ID A0A384DAT6_URSMA Unreviewed; 1030 AA.
AC A0A384DAT6;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Semaphorin 6D {ECO:0000313|Ensembl:ENSUMAP00000013147};
DE SubName: Full=Semaphorin-6D isoform X3 {ECO:0000313|RefSeq:XP_008704148.1};
GN Name=SEMA6D {ECO:0000313|Ensembl:ENSUMAP00000013147,
GN ECO:0000313|RefSeq:XP_008704148.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008704148.1};
RN [1] {ECO:0000313|Ensembl:ENSUMAP00000013147}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008704148.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008704148.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR RefSeq; XP_008704148.1; XM_008705926.2.
DR Ensembl; ENSUMAT00000015606.1; ENSUMAP00000013147.1; ENSUMAG00000009435.1.
DR GeneID; 103676709; -.
DR CTD; 80031; -.
DR OrthoDB; 5399685at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd11269; Sema_6D; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF65; SEMAPHORIN-6D; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1030
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041168241"
FT TRANSMEM 620..643
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..512
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT REGION 701..732
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 744..782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 796..831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 868..943
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 978..1030
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 744..758
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 807..831
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 885..903
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 925..943
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 978..998
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1015..1030
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1030 AA; 115136 MW; 06C3C116A5F0DA3D CRC64;
MRFFLLCAYM LLLVISQLRA VSFPEDDEPL NTVDYHYSKQ YPVFRGRPSG NESQHRLDFQ
LMLKIRDTLY IAGRDQVYTV NLSEIPKTEV IPSKKLTWRS RQQDRENCAM KGKHKDECHN
FIKVFVPRND EMVFVCGTNA FNPMCRYYRL NTLEYDGEEI SGLARCPFDA RQTNVALFAD
GKLYSATVAD FLASDAVIYR SMGDGSALRT IKYDSKWIKE PHFLHAIEYG NYVYFFFREI
AVEHNNLGKA VYSRVARICK NDMGGSQRVL EKHWTSFLKA RLNCSVPGDS FFYFDVLQSI
TDIIQINGIP TVVGVFTTQL NSIPGSAVCA FSMDDIEKVF KGRFKEQKTP DSVWTAVPED
KVPKPRPGCC AKHGLAEAYK TSIDFPDETL SFIKSHPLMD SAVPPIADEP WFTKTRIRYR
LTAIAVDHTA GPHQNYTVIF VGSEAGVVLK VLAKTSPFSL NDSVLLEEIE AYNHAKCNAE
SEEDRKVISL QLDKDHHAVY VAFSSCIIRL PLSRCERYGS CKKSCVASRD PYCGWLSQGA
CGRVTPGMLL LTEDFFAFHN HSVGGYEQDT EYGNTAHLGD CHEILPTSTT PDYKIFGGPT
SGVRWEVQSG ESNQMVHMNV LITCVFAAFV LGAFIAGVAV YCYRDMFVRK NRKIHKDAES
AQSCTDSSGS FAKLNGLFDS PVKEYQQNID SPKLYSNLLT SRKELPPNGD TKSMVMDHRG
QPPELAALPT PESTPVLHQK TLQAMKSHSD KAHGHGASRK ETPQFFPSSP PPHSPLSHGH
IPSAIVLPNA THDYNTSFSN SNAHKAEKKL QNIDHPLTKS SSKRDHRRSV DSRNTLNDLL
KHLNDPNSNP KAIMGDIQMA HQTLMLDPVG PMSEVPPKVP NREASLYSPP STLPRNSPTK
RVDVPTTPGV PMTSLERQRG YHKNSSQRHS ISAMPKNLNS PNGVLLSRQP SMNRGGYMPT
PTGAKVDYIQ GTPVSVHLQP SLSRQSSYTS NGTLPRTGLK RTPSLKPDVP PKPSFVPQTT
SVRPLNKYTY
//
