC SFIIFGSDYI SEQSWWAILL
VVLMVLLISA LVFVILQQPE NPKKLPYMAP CLPFVPAFAM LVNIYLMLKL STITWIRFAV
WCFVEQLLIR LCGIWNSTLE ISAREEALHQ SMYQRYDVDD PFSAEEGFSY ATEGESQENW
GGPAEDKGFY YQQMSEAKAS TRTSSKAKGK SKHKQNSEAL IANDELDYSP E
//
