ID A0A384DBH2_URSMA Unreviewed; 749 AA.
AC A0A384DBH2;
DT 07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT 07-NOV-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Rho GTPase activating protein 24 {ECO:0000313|Ensembl:ENSUMAP00000034621};
DE SubName: Full=Rho GTPase-activating protein 24 isoform X1 {ECO:0000313|RefSeq:XP_008704378.1, ECO:0000313|RefSeq:XP_040480884.1};
GN Name=ARHGAP24 {ECO:0000313|Ensembl:ENSUMAP00000034621,
GN ECO:0000313|RefSeq:XP_008704378.1, ECO:0000313|RefSeq:XP_040480884.1};
OS Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008704378.1};
RN [1] {ECO:0000313|Ensembl:ENSUMAP00000034621}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_008704378.1, ECO:0000313|RefSeq:XP_040480884.1}
RP IDENTIFICATION.
RC TISSUE=Whole blood {ECO:0000313|RefSeq:XP_008704378.1,
RC ECO:0000313|RefSeq:XP_040480884.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_008704378.1; XM_008706156.2.
DR RefSeq; XP_040480884.1; XM_040624950.1.
DR STRING; 29073.ENSUMAP00000034621; -.
DR Ensembl; ENSUMAT00000040959.1; ENSUMAP00000034621.1; ENSUMAG00000024930.1.
DR GeneID; 103676943; -.
DR KEGG; umr:103676943; -.
DR CTD; 83478; -.
DR OMA; ELLYYYK; -.
DR OrthoDB; 48967at2759; -.
DR Proteomes; UP000261680; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13379; PH_RhoGap24; 1.
DR CDD; cd04390; RhoGAP_ARHGAP22_24_25; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15228:SF19; RHO GTPASE-ACTIVATING PROTEIN 24; 1.
DR PANTHER; PTHR15228; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000261680}.
FT DOMAIN 19..125
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 135..329
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 330..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 583..639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 653..729
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 338..410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..477
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 602..618
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..639
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 749 AA; 84306 MW; 952C267A97790BEF CRC64;
MEENNDSTEN PQQGQGRNNA MKCGWLRKQG GFVKTWHTRW FVLKGDQLYY FKDEDETKPL
GTIFLPGNKV LEHPCNEESP GKFLFEVVPG GDRDRMTANH ESYLLMASTQ NDMEDWVKSI
RRVIWGPFGG GIFGQKLEDT VRYEKRYGNR LAPMLVEQCV DFIRQRGLKE EGLFRLPGQA
NLVKELQDAF DCGEKPSFDS NTDVHTVASL LKLYLRELPE PVIPYAKYED FLSCAKLLSK
EEEAGVKELA KQVKSLPVVN YNLLKYICRF LDEVQSYSGV NKMSVQNLAT VFGPNILRPK
VEDPLTIMEG TVVVQQLMSV MIGKHDRLFP KDGELQSKPQ EGVSNNNNEI PKKATMGQLQ
NKENNNTKDS PGRQCSWDKP ESPQRSGMDN GSPTALPGSK TNSPRNSVHK LDVSRSPPLM
VKKNPAFNKG SGIVTNGSFS SSNVEGLEKT QTTPNGSLQA RRTSSLKGSG TKMGTHSVQN
GTVRMGILNP DTLGNPMNGR NMSWLPNGYV TLRDNKQKEQ AGESGQHNRL STYDNVHQQF
SMMNLDDKQS IDSATWSTSS CEISLPENSN SCRSSTTTCP EQDFYGANFE DPVLDGPPQD
DLSHPGDYEN KSDRRSVGGR SSRATSSSDN SETFVGNTTS SHSALHSLVS SLKQEMTKQK
IEYESRIKSL EQRNLTLETE MMSLHDELDQ ERKKFTMIEI KMRNAERAKE DAEKRNDMLQ
KEMEQFFSTF GELTVEPRRT ERGNTIWIQ
//
